ISSN:0163-5581    

DOI:10.1080/01635588209513753

出版商:Taylor&Francis Group    

年代:1982

数据来源: Taylor

摘要:

AbstractThe influence of various local Estonian milk products on the nitrite concentration and the nitrosation process in vitro was studied. Milk products were found to have a distinct nitrite level decreasing effect, and this effect was dependent upon fat concentration. All milk products with fat levels of 0.6%‐3.2% blocked the formation of nitrosodimethylamine (NDMA). Products with a 10%‐20% fat content had no effect on NDMA formation, or even increased the nitrosation. The inhibitory effect of milk on the nitrosation process is discussed. The authors recommend the inclusion of low‐fat milk products in everyday diet, especially in areas of high nitrite‐and nitrate‐rich food consumption.

ISSN:0163-5581    

DOI:10.1080/01635588209513754

出版商:Taylor&Francis Group    

年代:1982

数据来源: Taylor

摘要:

AbstractThe effects of protein intake on the levels of total and holo‐ornithine decarboxylase (ODC) in colon and liver have been examined in male Sprague‐Dawley rats fed varying amounts of casein in a defined purified diet. Pair‐feeding was used to eliminate effects of food intake per se. In the colon, both total and holo‐ODC activity increased in animals fed a low‐protein diet (1% casein). In the liver, on the other hand, both total and holo‐ODC activity decreased with protein deprivation. The observed changes in both colon and liver appeared to be maximal within several days after institution of the dietary regimen. Refeeding with a high‐protein diet (20% casein) led to a dramatic rise in ODC activity in the liver in animals previously fed a low‐protein diet. These results may be important in sorting out the effects of diet on the tumorigenic process.

ISSN:0163-5581    

DOI:10.1080/01635588209513755

出版商:Taylor&Francis Group    

年代:1982

数据来源: Taylor

摘要:

AbstractMammary cancer was induced in 50‐day‐old Sprague‐Dawley rats with either 25 mg/kg body weight of N‐methyl‐N‐nitrosourea (MNU) or 10 mg/rat of dimethyl‐benz(a)anthracene (DMBA). The retinoid N‐(4‐hydroxyphenyl)‐all‐trans‐retinamide (RAHA) was begun in the diet (2.0 mmol/kg diet) of MNU‐induced rats at 21, 48, or 52 days of age, and at 21 or 60 days of age for DMBA‐induced rats. RAHA was terminated 12–17 weeks postinduction, and the animals were sacrificed at 28 weeks postinduction. Significant inhibition of tumor incidence or multiplicity was found in only one group (rats fed RAHA beginning at 48 days of age). This was not considered sufficient evidence to conclude that short‐term administration of RAHA altered mammary tumor development.

ISSN:0163-5581    

DOI:10.1080/01635588209513756

出版商:Taylor&Francis Group    

年代:1982

数据来源: Taylor

摘要:

AbstractThe possible inhibitory effect of vitamin C (sodium ascorbate) on metastases from two transplantable murine tumors was studied. The first murine tumor, colon carcinoma CA‐51, was subcutaneously transplanted into male Balb/c mice. Immediately after tumor implantation, the mice were given either 1.0% sodium ascorbate or tap water. Subcutaneous tumors were surgically removed from one half of the animals in each group when the tumors reached a size of 1.5 cm. Results indicated no differences in survival, in the number of mice with metastases, or in the size of metastases between treated and untreated groups.The second murine tumor, lymphosarcoma 6C3HED, was subcutaneously implanted into C3H male and female mice. Sodium ascorbate (1.0% or3.0%) wasad‐ministered as above, but surgery was not performed. Again, no significant differences in the number of mice with metastases were observed between treated and untreated groups, with the exception of brain and regional lymph node metastases (enhanced, in males, by ascorbate).

ISSN:0163-5581    

DOI:10.1080/01635588209513757

出版商:Taylor&Francis Group    

年代:1982

数据来源: Taylor

ISSN:0163-5581    

DOI:10.1080/01635588209513758

出版商:Taylor&Francis Group    

年代:1982

数据来源: Taylor

摘要:

AbstractNutritional status indicators were assessed chemically in blood and urine taken from 625 Transkeians drawn from three age‐groups in each of two regions: one with a moderate risk for esophageal cancer and one with a very high risk. Aggregate mean values for protein, albumin, vitamin A, and phosphorus were generally acceptable, but many subjects had inadequate (though not necessarily deficient) values for nicotinic acid (74% of subjects), magnesium (60%), vitamin C (55%), carotene (53%), riboflavin (41%), calcium (35%), and zinc (27%). Groups at highest risk for esophageal cancer had markedly lower serum magnesium and carotene concentrations and mildly depressed hemoglobin and hematocrit values, but such findings are not necessarily associated with esophageal cancer etiology. Possible intestinal ma/absorption in the populations at highest risk may be associated with the unusually high fiber and phytate intake of the high‐risk populations as well as with exposure to necrotizing mycotoxins. Thus, while protein and energy nutriture seem generally adequate, both the high‐and moderate‐risk populations had high incidences of multiple micronutrient malnutrition.

ISSN:0163-5581    

DOI:10.1080/01635588209513759

出版商:Taylor&Francis Group    

年代:1982

数据来源: Taylor

摘要:

AbstractBased on epidemiological and biological data, Laminaria, a brown kelp seaweed, is proposed as an important factor contributing to the relatively low breast cancer rates reported in Japan. Several possible mechanisms for the influence of Laminaria on breast cancer are proposed: Laminaria is a source of nondigestible fiber, thereby increasing fecal bulk and decreasing bowel transit time; it changes the post hepatic metabolism of sterols; it contains an antibiotic substance that may influence fecal ecology; it contains 1–3 beta glucan, which alters enzymatic activity of fecal flora; and it stimulates the host‐mediated immune response. It is suggested that Laminaria may play a role in preventing either the initiation of breast cancer or its promotion by endogenous physiological factors.

ISSN:0163-5581    

DOI:10.1080/01635588209513760

出版商:Taylor&Francis Group    

年代:1982

数据来源: Taylor

ISSN:0163-5581    

DOI:10.1080/01635588209513761

出版商:Taylor&Francis Group    

年代:1982

数据来源: Taylor

ISSN:0163-5581    

DOI:10.1080/01635588209513762

出版商:Taylor&Francis Group    

年代:1982

数据来源: Taylor