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1. |
Tissue concentrations and proliferative effects of massive doses of ascorbic acid in the mouse |
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Nutrition and Cancer,
Volume 4,
Issue 4,
1982,
Page 241-246
DeschnerEleanorE.,
AlcockNancy,
OkamuraTakashi,
DeCosseJeromeJ.,
SherlockPaul,
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摘要:
AbstractThe effect of ascorbic acid supplementation on CFt mice fed ascorbic acid for approximately six months at dose levels of 1%, 5%, and 10% of diet was investigated by analysis of tissue ascorbic acid concentration in the liver, kidney, stomach, small intestine, and large bowel. The effect on epithelial cell proliferation was also examined in the small and large bowel but only at the 5% level. In the control animals, ascorbic add concentration was lowest in the liver (0.406±0.07 mg/g) and highest in the small bowel (0.754±0.16 mg/g). Dietary intake of 5 % and 10% ascorbic acid significantly elevated levels in the liver (0.741±0.13; p<0.05), and all doses of ascorbic acid significantly raised tissue concentrations in the kidney and colon. No difference was observed in the percentage of DNA‐synthesizing cells in the jejunum of controls or animals fed 5% ascorbic acid at 1 or 24 hours after3HTdR injection. However, at 1 hour a significantly decreased level of proliferation was observed in the distal colon of ascorbic‐acid‐treated mice compared with controls (labeling index [L.I.] = 7.3±0.28 vs. 10.1±1.15; p<0.05), and an even greater suppression of DNA synthesis was achieved by 24 hours (L.I. =11.4±1.06 vs. 18.6±1.61; p<0.01). None of the doses of ascorbic acid employed was toxic to the experimental mice.
ISSN:0163-5581
DOI:10.1080/01635588209513764
出版商:Taylor&Francis Group
年代:1982
数据来源: Taylor
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2. |
Nutrient intake and hormonal status of premenopausal vegetarian seventh‐day adventists and premenopausal nonvegetarians |
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Nutrition and Cancer,
Volume 4,
Issue 4,
1982,
Page 247-259
ShultzTerryD.,
LeklemJamesE.,
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摘要:
AbstractThe relationship between dietary nutrients and plasma estrone, estradiol‐17β, estriol, dehydroepiandrosterone sulfate, and prolactin levels was investigated in 14 premenopausal Seventh‐day Adventist vegetarian (SV) women and 9 premenopausal non‐Seventh‐day Adventist nonvegetarian (NV) women. The SV subjects consumed less fat, especially saturated fat, and used significantly less fried foods than the NV subjects. Plasma levels of estrone and estradiol‐17βin the SV subjects were significantly lower than in the NV subjects. SV estradiol‐17βand estriol levels were positively correlated with linoleic acid and protein intake, while NV prolactin levels were significantly correlated with intakes of oleic and linoleic acids and total fat. The data suggest that specific dietary nutrients were related to the hormonal milieu of these SV and NV subjects.
ISSN:0163-5581
DOI:10.1080/01635588209513765
出版商:Taylor&Francis Group
年代:1982
数据来源: Taylor
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3. |
Carcinogenicity examination of betel quid. II. Effect of vitamin a deficiency on rats fed semipurified diet containing betel nut and calcium hydroxide |
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Nutrition and Cancer,
Volume 4,
Issue 4,
1982,
Page 260-266
TanakaTakuji,
MoriHideki,
FujiiMasahiko,
TakahashiMasayoshi,
HironoIwao,
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摘要:
AbstractThe effect of vitamin A deficiency on the carcinogenicity of betel quid was studied, using long‐term feeding of vitamin‐A‐deficient and‐sufficient diets with and without betel nut and calcium hydroxide in ACI rats. A high incidence of focal epithelial hyperplasia was observed in the upper digestive tract (tongue, buccal oral mucosa, esophagus, and forestomach) of rats in the group given the vitamin‐A‐deficient diet mixed with betel nut and calcium hydroxide. The vitamin‐A‐deficient group also showed a high incidence of squamous papilloma in the tongue, buccal mucosa, and forestomach. The incidence of hyperplastic lesions of the tongue and buccal oral mucosa was significantly higher in this group than in the group receiving the vitamin‐A‐sufficient diet with betel nut and calcium hydroxide. These results suggest that the vitamin‐A‐deficient condition enhanced the growth of epithelial hyperplasia that was due to the administration of the betel quid ingredients. However, vitamin A did not protect against the development of altered liver cell foci, which were frequently seen with a small number of hepatocellular neoplasms in all groups given the diets containing betel nut and calcium hydroxide (both vitamin‐A‐deficient and‐sufficient groups).
ISSN:0163-5581
DOI:10.1080/01635588209513766
出版商:Taylor&Francis Group
年代:1982
数据来源: Taylor
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4. |
Dietary protein and cecal microbial metabolism in the rat |
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Nutrition and Cancer,
Volume 4,
Issue 4,
1982,
Page 267-272
WiseAlan,
MallettAnthonyK.,
RowlandIanR.,
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摘要:
AbstractAdult rats were fed diets containing 0, 25, 50, 100, 200, or 400 g lactalbumin/kg diet for 10 days, and the activities of six cecal microbial enzymes were determined. Total activity per cecum of azoreductase,β‐glucosidase, and urease increased significantly with increasing dietary protein, whereas the activities ofβ‐glucuronidase and nitroreductase were not significantly affected. Nitrate reductase activity decreased significantly. Total numbers of cecal bacteria were not significantly altered by the treatment.
ISSN:0163-5581
DOI:10.1080/01635588209513767
出版商:Taylor&Francis Group
年代:1982
数据来源: Taylor
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5. |
Diet and cancer: Food additives, coffee, and alcohol |
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Nutrition and Cancer,
Volume 4,
Issue 4,
1982,
Page 273-279
SandlerRobertS.,
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ISSN:0163-5581
DOI:10.1080/01635588209513768
出版商:Taylor&Francis Group
年代:1982
数据来源: Taylor
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6. |
Is increased cholesterol excretion the link between low serum cholesterol and colon cancer? |
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Nutrition and Cancer,
Volume 4,
Issue 4,
1982,
Page 280-284
LowenfelsAlbertB.,
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摘要:
AbstractThe data from several different patient groups consuming high‐fat, high‐cholesterol diets suggest that decreased serum cholesterol may be linked with increased cholesterol excretion. Since cholesterol or its degradation products have been implicated in the pathogenesis of colon cancer, an inverse relationship between serum and biliary cholesterol levels could explain the statistical relationship between low serum cholesterol and colon cancer observed in recent prospective studies.
ISSN:0163-5581
DOI:10.1080/01635588209513769
出版商:Taylor&Francis Group
年代:1982
数据来源: Taylor
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7. |
Cancerostatic effect of vegetarian diets |
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Nutrition and Cancer,
Volume 4,
Issue 4,
1982,
Page 285-291
SiguelEduardoN.,
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摘要:
AbstractA cancerostatic effect of vegetarian diets is proposed on the basis of a selective alteration of the metabolic pathways of fatty acids in neoplastic cells. Most vegetables lack the enzyme 6‐desaturase (6D), which converts linoleic to arachidonic acid. Human cells have 6D, and therefore humans do not need to eat the higher polyunsaturated fatty acids found in animal tissues. Many neoplastic cells have lost the activity of 6D. A vegetarian diet would deprive neoplastic cells of higher‐chain fatty acids and inhibit the activity of 6D. Without higher‐carbon fatty acids, neoplastic cell membranes would have altered fluidity and thus altered transport properties, receptor activity, sensitivity to external molecules, ability to reproduce, resistance to external agents (drugs, radiation, immune defenses, temperature), and overall survival. These alterations would make the cells easier prey for the self‐defense of the body or for attack with therapeutic agents. Thus, a vegetarian diet would alter the tumor cell lipid membranes and decrease neoplastic cell survival.
ISSN:0163-5581
DOI:10.1080/01635588209513770
出版商:Taylor&Francis Group
年代:1982
数据来源: Taylor
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8. |
Editorial board |
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Nutrition and Cancer,
Volume 4,
Issue 4,
1982,
Page -
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ISSN:0163-5581
DOI:10.1080/01635588209513763
出版商:Taylor&Francis Group
年代:1982
数据来源: Taylor
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