ISSN:0163-5581    

DOI:10.1080/01635588509513827

出版商:Taylor&Francis Group    

年代:1985

数据来源: Taylor

摘要:

AbstractThe relationships between areal differences in mortality from six digestive‐tract cancers and consumption of selected foods in 46 of the 47 Japanese prefectures (Okinawa being excluded) were analyzed.Statistical analyses disclosed that the groups of foods positively associated with cancer death were as follows: for esophageal cancer, pork, oil, popular‐grade sake, and green tea; for stomach cancer, fresh fish, salted or dried fish, salt, and special‐grade sake; for colon cancer, bread, milk, butter, margarine, ketchup, beer, and salted or dried fish; for rectal cancer, fresh fish, salted or dried fish, salt, and popular‐grade sake; for cancer of the biliary passages, pork, popular‐grade sake, and green tea; and for pancreatic cancer, oil, mayonnaise, fresh fish, and salted or dried fish.These results are based on statistical analyses. Further epidemiológica! analyses are required to find a biological causal relationship.(Nutr Cancer 6, 220–228, 1985)

ISSN:0163-5581    

DOI:10.1080/01635588509513828

出版商:Taylor&Francis Group    

年代:1985

数据来源: Taylor

摘要:

AbstractIntestinal cancer was induced in inbred male D/A rats by 1,2‐dimethylhydrazine, and the interrelationships between a high‐fat (33.5% w/w) diet, beer and alcohol (4.8% v/v) ingestion, and tumor location and incidence were examined. The number of tumors per animal was significantly greater in both the small and large intestines of rats on the high‐fat diet, as opposed to the standard died. The 6‐fold increase in incidence of colorectal cancer occurred almost exclusively in the distal half of the large bowel; i.e., there was a highly significant (p<0.005) shift, similar to that seen in man in countries adopting high‐fat Western‐type diets. Neither alcohol nor beer ingestion affected the incidence of intestinal cancers, but beer was associated with a more distal distribution of small‐intestinal cancers in animals on the high‐fat diet. However, this was not considered sufficient evidence for any material effect of beer on experimental intestinal carcinogenesis.(Nutr Cancer 6, 229–235, 1985)

ISSN:0163-5581    

DOI:10.1080/01635588509513829

出版商:Taylor&Francis Group    

年代:1985

数据来源: Taylor

ISSN:0163-5581    

DOI:10.1080/01635588509513830

出版商:Taylor&Francis Group    

年代:1985

数据来源: Taylor

摘要:

AbstractEvidence that dietary fat has an influence on carcinogenesis comes from both epidemiological data and experiments with animals. The experimental studies have indicated that dietary fat acts primarily as a promoter of carcinogenesis and that the effect depends on the type as well as the amount of fat in the diet. Vegetable oils containing polyunsaturated fatty acids of the linoleic acid family (n‐6) have been shown to enhance mammary tumorigenesis, but a fish oil containing polyunsaturated fatty acids of the linolenic acid family (n‐3) had an inhibitory effect at higher levels of intake. These and other findings suggest that the effect may be related to prostaglandins or other biologically active products of polyunsaturated fatty acids. Epidemiological data show a positive correlation between dietary fat and mortality from cancer at various sites, and this is supported by results of animal experiments in the case of colon cancer and pancreatic cancer as well as breast cancer. In the epidemiological data, cancer mortality shows strong positive correlations with total dietary fat and with animal fat, but not with fat derived from plants. Fats and oils used as spreads, cooking fats, and salad oils are the main source of fat in the American diet. Other major sources are meats and dairy products. Fat intake could probably be reduced substantially without serious deleterious effects, and this might help to decrease the risk of developing certain types of cancer.(Nutr Cancer 6, 254–259, 1985)

ISSN:0163-5581    

DOI:10.1080/01635588509513831

出版商:Taylor&Francis Group    

年代:1985

数据来源: Taylor

摘要:

AbstractTurnover of [14C]thiamin was studied in mice with Ehrlich ascites carcinoma fed a thiamin‐deficient diet and injected with 5 or 2μg/mouse of the labeled vitamin. The process of conversion of [14C]thiamin to thiamin pyrophosphate (TPP) was monitored by measuring the activities of transketolase, pyruvate dehydrogenase, and oxoglutarate dehydrogenase. The amount of coenzyme‐unsaturated apotransketolase was assessed by measuring the TPP effect—determining transketolase activity with and without the addition of TPP in vitro.Tumor growth was accompanied by thiamin deficiency, manifested in an increase in [14C]thiamin incorporation into the host tissues and the absence of saturation of the tissues with the labeled vitamin over 13 days. Increased values for the turnover coefficients, reduction of thiamin‐dependent enzyme activities, elevation of the TPP effect, and a decrease in urinary excretion of the radioactive products also provided evidence for a disturbance in thiamin metabolism. The severity of the disturbance in thiamin metabolism during malignant tumor growth was directly related to the dose of the exogenous vitamin.(Nutr Cancer 6, 260–273, 1985)

ISSN:0163-5581    

DOI:10.1080/01635588509513832

出版商:Taylor&Francis Group    

年代:1985

数据来源: Taylor

ISSN:0163-5581    

DOI:10.1080/01635588509513833

出版商:Taylor&Francis Group    

年代:1985

数据来源: Taylor

ISSN:0163-5581    

DOI:10.1080/01635588509513826

出版商:Taylor&Francis Group    

年代:1985

数据来源: Taylor