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1. |
Editorial |
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Journal of Dermatological Treatment,
Volume 3,
Issue 4,
1992,
Page 169-169
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ISSN:0954-6634
DOI:10.3109/09546639209088716
出版商:Taylor&Francis
年代:1992
数据来源: Taylor
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2. |
Selection of patients for psoriasis clinical trials: a survey of the recent dermatological literature |
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Journal of Dermatological Treatment,
Volume 3,
Issue 4,
1992,
Page 171-176
PetersenLJ,
KristensenJK,
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摘要:
Reports of 62 psoriasis clinical trials listed in theCumulated Index Medicosfor the years 1988 and 1989 and published only in leading dermatological journals were evaluated for different elements of research methodology concerned with the recruitment of subjects. The evaluation included items such as eligibility criteria, the sampling process, ethical considerations and sample size calculation. Major weaknesses in the description of all aspects of the recruitment procedure were demonstrated. For example, a quantitative disease activity criterion at entry was mentioned in 15% of the studies, consecutive patients were included in 5% of the trials, sufficient information on ethical approval was given in 16% of the studies, and a pre-study sample size calculation was not mentioned in any of the trials.
ISSN:0954-6634
DOI:10.3109/09546639209088717
出版商:Taylor&Francis
年代:1992
数据来源: Taylor
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3. |
1α, 25-Dihydroxyvitamin D3(calcitriol) ointment in psoriasis |
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Journal of Dermatological Treatment,
Volume 3,
Issue 4,
1992,
Page 177-180
LangnerA,
VerjansH,
StapórV,
MolM,
FraczykowskaM,
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摘要:
The therapeutic efficacy and local and systemic safety of 3μg/g calcitriol ointment twice daily was assessed in a randomized, double-blind, vehicle-controlled, left-right study for 6 weeks treating 29 patients with severe chronic psoriatic plaques. The calcitriol treatment appeared to be very effective in improving erythema, induration, scaling and global severity of psoriatic plaques. The difference in clinical efficacy between calcitriol and vehicle ointment was highly significant as early as 1 week after the start of treatment. After 6 weeks, clearance of psoriatic lesions was found in 48% of calcitriol-treated sides and in 7% of vehicle-treated sides. Skin biopsies of calcitriol-treated sides revealed a reduction in epidermal hyperplasia, normalization of the keratinization process and decreased inflammation of the psoriatic skin. Calcitriol ointment did not cause cutaneous or systemic adverse reactions and did not induce disturbances of calcium and phosphorus horneo-stasis. Twice daily 3μg/g calcitriol ointment appears to be a safe and effective topical treatment for severe chronic psoriatic plaques.
ISSN:0954-6634
DOI:10.3109/09546639209088718
出版商:Taylor&Francis
年代:1992
数据来源: Taylor
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4. |
One-week treatment of tinea corporis and tinea cruris with terbinafine (Lamisil) 1% cream: a placebo-controlled study |
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Journal of Dermatological Treatment,
Volume 3,
Issue 4,
1992,
Page 181-184
EvansEGV,
ShahJM,
JoshipuraRC,
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摘要:
In a multicentre double-blind randomized parallel-group study, 31 patients who had mycologically proven tinea corporis or tinea cruris were treated topically with either terbinafine 1% cream or its vehicle, applied once daily for 1 week. The percentage of patients 'effectively treated' (combined mycological and clinical outcome) was 86% for terbinafine compared with 35% for placebo (P = 0.01, Fisher's Exact test, two tailed). No adverse events were reported during the study. Topical terbinafine 1% cream used once daily for 1 week is an effective and well-tolerated treatment for tinea corporis and tinea cruris.
ISSN:0954-6634
DOI:10.3109/09546639209088719
出版商:Taylor&Francis
年代:1992
数据来源: Taylor
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5. |
Clotrimazole—hydrocortisone, hydrocortisone and propylene glycol liniment in the treatment of seborrhoeic dermatitis of the scalp |
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Journal of Dermatological Treatment,
Volume 3,
Issue 4,
1992,
Page 185-188
AttilaP,
FörströmL,
HannukselaM,
KarvonenJ,
LehtonenL,
SaloOP,
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摘要:
Antifungal drugs have been reported to have efficacy in the treatment of seborrhoeic disorders. This phenomenon has been attributed to their effects againstPityrosporum ovalewhich is often present on the diseased skin. In the present double-blind study, 74 patients with seborrhoeic dermatitis of the scalp with typ-ical symptoms such as scaling, erythema and itching, were randomly allocated to 4-weeks' treatment with clotrimazole—hydrocortisone liniment, hydrocortisone or plain propylene glycol-containing liniment base. In addition to symptoms, the presence ofP. ovalewas determined before and after treatment. All main symptoms were markedly relieved in all treatment groups. The area affected was clearly reduced in most patients after weeks' treatment. There were no statistically significant differences between treatments in any parameter evaluated. In the final global assessment, the number of patients with a good response was highest in the clotrimazole-hydrocortisone treatment group: 84% vs. 77% in the hydrocortisone group. However, the number of cured patients was the same (76%) in the liniment base group. The area of affected skin decreased during the treatment in most patients: 60% of all patients had at the most 5% of the initial area left. Data from the culture of P.ovulewas evaluable from 54 patients. In only 14 cases, of which 5 were in the clotrimazole—hydrocortisone group, did the culture become negative after treatment. Eight patients discontinued the treatment prematurely; four due to lack of efficacy (three in the clotrimazole-hydrocortisone and one in the hydrocortisone group), one because of severe itching of the scalp (liniment base group) and three for other reasons. In conclusion, treatment of seborrhoeic dermatitis with plain hydrocortisone was as effective as the combination of clotrimazole and hydrocortisone. However, propylene glycol-containing liniment base was about as effective as the liniment with active drugs. The clinical results did not correlate well withP. ovulecultures.
ISSN:0954-6634
DOI:10.3109/09546639209088720
出版商:Taylor&Francis
年代:1992
数据来源: Taylor
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6. |
A randomized controlled trial of cultured keratinocyte allografts for chronic venous ulcers |
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Journal of Dermatological Treatment,
Volume 3,
Issue 4,
1992,
Page 189-191
DuhraP,
BlightA,
MountfordE,
CheshireI,
WithersA,
IlchyshynA,
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摘要:
The efficacy of cultured keratinocyte allografts on the healing rate and pain relief of 30 small and medium-sized chronic venous leg ulcers was assessed in a prospective, randomized, placebo-controlled study. Measurements of surface area, ulcer bed appearance and pain severity were made at fortnightly intervals for 6 weeks. There was significant healing of ulcers in both the allografted and control groups (P= 0.001), but there was no significant difference between the two groups (P>0.05). There was also no significant difference between the two treatments in the amount of pain relief obtained. Thus, a single application of cultured keratinocyte allografts to chronic venous ulcers offered no advantage for wound healing or pain relief as compared with placebo. The low efficacy and the expense of cultivating and storing allografts does not allow a single application of cultured allografts to be recommended at present as a routine treatment for venous leg ulcers.
ISSN:0954-6634
DOI:10.3109/09546639209088721
出版商:Taylor&Francis
年代:1992
数据来源: Taylor
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7. |
Treatment of verrucae vulgares in general practice—a randomized controlled trial on the effectiveness of liquid nitrogen and the Histofreezer |
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Journal of Dermatological Treatment,
Volume 3,
Issue 4,
1992,
Page 193-196
ErkensAMJL,
KuijpersRJAM,
KnottnerusJA,
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摘要:
In general practice, treating verrucae vulgares with liquid nitrogen has some practical drawbacks. Therefore, in a randomized controlled trial this therapy was compared with a new and easy-to-use form of cryotherapy, the Histofreezer. The warts were treated monthly with liquid nitrogen and twice a month with the Histofreezer. Included in the study were 93 patients with 191 verrucae of whom 17 (38 verrucae) did not comply fully during the study. With the liquid nitrogen treatment 66% of warts were cured, and 49% with the Histofreezer treatment (P = 0.08). All verrucae disappeared in 67% of the patients treated with Liquid nitrogen, and in 35% of those treated with the Histofreezer (P = 0.01). For dorsal, non-protuberant and small verrucae, and in patients younger than 21 years, there were almost no differences. In conclusion, the overall results of treatment with liquid nitrogen were better. However, in certain cases, e.g. in young children, the Histofreezer might be attractive. Further study in this direction is recommended.
ISSN:0954-6634
DOI:10.3109/09546639209088722
出版商:Taylor&Francis
年代:1992
数据来源: Taylor
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8. |
Topical sucralfate therapy for oral ulcers in Behçet's disease: a randomized double-blind study |
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Journal of Dermatological Treatment,
Volume 3,
Issue 4,
1992,
Page 197-199
KoçY,
AkpekG,
AkpolatT,
GüllüI,
KansuE,
KirazS,
BatmanF,
DuruS,
KansuT,
AkkayaS,
TelatarH,
ZileliT,
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摘要:
Sucralfate has been described as a cytoprotective agent and successfully used in the treatment of peptic ulcer, mucositis, and various types of mucosal ulcerations. In a double-blind randomized study, 35 patients with Behqet's disease having oral aphthous ulcerations were treated with topical sucralfate application or placebo. Oral aphthous ulcers were evaluated according to their number, duration, size and painfulness throughout a 12-week period. No statistically significant difference was found between the periods with and without sucralfate or placebo treatment. In conclusion, sucralfate was found to have no therapeutic or preventive effect on major or minor oral aphthous ulcers seen in patients with Behqet's disease.
ISSN:0954-6634
DOI:10.3109/09546639209088723
出版商:Taylor&Francis
年代:1992
数据来源: Taylor
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9. |
Treatment of psoriasis with 30% Dead Sea salt lotion |
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Journal of Dermatological Treatment,
Volume 3,
Issue 4,
1992,
Page 201-203
CheesbroughMJ,
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摘要:
Spa treatment at the Dead Sea has been shown to help psoriasis for many thousands of patients over the years. It is not known, however, what aspect of the treatment produces benefit. In this double-blind randomized study, Dead Sea salts (DSS) made up as a 30% lotion were used to treat patients with plaque psoriasis and compared with the base lotion as placebo. There were 12 patients in each group, and PASI scores were measured at 0, 4, 8 and 12 weeks. There were five withdrawals (one placebo and four DSS lotion). Analysis of PASI scores on those who completed the study showed slight improvement with the placebo and no change with the DSS lotion. Thus in this study 30% DSS lotion was not shown to have any beneficial effect.
ISSN:0954-6634
DOI:10.3109/09546639209088724
出版商:Taylor&Francis
年代:1992
数据来源: Taylor
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10. |
Rod and cone malfunction as a manifestation of isotretinoin therapy—a case report |
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Journal of Dermatological Treatment,
Volume 3,
Issue 4,
1992,
Page 205-207
WatsonNJ,
HutchinsonCH,
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摘要:
Isotretinoin (13cis-retinoic acid) has many reported adverse reactions, those affecting the eye are amongst the most common. We believe that the case reported here is the first reported of a patient with combined rod and cone photoreceptor damage. The potential mechanisms of isotre-tinoin-induced retinal dysfunction are discussed.
ISSN:0954-6634
DOI:10.3109/09546639209088725
出版商:Taylor&Francis
年代:1992
数据来源: Taylor
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