ISSN:0954-6634    

DOI:10.3109/09546639409080561

出版商:Taylor&Francis    

年代:1994

数据来源: Taylor

摘要:

A randomized double-blind parallel-group study compared the efficacy and tolerability of 0.05% and 0.1% isotretinoin cream with placebo cream base in 82 patients with mild to moderate facial acne vulgaris. The effects of treatment were assessed by acne grade and lesion count according to the method of Burke and Cunliffe. Significant reductions in acne grade after 4, 8 and 12 weeks were observed in both active treatment groups with the most pronounced improvement in whiteheads (P<0.01). The overall tolerability of the treatment was good to excellent in 79.2% of patients using 0.1% isotretinoin cream and in 73.1% using 0.05% cream.

ISSN:0954-6634    

DOI:10.3109/09546639409080562

出版商:Taylor&Francis    

年代:1994

数据来源: Taylor

摘要:

The purpose of this study was to evaluate the efficacy towards acne and the skin surface toxicity ofall-trans-retinoylβ-glucuronide (RBG), a naturally occurring retinoid possessing low cytotoxicity and teratogenicity in animal and cell culture studies. In a double-blind study, 15 acne patients treated with 1.2% RBG cream for 16 weeks showed median reductions of 56%, 25% and 67% in total, inflammatory, and noninflammatory lesions, respectively, whereas the placebo group (14 patients) showed median reductions of 31%, 4% and 62%, respectively. The median reduction in total lesions was highly significant in the RBG group(P= 0.002) but not in the placebo group(P= 0.06). In a second initially double-blind study, ten acne patients treated topically for 26 weeks with 0.16–0.32% RBG cream and five patients with 0.1%all-trans-retinoic acid (Retin-A) showed similar responses, i.e. median reductions in total facial lesions of 70% (P =0.001) and 75% (P= 0.01), respectively. Whereas all subjects treated topically with 0.1% Retin-A showed adverse skin reactions, none of those treated with concentrations of RBG up to 2.4% showed such effects. Thus, RBG seems to be a promising topical treatment for mild to moderate acne, particularly in subjects with highly sensitive skin.

ISSN:0954-6634    

DOI:10.3109/09546639409080563

出版商:Taylor&Francis    

年代:1994

数据来源: Taylor

摘要:

We investigated the effects of cyclosporin A (CyA) on the development of lupus dermatoses in autoimmune-prone MRL/Mp-lpr/lpr (MRL/lpr) mice. The MRL/lpr mouse is an animal model for the spontaneous development of skin lesions similar to those of human lupus erythematosus (LE). Virgin female MRL/lpr mice, at the age of 1 month were treated orally with CyA. CyA reduced the incidence and intensity of IgG immunofluorescence at the dermoepider-mal junction, the titre of serum anti-double-stranded DNA antibodies and lymphoproliferation. However, CyA did not improve the survival ratio, the incidence of skin lesions or lupus nephritis.

ISSN:0954-6634    

DOI:10.3109/09546639409080564

出版商:Taylor&Francis    

年代:1994

数据来源: Taylor

摘要:

In order to plan optimum drug regimens for the treatment of onychomycosis with terbinafine, it is necessary to have information concerning the pharmacokinetics of terbinafine in the nail plate. A group of 24 patients with mycology culture-positive onychomycosis took 125, 250 or 500 mg terbinafine once daily for 16 weeks in a double-blind parallel-group study. Distal nail clippings, proximal nail samples and blood samples were taken at frequent intervals during therapy and during a follow-up of up to 36 weeks. Of the 24 patients, 17 completed the study. There was an apparent dose response with regard to concentration of terbinafine and its main metabolite demethylterbinafine in the distal and proximal part of affected nails as well as in plasma. The length of time during which terbinafine could be detected after stopping treatment increased with increasing dosage. The results suggest that short-term therapy with the higher dosage regimens is likely to have a higher efficacy rate.

ISSN:0954-6634    

DOI:10.3109/09546639409080565

出版商:Taylor&Francis    

年代:1994

数据来源: Taylor

摘要:

Loratadine is a long-acting, orally effective, second-generation histamine H1-receptor antagonist with proven efficacy in the treatment of chronic idiopathic urticaria. It has an excellent safety profile, and is free of undesirable side-effects such as sedation and dry mouth which often accompany the use of the classic antihistamines. In the present 28-day study, loratadine was compared with astemizole, another second-generation H1antihistamine, for the treatment of chronic idiopathic urticaria in 110 patients (99 valid). Patients with moderate to severe pruritus and dermal lesions due to urticaria were randomly assigned to receive either loratadine (10 mg once daily) or astemizole (10 mg once daily). Both loratadine and astemizole were found to be effective in relieving the symptoms of urticaria for the duration of the study. Symptom scores were reduced by roughly 50% in both treatment groups. The efficacy of the two antihistamines was statistically comparable as determined by scoring of urticaria symptoms, therapeutic response, and global evaluation of anti-itching effect. Furthermore, the incidence of adverse events related to treatment was low and was statistically comparable between the two treatment groups. However, inasmuch as three astemizole patients experienced severe sedation, the safety profile favored loratadine.

ISSN:0954-6634    

DOI:10.3109/09546639409080566

出版商:Taylor&Francis    

年代:1994

数据来源: Taylor

摘要:

A 28-year-old female patient with pretibial myxoedema affecting both lower legs was treated with PUVA localized to the distal legs. The patient was given 8-methoxypsoralen in a dosage of 0.6 mg/kg 2 hours prior to UVA exposure (Waldmann PUVA 180 and 200 units). A total of 37 treatments, conducted over an 8-month period, gave a total exposure of 108.0 J/cm2and induced a clinical and histological remission. Loss of skin thickness was confirmed by a pulsed A-scan DM70 ultrasound of the affected sites. We discuss the use of PUVA as an effective treatment for a disfiguring condition which is otherwise resistant to therapy.xs

ISSN:0954-6634    

DOI:10.3109/09546639409080567

出版商:Taylor&Francis    

年代:1994

数据来源: Taylor

摘要:

Porphyria cutanea tarda (PCT) in women may be associated with distressing increased growth of vellus or androgen-influenced hair. Hirsutism may persist after clinical and biochemical remission of the PCT. For patients with persisting hirsutism, oestrogen therapy alone or in combination with cyproterone acetate is contraindicated as further disease activity may be provoked. We report the beneficial effect of spironolactone in a patient with PCT-associated hirsutism.

ISSN:0954-6634    

DOI:10.3109/09546639409080568

出版商:Taylor&Francis    

年代:1994

数据来源: Taylor

摘要:

Cyclosporin A (CyA) has recently been introduced successfully for the treatment of the pustular forms of psoriasis. We treated a 57-year-old female cook who had been suffering from Hallopeau's acrodermatitis continue for 12 years. She came under our care for a marked worsening of the clinical picture of the third finger of the right hand. We treated her with CyA at an initial dose of 4 mg/kg per day. After two months of therapy the finger had completely healed. No side-effects were noted, confirming the efficacy and safety of cyclosporin A in the treatment of acrodermatitis continue at low dose.

ISSN:0954-6634    

DOI:10.3109/09546639409080569

出版商:Taylor&Francis    

年代:1994

数据来源: Taylor

摘要:

We report a case of acute generalized exanthematous pustulosis induced by calcium dobesilate, a vasoactive drug with few secondary effects. An accidental re-exposure to the drug was shortly followed by a relapse. To our knowledge, this is theñrst report of acute generalized exanthematous pustulosis associated with calcium dobesilate.

ISSN:0954-6634    

DOI:10.3109/09546639409080570

出版商:Taylor&Francis    

年代:1994

数据来源: Taylor