ISSN:0954-6634    

DOI:10.3109/09546639609086873

出版商:Taylor&Francis    

年代:1996

数据来源: Taylor

摘要:

Topical vitamin D3is now widely accepted as a convenient and well-tolerated treatment modality for psoriasis. Among various biosynthetic vitamin D3analogues, 1,24-dihydroxycholecalciferol (tacalcitol), which is commercially available in Japan as an ointment containing 2μg/g, is unique because it does not induce any side-effects even when it is applied to facial psoriatic lesions. The clinical and histopathological similarities of seborrhoeic dermatitis to psoriasis led us to study the effectiveness of tacalcitol ointment for the treatment of the facial lesions of severe seborrhoeic dermatitis. We treated 15 patients with facial seborrhoeic dermatitis with topical applications of tacalcitol ointment twice daily. The lesions in 11 of the 15 patients markedly improved during the first 2 weeks of treatment. Only one patient stopped the treatment because of an enhancement of erythema and scaling during the first 2 weeks. In the final evaluation made after 6 weeks, two of the remaining three patients also showed marked improvement, and the other showed only slight improvement. Moderate improvement or better after 2, 4 and 6 weeks of treatment occurred in 73%, 83% and 89% of patients, respectively. There were no severe cutaneous or systemic adverse effects during the 6-week treatment period. None of the patients, who showed excellent responses, had relapsed at least 4 weeks after stopping treatment. We recommend this agent for severe facial lesions of seborrhoeic dermatitis.

ISSN:0954-6634    

DOI:10.3109/09546639609086874

出版商:Taylor&Francis    

年代:1996

数据来源: Taylor

摘要:

The aim of the study was to evaluate the efficacy and safety of cefadroxil once daily as compared to flucloxacillin twice daily in skin and soft tissue infections. The patients were given either Cefamox 1 g once daily or Heracillin 1.5 g (tablets twice daily or suspension three times daily) for 10 days in this randomized single-blind multicentre study. Of 661 patients aged 3–81 years, 651 qualified for the evaluation of adverse events, 642 for the intention-to-treat analysis of efficacy and 327 for the primary statistical evaluation of efficacy. The incidence of adverse events was similar for both drugs (cefadroxil 30%, flucloxacillin 36%). The clinical results of the treatments were satisfactory, with 97% of the patients being healed or improved in both groups. Treatment with cefadroxil 1 g once daily was equivalent to flucloxacillin twice or three times daily in the treatment of skin and soft tissue infections.

ISSN:0954-6634    

DOI:10.3109/09546639609086875

出版商:Taylor&Francis    

年代:1996

数据来源: Taylor

摘要:

Triaz 10% Gel (benzoyl peroxide special gel) is a topical, 10% benzoyl peroxide acne medication with a vehicle containing glycolic acid and zinc lactate. This 12-week study, using lesion counts and assessment of adverse effects, was designed to compare the efficacy and safety of benzoyl peroxide special gel with Benzamycin (5% benzoyl peroxide and 3% erythromycin) in the treatment of moderate to moderately severe, papular-pustular, facial acne vulgaris. A placebo base served as a control. Over 3 months of therapy with twice-daily application, benzoyl peroxide special gel was at least comparable to benzoyl peroxide-erythromycin in reducing inflamed lesions (papules + pustules), noninflamed lesions (open + closed comedones) and the total of these lesions. Moreover, benzoyl peroxide special gel was significantly less drying.

ISSN:0954-6634    

DOI:10.3109/09546639609086876

出版商:Taylor&Francis    

年代:1996

数据来源: Taylor

摘要:

Androgenetic alopecia (AGA) is a common yet poorly understood condition. In particular, the significance of inflammatory cells close to the infrainfundibulum of transitional hairs remains obscure. This study was conducted in 20 men who used a lotion containing the antimicrobials, piroctone olamine and triclosan, regularly for 18 months. At entry, mild pruritus and abnormal hair loss were reported by the volunteers. During treatment, pruritus resolved rapidly. Comparison of clinical photographs and trichograms taken at 3-month intervals suggested signs of hair regrowth with moderate increase in density of transitional hairs. Biopsies taken at 6-month intervals were processed for immunohistochemistry. There was a decrease in the density of activated T cells in the region of the follicular infrainfundibulum and isthmus over time. IgG deposits found within the epithelial sheaths at entry to the study were absent in the subsequent biopsies. The volume of the sebaceous glands, as assessed by computerized morphometry, was not modified by the treatment. It was concluded that inflammation associated with AGA transitional hairs may be driven by the presence of microorganisms harboured in the infrainfundibulum. They may modulate the severity of AGA and may potentially be controllable. This offers a new possibility of prevention and partial reversal of hair loss in AGA.

ISSN:0954-6634    

DOI:10.3109/09546639609086877

出版商:Taylor&Francis    

年代:1996

数据来源: Taylor

摘要:

A standardized 7.5% herbal extract preparation used to increase the density of hair growth was subjected to scientific investigation to evaulate its hair growth-promoting properties. A group of 24 healthy male subjects under the age of 55 years with stage III-IV androgenetic alopecia were enrolled in a randomized double-blind parallel-group vehicle-controlled study lasting 48 weeks. The hair inside a 1-cm tattooed triangle was harvested bimonthly. Measurements included total hair counts, non-vellus hair counts, average hair length and total hair weight. After 40 weeks of treatment, the mean total hair count increased by 77% in the active group compared to a 3% increase in the placebo group (P= 0.003). The number of non-vellus hairs in a 0.433 cm2area increased by 169% for the active group compared to 33% for the placebo group (P= 0.01). In the active group, 90% of the subjects showed an increase of more than 35% in non-vellus hair count compared with only 33% of the placebo group (P<0.05), and 60% of the active group had excellent results (100% increase in non-vellus hair count) compared with only 8% of the placebo group (P<0.05). It was seen that the standardized herbal preparation was significantly more effective than the placebo.

ISSN:0954-6634    

DOI:10.3109/09546639609086878

出版商:Taylor&Francis    

年代:1996

数据来源: Taylor

摘要:

Background and Objectives The flashlamp-pumped pulsed-dye laser is the treatment of choice for port-wine stains (PWS) but the tuberous component of PWS responds poorly to this treatment. This study evaluated the efficacy of vaporizing this component with a continuous carbon dioxide (CO2) laser.Materials and Methods The PWS tuberous components of 30 patients unresponsive to dye laser were treated with a continuous CO2laser. In 15 patients no anaesthesia was used.Results All the lesions disappeared. A texture change was detected in 37% of the patients and one patient developed hypertrophic scarring. Patient satisfaction was excellent in all cases. Pain was noted in only four of those patients who underwent treatment without anaesthesia.CONCLUSION CO2laser vaporization of the tuberous lesions of PWS is an excellent option complementary to treatment with the pulsed-dye laser.

ISSN:0954-6634    

DOI:10.3109/09546639609086879

出版商:Taylor&Francis    

年代:1996

数据来源: Taylor

摘要:

To our knowledge, no trial has so far been performed of 5-fluorouracil (5-FU) in the treatment of discoid lupus erythematosus. This open label study was carried out in 12 patients (5 males and 7 females, aged 20 to 47 years) to assess the short-and long-term efficacy and tolerability of a daily application of an ointment containing 5% 5-FU. The study was started in October 1993 when the disease was at a high degree of activity following summer sunlight exposure. After a 4-to 24-week treatment period, full remission was achieved in all patients. Healing resulted in cosmetically acceptable dyschromic and/or atrophic changes. During the summers 1994 and 1995, exacerbation of preexisting lesions and appearance of new lesions were observed in eight and two patients, respectively. However, remission of these lesions was obtained with a short course of therapy. The overall tolerability of the treatment was good or excellent in all patients. On the basis of the results of this preliminary study, topical 5-FU seems to be a promising therapeutic agent which might be introduced in the routine management of cutaneous lupus erythematosus.

ISSN:0954-6634    

DOI:10.3109/09546639609086880

出版商:Taylor&Francis    

年代:1996

数据来源: Taylor

摘要:

A clinical study was carried out on the effects of the application of a cream containing urea in 30 normal subjects and 40 patients with atopic dermatitis. In addition, in 20 treated atopic patients and 15 normal subjects, evaporimetry was carried out after 2 and 7 days. The subjective and objective clinical results and the evaporimetric data showed that twice daily applications of urea cream improved the dryness, the itching and the erythema of patients with atopic dermatitis. Furthermore, the patients considered the results to be correlated with the treatment and to be accompanied by a subjective feeling of greater skin plasticity. In the normal subjects there was also improvement in skin plasticity and a reduction in transepidermal water evaporation. In a laboratory study, the concentration of extractable epidermal lipids was also determined in eight treated atopic patients after 15 days of urea cream treatment. Polar fatty acids were much lower and the difference was due exclusively to reduced epidermal desquamation. Surprisingly, the ceramides appeared to be increased and there was also a 30% increase in the linoleic acid content, as compared with the scores before treatment. The changes in skin hydration, the better cohesion of the keratinocytes and the consequent decrease in desquamation facilitate the formation of a healthier epidermal barrier and a better epidermal lipid composition.

ISSN:0954-6634    

DOI:10.3109/09546639609086881

出版商:Taylor&Francis    

年代:1996

数据来源: Taylor

摘要:

A group of 46 patients, 4 to 74 years old, scheduled for laser treatment of port-wine stains were included in a multicentre double-blind study designed to assess the analgesic effect of EMLA cream. Patients were randomly allocated to receive EMLA (n= 23) or placebo cream (n= 23) applied a minimum of 1 h before treatment. Pain was assessed on a 10-cm visual analogue scale (VAS). Of the 46 patients, 41 were available for efficacy analysis. The difference in VAS scores was found to be statistically significant in favour of EMLA compared with placebo. The median VAS scores were 2.4 and 4.8 for EMLA and placebo patients, respectively. Pain scores according to age (adult/child), localization of angioma (head and neck/other), type of laser (argon, YAG, pulsed and continuous dye laser), and cream application time (>or 90 min) were lower with EMLA. Transient local skin reactions were observed with both formulations with equal frequency. It is concluded that EMLA reduces pain in laser treatment of port-wine stains after a minimum application time of 1 h.

ISSN:0954-6634    

DOI:10.3109/09546639609086882

出版商:Taylor&Francis    

年代:1996

数据来源: Taylor