ISSN:0954-6634    

DOI:10.3109/09546639009086711

出版商:Taylor&Francis    

年代:1990

数据来源: Taylor

摘要:

A single-blind randomized controlled trial was performed to compare the clinical efficacy of Condyline (0.5% podophyllotoxin) solution with Condyline (0.5% podophyllotoxin) cream and 20% podophyllin solution in the treatment of condylomata acuminata. Fifty-four patients were included in the study. Both Condyline treatments were applied by the patients themselves twice daily on three consecutive days per week. Podophyilin was applied once a week by the physician. The duration of therapy ranged from 1 to 6 weeks, depending on the efficacy of treatment. The number of condylomata as well as their location and size were noted. If the condylomata had not cleared after 6 weeks of therapy, treatment was considered a failure. The combined results for the two Condyline formulations, assessed after 3 weeks of therapy, showed a significantly more rapid healing rate for Condyline as compared to podophyllin. Furthermore, after 6 weeks of therapy Condyline solution had a significantly higher healing rate than podophyllin and Condyline cream. The incidence of adverse reactions was higher in the Condyline treated groups, especially with the cream formulation. Most of these were, however, mild and regressed within 2 to 7 days.

ISSN:0954-6634    

DOI:10.3109/09546639009086712

出版商:Taylor&Francis    

年代:1990

数据来源: Taylor

摘要:

Sixty women with acne resistant to conventional antibiotic therapy were investigated to determine the incidence of clinical markers of hyperandrogenism and were compared with 60 women who had responded adequately to equivalent therapy. The mean hirsuties scores for the therapy-resistant and therapy-responsive groups were similar (2.0 and 2.1 respectively). The incidence of significnt hirsuties (score>6) was low and not significantly different between the two groups (6.7% and 3.3% respectively). The two groups were also similar in respect of age at menarche, incidence of male and female pattern androgenetic alopecia, keratosis pilaris, acanthosis nigricans and hidradenitis suppurativa. The incidence of menstrual irregularity was lower in the therapy-resistant group but not significantly so. These results show that clinical features of hyperandrogenism and lack of response to conventional antibiotic therapy are not related. Thus clinical markers of hyperandrogenism cannot help the clinician in deciding which female patients will or will not respond to conventional antibiotic therapy.

ISSN:0954-6634    

DOI:10.3109/09546639009086713

出版商:Taylor&Francis    

年代:1990

数据来源: Taylor

摘要:

Twenty-three patients with 30 nails affected by dermato-phyte infection were treated with a topical application of 1% bifonazole (Bayer) with 40% urea. Direct examination for fungi and culture on Sabouraud's medium were both positive for dermatophytes in all cases before treatment. Clinical and mycological examinations were carried out weekly until normal nail growth occurred. At the end of week 1 after treatment most direct examinations (66%) for fungal mycelium gave negative results and all cultures were negative. By week 4 of treatment 30% of nails detached. Detachment did not occur in 2 cases. Reinfection was observed in only 3 cases (10%). The bifonazole/urea combination is a very effective treatment in onychomycosis and avoids the systemic toxicities of other drugs.

ISSN:0954-6634    

DOI:10.3109/09546639009086714

出版商:Taylor&Francis    

年代:1990

数据来源: Taylor

摘要:

Two children with bullous and non-bullous ichthyosiform erythroderma improved dramatically with tretinoin under occlusion and 15% urea in emollient. Treatment was well tolerated and there were no clinical or biochemical complications after 18 months of therapy. This combination appears to be effective and safe in the treatment of ichthyosiform erythroderma. However, in order to be successful, treatment needs to be incorporated into the family life-style and become part of the patient's daily routine. This treatment regimen should permit the deferment of systemic retinoids and their accompanying toxic side-effects in childhood.

ISSN:0954-6634    

DOI:10.3109/09546639009086715

出版商:Taylor&Francis    

年代:1990

数据来源: Taylor

摘要:

It is anticipated that the NF-1 gene will be isolated in the near future. The isolation of the NF-2 gene may follow closely behind. The characterization of these genes may lead to new insights into the disease processes and possibly to more rational treatment. Until then, the critical part of the management of these patients is continued support and a vigilant watch for the potentially devastating complications.

ISSN:0954-6634    

DOI:10.3109/09546639009086716

出版商:Taylor&Francis    

年代:1990

数据来源: Taylor

ISSN:0954-6634    

DOI:10.3109/09546639009086717

出版商:Taylor&Francis    

年代:1990

数据来源: Taylor

ISSN:0954-6634    

DOI:10.3109/09546639009086718

出版商:Taylor&Francis    

年代:1990

数据来源: Taylor

摘要:

The indications for retinoids in diseases involving the nails fall into 3 groups: proven use (with sometimes controversial reports); possible use; and suggested use. The complications of the retinoids on the nail apparatus are reviewed and their mechanisms explained.

ISSN:0954-6634    

DOI:10.3109/09546639009086719

出版商:Taylor&Francis    

年代:1990

数据来源: Taylor

摘要:

A 72-year-old man developed an unusual, dramatic and extensive lichenoid eruption and alopecia associated with captopril. Clinically the lesions had a more psoriasiform appearance because of the silvery scales which covered the plaques. The histopathological features of the skin lesions, however, met all the criteria of a lichenoid eruption, including hyperkeratosis and focal parakeratosis, multiple cytoid bodies, liquefaction degeneration of the basal layer, and a dense, band-like infiltrate in the papillary dermis which disturbed the interface between the epidermis and dermis. The causal relationship between captopril and the lichenoid eruption was based mainly on circumstantial evidence, namely, the resistance to therapy even with superpotent steroid ointments as long as the patient continued to receive the drug, and the complete clearing of the eruption within a short time after withdrawal of the drug, using a steroid ointment of low potency. The positive result of the mast cell degranulation test not only gives further support to this causal relationship but also indicates the involvement of an immunological mechanism. Hair loss may occur in lichenoid drug reactions as a result of an inflammatory infiltrate extending around the follicles and ultimately destroying them. Alopecia associated with loss of taste has been reported as a side-effect of captopril treatment attributed to zinc deficiency. Our patient certainly did not have any of these types of hair loss. The cause of the alopecia in our patient remains obscure.

ISSN:0954-6634    

DOI:10.3109/09546639009086720

出版商:Taylor&Francis    

年代:1990

数据来源: Taylor