摘要:

The three factors other than age that are the most important determinants of stroke occurrence are (1) transient cerebral ischemic attacks (TIAs), (2) hypertension, and (3) cardiac disease.In the Rochester population study, a stroke developed during the period of observation in 36% of the patients with TIAs. Fifty-one percent of all the strokes occurred during the first year after the TIA, and 21% occurred during the first month after the first attack.Hypertensive persons have an increased incidence of each of the major atherothrombotic diseases as compared to normotensive persons.During the full 25 years of study of the Rochester population, there was a decrease from the earliest to the latest five-year period of 32% for all strokes in women and 20% in men. This may reflect treatment of this population.

ISSN:0039-2499    

出版商:OVID    

年代:1974

数据来源: OVID

摘要:

The contribution of hypertension to risk of all strokes and of nonembolic brain infarction in elderly black and white men and women is examined.The results of the Chicago Stroke Study show that hypertension is significantly associated with increased risk of nonembolic brain infarction, as well as all stroke, in this population of elderly black and white men and women. It is possible that 25% or more of the total incidence of stroke in persons 65 to 74 years of age may be attributable to hypertension.

ISSN:0039-2499    

出版商:OVID    

年代:1974

数据来源: OVID

摘要:

Hypertension and atherosclerosis are the leading causes of stroke. The risk of stroke is directly related to the height of the blood pressure.The Veterans Administration Cooperative Study included 523 male patients. If the results of two subgroups (115 to 129 mm Hg and 90 to 114 mm Hg initial diastolic) are combined, the total incidence of stroke was 25 in the control group and six in the treated group.In addition to widespread lack of awareness of the medical profession of the benefits of treatment, there also is a failure of detection of hypertension in large segments of our population. There is need for greater professional as well as public education concerning hypertension.

ISSN:0039-2499    

出版商:OVID    

年代:1974

数据来源: OVID

摘要:

The Stroke Project in the Sacramento Medical Center has had two primary objectives. These were: (1) to create an atmosphere of stroke awareness by continuous feedback of relevant and reliable information to physicians who care for stroke patients, and (2) to introduce the concept of the stroke team in daily care of the stroke patient in the hospital and beyond.During a period of two years 171 stroke patients were admitted to the Project. The system devised provided a useful tool in planning objectively the appropriate course of action in patient education and training programs.

ISSN:0039-2499    

出版商:OVID    

年代:1974

数据来源: OVID

摘要:

Blood and whole brain14C and32P activities were determined in hepatectomized rats one, two, five and ten minutes after intravenous (I.V.) injection of14C-labeled L-lactate or D-lactate and32P-labeled rat red blood cells. Whole brain homogenate14C was corrected for blood14C and chemically partitioned into14C-lactate,14CO2and other14C compounds. In controls, lactate was replaced with14C-D-glucose and125l-antipyrine. At one minute postinjection, whole brain14C expressed as percent of total injected14C activity and as percent of the antipyrine value were: antipyrine 1.78% (100%); D-glucose 1.45% (81%); L-lactate 0.36% (20%); and D-lactate 0.13% (7%). One minute after L-lactate injection, brain14C was 74% lactate, 5% CO2and 21% other compounds. Preloading rats with cold racemic Na-lactate reduced L-lactate uptake to 0.14% of the injectate (8% of antipyrine), and reduced D-Iactate uptake to 0.09% (= 5% of antipyrine). At two, five and ten minutes, brain contained more14C with larger fractions metabolized to CO2and other compounds from both L-lactate and D-lactate. The blood-brain barrier appears to contain a saturable lactate carrier exhibiting threefold L-stereospecificity to D-stereospecificity, but resulting in far less net transport than the comparable glucose carrier. Lactate transport may be limited by the scarcity of neutral lactic acid at normal blood pH.

ISSN:0039-2499    

出版商:OVID    

年代:1974

数据来源: OVID

摘要:

Anoxic ischemia with resultant unilateral cerebral infarction was produced in the rat by unilateral ligation of the external and common carotid arteries and exposure of the animal to nitrogen. EEG and behavior were studied for one month after the anoxic insult. Infarcted animals showed prominent circling, contralateral flexion postures, and absent visual and tactile placing. At the end of one month the only persistent clinical abnormality was absent contralateral tactile placing. Acutely the EEG showed loss of normal background activity and high voltage slow waves over the infarcted hemisphere. EEG improvement paralleled clinical improvement. At the end of one month only minor asymmetries were observed in the EEG but sleep spindles remained absent on the infarcted side.

ISSN:0039-2499    

出版商:OVID    

年代:1974

数据来源: OVID

ISSN:0039-2499    

出版商:OVID    

年代:1974

数据来源: OVID

ISSN:0039-2499    

出版商:OVID    

年代:1974

数据来源: OVID

摘要:

This prologue makes clear the factors that provided incentive for creating the Joint Committee for Stroke Facilities to prepare and publish the series of articles appearing regularly inStroke(beginning with the May-June, 1972, issue), best described by the general title of Guidelines for Stroke Care. It points out in admirable fashion the many facets of the disease and will serve to acquaint the reader with the comprehensive nature of the subjects discussed in the “Guidelines.”

ISSN:0039-2499    

出版商:OVID    

年代:1974

数据来源: OVID

摘要:

The Section developed by the Community Health Services Study Group proved to be a difficult, yet important, segment of the “Guidelines.” They have worked diligently to prepare a document which will give communities stimulation, information, and direction in achieving the goals of identifying persons at high risk, preventing stroke, improving care of stroke patients, and providing continuity of care, particularly after the life-threatening phase of illness. The awesome responsibilities facing various health workers and community agencies in after-care are detailed. It is i this area that concerted effort can make an important contribution, particularly in those instances where disability is severe and support from many sources is essential.Although no blueprint can be outlined in a manner which will be universally applicable, this description of facilities and services, if applied imaginatively, should be useful to health planners, hospital trustees, civic leaders, health professionals, and educators in mounting community programs for prevention of stroke and comprehensive care of persons who suffer a stroke.

ISSN:0039-2499    

出版商:OVID    

年代:1974

数据来源: OVID