摘要:

An opportunity to study cerebrovascular changes in sickle cell anemia (SCA) presented itself when a black child with this disorder died of bihemispheric strokes. Angiography demonstrated severe occlusive vascular disease involving primarily the circle of Willis and major bifurcations of both internal carotid arteries. Collateral circulation to the distal branches of the internal carotid arteries occurred through transdural anastomoses from the external carotid system and via the leptomeningeal route. Perfusion of the basal ganglia was accomplished by vessels arising from the proximal internal carotid arteries. These changes resembled those of Moyamoya disease. Autopsy showed old and recent cerebral infarcts. Two vascular processes were responsible for the arterial occlusions: (1) exuberant intimal hyperplasia, and (2) old and recent thrombi with partial recanalization. The former has been described only once before in SCA. Small vessels in the basal ganglia were exceptionally numerous and dilated. We conclude that intimal hyperplasia within large cerebral arteries may be responsible for infarction and small vessel proliferation in basal ganglia in patients with SCA.

ISSN:0039-2499    

出版商:OVID    

年代:1978

数据来源: OVID

摘要:

The reaction of brain parenchymal vessels in areas of no-reflow following ischemia in cats was evaluated. A method was devised by which brain biopsies following ischemia were quickly frozen at −170°C, sections were cut and stained and vessel internal and external diameter measured. Vessels in the no-reflow areas had smaller internal and external diameters and thicker walls when compared to adjacent reflow areas as well as to normal control animals. By utilizing a 2-way analysis of variance in which reflow versus noreflow vessel diameters were compared by region the differences were found to be statistically significant (p< 0.05). The data raise the possibility that there may exist normal regional differences in the size of cerebral vessels.

ISSN:0039-2499    

出版商:OVID    

年代:1978

数据来源: OVID

摘要:

This paper introduces a new index for the assessment of regional cerebral blood flow. The index is proportional to total flow, and is obtained from the ratio of regional count rate to arterial indicator input to a region. This index is a more sensitive indicator of impaired perfusion than the traditional flow rate indices which express flow per unit mass of tissue per minute. It accounts for brain tissue partly or totally deprived of its blood supply. Examples of clinical application are reported. A good correlation with the findings of computer-assisted tomography has been found.

ISSN:0039-2499    

出版商:OVID    

年代:1978

数据来源: OVID

摘要:

Regional brain blood flow was determined in 23 awake, unparalyzed gerbils with a simplified indicator-fractionation technique. The use of intravenous14C-butanol, an indicator that is freely diffusible into the brain, eliminated the need for repetitive sampling of arterial and cerebral venous blood and reduced the period of indicator circulation to 10 seconds. Gerbils spontaneously breathing room air (Paco2= 32 ± I (SE) mm Hg) had blood flows in whole cerebrum, cerebellum, and brainstem of 102 ± 4, 93 ± 5, and 114 ± 6 ml/lOOgm/min respectively. Cerebral blood flow increased linearly with elevations in Paco2(r = 0.969) and averaged 3.14 ± 0.17 ml/lOOgm/min per mm Hg increase in Paco2. Interpolated cerebral blood flow at a Paco2of 40 mm Hg was 127 ± 2 ml/lOOgm/min. This technique is easy and convenient to use, involves no intracrania! surgery, requires steady state conditions for only 10 seconds, and minimizes blood loss in small animals. In more discrete brain regions a less volatile indicator is needed.

ISSN:0039-2499    

出版商:OVID    

年代:1978

数据来源: OVID

ISSN:0039-2499    

出版商:OVID    

年代:1978

数据来源: OVID

摘要:

No Abstract

ISSN:0039-2499    

出版商:OVID    

年代:1978

数据来源: OVID

ISSN:0039-2499    

出版商:OVID    

年代:1978

数据来源: OVID

ISSN:0039-2499    

出版商:OVID    

年代:1978

数据来源: OVID

ISSN:0039-2499    

出版商:OVID    

年代:1978

数据来源: OVID

ISSN:0039-2499    

出版商:OVID    

年代:1978

数据来源: OVID