摘要:

This study has demonstrated that hypothermia with or without circulatory arrest produced ultrastructural alterations in the dog brain. Fluid accumulation in the perivascular area and in the neuropil persists for at least seven days. Neurons in all areas of the brain studied are quite resistant to fluid alterations. Minimal changes occurring in neurons appear to be reversible from these studies with no neuronal necrosis, even with cooling to 10°C. Endothelial cells and oligodendrocytes exhibit essentially normal morphology in all experimental groups. Astrocytes and their processes undergo the most severe alterations, with cellular changes greater in dogs subjected to 60 minutes than to 30 minutes of cardiac arrest, and progressive degrees of damage occurring with increases in postpumping time prior to sacrifice. Our studies indicate cytological damage increases for longer periods posthypothermia than earlier reports which noted a resolution at 72 hours of the edema observed at 24 hours. We have demonstrated with the electron microscope (EM) that edema persists for at least seven days.The application of new developments in the pumping technique such as improved filtering of microemboli may reduce the pathological alterations described in this study and aid the clinical management of patients subjected to hypothermia.

ISSN:0039-2499    

出版商:OVID    

年代:1974

数据来源: OVID

摘要:

A healthy adult with a nevus flammeus presented with a subarachnoid hemorrhage. Cerebral arteriography demonstrated vascular anomalies typical of encephalofacial angiomatosis (Sturge-Weber disease). A review of the literature failed to disclose a welldocumented case of subarachnoid hemorrhage in this condition.

ISSN:0039-2499    

出版商:OVID    

年代:1974

数据来源: OVID

摘要:

Simple hydrogen-sensitive polarographical electrodes of thin platinum wire were inserted into the torcular Herophili of Rhesus monkeys. Hydrogen was administered by inhalation for ten minutes, after which the hydrogen clearance was recorded from torcular blood. At a Paco2of 32 mm Hg (SD ± 2.3), flow in the fast flow compartment was 102 ml/100 gm per minute (SD ± 19.1), and flow in the slow flow compartment was 28 ml/100 gm per minute (SD ± 5.8). Mean total cerebral blood flow was 52 ml/100 gm per minute (SD ± 10.5). Coefficient of variation was less than 10%.Our experience suggests that one may reliably measure average total cerebral blood flow in the experimental setting by following the clearance of hydrogen from torcular blood. The method is relatively simple, inexpensive and radiation-free. It can be easily combined with the standard hydrogen clearance technique for measuring local tissue blood flow, thereby permitting the simultaneous recording of both local and total brain blood flow.

ISSN:0039-2499    

出版商:OVID    

年代:1974

数据来源: OVID

摘要:

The mechanics of breathing and responses of the respiratory system to CO2during resistance breathing were studied in 12 patients with clinical evidence of unilateral cerebral infarction and compared with the findings in normal subjects. The respiratory abnormalities in patients with cerebrovascular disease consisted of noncompliant lungs and high levels of elastic and nonelastic work while rebreathing CO2. There were no differences in responses of minute ventilation to CO2in the two groups. Unlike normal subjects, the patients did not increase their level of respiratory work to compensate for the addition of a modest external resistance to airflow, and the ventilatory response to CO2, consequently, became less than in the normal subjects. This failure to maintain tidal volumes and minute ventilation while breathing through an external resistance may account for some instances of respiratory deterioration among patients with cerebrovascular disease.

ISSN:0039-2499    

出版商:OVID    

年代:1974

数据来源: OVID

摘要:

Meyer JS, Okamoto S, Shimazu K, Koto A, Ohuchi T, Sari A, Ericsson AD: Cerebral Metabolic Changes During Treatment of Subacute Cerebral Infarction by Alpha and Beta Adrenergic Blockade With Phenoxybenzamine and Propranolol. Stroke 5:180–195 (Mar-Apr) 1974.Due to an error in editing, the figures and legends do not correspond in the article by Meyer et al. The legends should be as follows:The legend for figure 8, which appears on page 192, is actually the legend for figure 1, which appears on page 183.The legend for figure 9, which appears on page 193, is actually the legend for figure 2, which appears on page 184.The legend for figure 1, which appears on page 183, is actually the legend for figure 3, which appears on page 187.The legend for figure 2, which appears on page 184, is actually the legend for figure 4, which appears on page 188.The legend for figure 3, which appears on page 187, is actually the legend for figure 5, which appears on page 189.The legend for figure 4, which appears on page 188, is actually the legend for figure 6, which appears on page 190.The legend for figure 5, which appears on page 189, is actually the legend for figure 7, which appears on page 191.The legend for figure 6, which appears on page 190, is actually the legend for figure 8, which appears on page 192.The legend for figure 7, which appears on page 191, is actually the legend for figure 9, which appears on page 193.

ISSN:0039-2499    

出版商:OVID    

年代:1974

数据来源: OVID

ISSN:0039-2499    

出版商:OVID    

年代:1974

数据来源: OVID

ISSN:0039-2499    

出版商:OVID    

年代:1974

数据来源: OVID

ISSN:0039-2499    

出版商:OVID    

年代:1974

数据来源: OVID

摘要:

Fifteen institutions participated in a cooperative study for treatment of single ruptured intracranial aneurysms. Between June, 1963, and February, 1970, 1,005 protocols were submitted to the Central Registry. All patients had a single ruptured aneurysm on the internal carotid, middle cerebral, anterior cerebral-anterior communicating or vertebral-basilar arteries. The four treatments allocated randomly were regulated bed rest, drug-induced hypotension, carotid ligation, and intracranial surgery. This study was an attempt to provide the relative merits of these several modes of therapy.

ISSN:0039-2499    

出版商:OVID    

年代:1974

数据来源: OVID

摘要:

Four selected treatments, namely, regulated bed rest, drug-induced hypotension, carotid ligation, and intracranial surgery, were randomly allocated with respect to location of the aneurysm and interval following last bleed. The objective of the Study was to answer the question. “What mode of treatment offers a patient with a single ruptured intracranial aneurysm during the previous three months the highest probability of optimal results with respect to survival. residual neurological deficit, capacity for self-care, and gainful employment?” Various treatments were suspended at specific intervals when a particular mode of therapy became inferior to the others.A group of 33 patients was disqualified after treatment was randomly allocated. The numbers of protocols remaining for analysis within each treatment category were 202 for regulated bed rest, 309 for drug-induced hypotension, 187 for carotid ligation, and 274 for intracranial surgery.

ISSN:0039-2499    

出版商:OVID    

年代:1974

数据来源: OVID