摘要:

Platelet survival was studied by using "Cr-labeled platelets in stroke-prone spontaneously hypertensive rats (SHRSP), stroke-resistant SHR (SHRSR) and normotensive control rats of the Wistar-Kyoto (WK) strain. Relatively young animals of the same age prior to the development of cerebrovascular lesions (cerebral infarction and/or hemorrhage) were used.Platelet half-life time in SHRSP was slightly but significantly shorter than in any other groups of rats, irrespective of the type of platelet donors. Mean platelet consumption was also significantly increased in SHRSP only. Platelets of SHRSP injected into SHRSR showed normal survival. These data support the concept that the shortened platelet survival in SHRSP is brought about by some extracorpuscular abnormalities. Although the vascular changes in SHRSP could be the most likely explanation for the shortened platelet survival, its mechanism remains to be solved. This investigation suggests that studies of the platelet survival in hypertension may be useful in predicting the development of stroke before its clinical recognition.

ISSN:0039-2499    

出版商:OVID    

年代:1976

数据来源: OVID

摘要:

The records of 179 consecutive patients with acute carotid system cerebral infarction were studied to describe the temporal profile of the clinical events during the first week of the illness. Only those patients admitted to the cerebrovascular hospital service within 36 hours of the onset of the first symptom were included.The neurological status of 39%was stable (unchanged) at the end of seven days; 35%of the patients gradually improved. Nineteen percent had a progressing neurological deficit from the onset which stabilized within 48 hours of onset. Six patients (3%) had a remittingrelapsing course during the first 36 hours. Eight patients (4%%) had a significant late worsening, after 48 hours of stable or improving course.Mortality was 11% for the entire group. However, a high risk of death group was identified - the mortality was 41% for those patients who had any degree of decreased level of consciousness and hemiplegia at the time of admission.

ISSN:0039-2499    

出版商:OVID    

年代:1976

数据来源: OVID

摘要:

The role of the carotid bifurcation chemoreceptors in mediating the cerebrovascular response to altered arterial Pco2has been suggested to be large. In the present study the cerebrovascular response to raised Pco2was measured in a group of baboons before and after bilateral inactivation of the carotid bodies. The results suggest that these chemoreceptors do play a part in the cerebral vasodilator response to raised Pco2. The role of the carotid body, however, appears to be relatively minor as it only accounted for ± 40% of the total response and became significant only at arterial Pco2levels of more than 50 mm Hg.It is postulated that the peripheral chemoreceptors in the carotid bifurcation mediate part of the cerebrovascular response to altered Paco2but that the role is quantitatively small.

ISSN:0039-2499    

出版商:OVID    

年代:1976

数据来源: OVID

摘要:

The rehabilitation outcome of 25 elderly hemiplegic patients discharged from the rehabilitation facilities of an acute general hospital and admitted to a long-term facility hospital was evaluated. Only those patients who had been on a rehabilitation program and were discharged after an average of 11 weeks because of lack of progress or severity of their functional and/or neurological disability were considered for this study. Twenty-two patients were wheelchair bound on admission and severely dependent in most selfcare activities. Improvement in function and performance occurred in ten patients, while 13 patients remained unchanged. Among the improved patients, eight became ambulatory and independent in activities of daily living (ADL), eight became independent from a wheelchair level, and eight returned home or to the community. The average stay of the patients in the chronic rehabilitation care facility was seven months, although all the patients reached their maximum level of performance within six months. It appears from this study that some hemiplegic patients require a long and intensive rehabilitation program.

ISSN:0039-2499    

出版商:OVID    

年代:1976

数据来源: OVID

摘要:

Two experimental models of brain edema have been produced in rats. Some animals underwent bilateral carotid artery ligation (BLCL), while others received extradural compression by a rubber bar. The characteristics of these conditions were compared by Evans blue injection and by the colloidal carbon perfusion method. Although both models produced an increase in the water content of brain tissue, a blood-brain barrier leak to Evans blue was observed only in the compression edema model. The steroid drug, hydrocortisone, diminished the water content of the edematous brain caused by compression but had no effect on that produced by BLCL. The cerebral circulation, as studied by colloidal carbon perfusion, revealed a vasodilation pattern in those animals who underwent bilateral carotid artery ligation, while vascular damage was observed in the compression edema model.

ISSN:0039-2499    

出版商:OVID    

年代:1976

数据来源: OVID

摘要:

Arteriolar diameters and venular erythrocyte velocities in the small pial vessels on the surface of the cat brain were measured by TV methods during induced epileptic seizures through a cranial window. Grand mal seizures maximally dilated arterioles and increased venular erythrocyte velocity up to 400%. High positive correlation existed between changes in CSF hydrogen ion concentration and pial arteriolar diameter, suggesting metabolic regulation of CBF through CSF/interstitial fluid hydrogen ion alterations during the seizure.

ISSN:0039-2499    

出版商:OVID    

年代:1976

数据来源: OVID

摘要:

A patient with diffuse and focal cerebral dysfunction was found to have absent peripheral pulses. Cerebral angiography revealed evidence of an arteritis with bilateral high grade carotid stenosis. When there was no laboratory confirmation of the arteritis, an iatrogenic etiology (ergotism) was suspected. This was later confirmed by the patient. The pertinent literature on ergotism is reviewed, and it is emphasized that ergotism may develop in patients on therapeutic doses of the drug.

ISSN:0039-2499    

出版商:OVID    

年代:1976

数据来源: OVID

ISSN:0039-2499    

出版商:OVID    

年代:1976

数据来源: OVID

ISSN:0039-2499    

出版商:OVID    

年代:1976

数据来源: OVID