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21. |
A possible role of lipid peroxidation in cellular damages caused by cerebral ischemia and the protective effect of alpha‐tocopherol administration. |
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Stroke,
Volume 14,
Issue 6,
1983,
Page 977-982
Yamamoto M,
Shima T,
Uozumi T,
Sogabe T,
Yamada K,
Kawasaki T,
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摘要:
Incomplete global cerebral ischemia was induced by clamping the bilateral common carotid arteries of spontaneously hypertensive rats (SHR) and blood reperfusion was allowed by declamping the arteries after indicated times. To investigate the possible role of lipid peroxidation which causes irreversible ischemic cell injury during ischemia and subsequent reperfusion, cerebral energy metabolism, brain edema, neurological signs and cerebral and serum lipid peroxides were examined. The effect of alpha-tocopherol administration on these parameters was also studied from the standpoint of its action as a free radical scavenger. During ischemia up to 5 hours, cerebral ATP decreased and lactate increased rapidly, and concomitantly neurological signs, such as eye closure and jumping seizures, and slowly progressing brain edema were observed. The level of lipid peroxides in the brain and serum remained practically unchanged during ischemia, although an increasing tendency was noted. When blood reperfusion was allowed 3 hours after ischemia, tissue ATP level was restored only partially (67.4% of normal), but lactate returned to the normal level. The reperfusion resulted in a rapid rise in the lipid peroxide level both in cerebral tissue and serum and also caused a more severe expression of neurological signs. Intravenous injection of alpha-tocopherol (20 mg/kg body weight) 30 minutes prior to ligation of the carotid arteries significantly suppressed the rise in lipid peroxides both in the brain and serum, improved the severely expressed neurological signs, and promoted resynthesis of ATP. These improvements in the parameters were observed only after the reperfusion was made following ischemia for 3 hours.(ABSTRACT TRUNCATED AT 250 WORDS)
ISSN:0039-2499
出版商:OVID
年代:1983
数据来源: OVID
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22. |
Paraplegia associated with intraaortic balloon pump counterpulsation. |
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Stroke,
Volume 14,
Issue 6,
1983,
Page 983-986
Singh B,
Fass A,
Pooley R,
Wallach R,
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摘要:
Two patients developed paraplegia associated with the use of the intraaortic balloon pump. In one patient, transient spinal ischemic episodes ceased after removal of the intraaortic balloon and the second patient apparently sustained spinal cord infarction. Possible etiologic mechanisms include vascular occlusion due to balloon position, arterial spasm, thromboembolic phenomena, hypotension, hypoxia and arterial dissection.
ISSN:0039-2499
出版商:OVID
年代:1983
数据来源: OVID
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23. |
Nerve terminal damage in cerebral ischemiagreater susceptibility of catecholamine nerve terminals relative to serotonin nerve terminals. |
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Stroke,
Volume 14,
Issue 6,
1983,
Page 986-989
Weinberger J,
Cohen G,
Nieves-Rosa J,
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摘要:
The energy-dependent uptake of (3H)-dopamine (DA), (3H)-norepinephrine (NE) and (3H)-serotonin (5-HT) was measured in synaptosomes isolated from either the whole cerebral hemispheres or the striata of gerbils after cerebral ischemia. Ischemic stroke was induced in the Mongolian gerbil by left common carotid ligation. Uptake values in the affected hemisphere (expressed as a percent of the corresponding control hemisphere) were 32.6% for DA, 35.1% for NE, and 52.0% for 5-HT, 16 hours after stroke. The differential reduction in uptake of the catecholamines relative to 5-HT was significant (p less than 0.005). This differential persisted when measures were made on isolated striata from the ischemic and control hemispheres. In the latter measurements, uptake of DA was 20.7% of control and uptake of 5-HT was 44.7% of control. Uptake of both DA and NE were significantly reduced in animals exhibiting milder circling behavior, while uptake of 5-HT was not. There was no significant reduction of uptake in animals subjected to left common carotid ligation not exhibiting signs of stroke. These studies indicate a selective sensitivity of catecholamine nerve terminals to damage in ischemic stroke.
ISSN:0039-2499
出版商:OVID
年代:1983
数据来源: OVID
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24. |
Doppler ultrasound assessment of the internal carotid artery following carotid endarterectomy. |
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Stroke,
Volume 14,
Issue 6,
1983,
Page 990-994
Padayachee T,
Lewis R,
Yates A,
Gosling R,
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摘要:
Doppler-shifted ultrasound with spectral analysis was used to assess the internal carotid arteries of 48 patients who had undergone carotid endarterectomy (58 carotid endarterectomies). Three patients died in the immediate post-operative period, therefore 45 patients, who represented 54 endarterectomies, were assessed for up to six years following surgery (mean–thirty-four months). Ultrasound tests demonstrated total occlusion of the internal carotid artery in 7 patients within the first post-operative week. Sonograms from the supraorbital and common carotid arteries exhibit two peaks during cardiac systole (A and B). The post-operative A/B ratios were abnormal in 24 instances and these were associated with symptoms in seven. Of these 24, 7 developed severe disease in the internal carotid artery during the six year follow-up period; five were associated with symptoms. Post-operative A/B ratios were normal in 23 instances, 19 of which remained normal at follow-up. None of these nineteen developed symptoms. Only patients with abnormal post-operative A/B ratios subsequently developed severe occlusive disease in the internal carotid artery during the follow-up assessment. Thirty-eight patients underwent unilateral carotid endarterectomy, eight of whom had severe internal carotid artery disease at the contralateral bifurcation at the time of carotid endarterectomy. A further four patients developed severe occlusive disease in the contralateral internal carotid artery during the follow-up period, one of whom was symptomatic.
ISSN:0039-2499
出版商:OVID
年代:1983
数据来源: OVID
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25. |
Enovid‐induced exacerbation of the propensity for stroke in low protein fish diet‐fed stroke‐prone/SHR. |
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Stroke,
Volume 14,
Issue 6,
1983,
Page 995-1000
Wexler B,
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摘要:
Weanling, male and female, stroke-prone, spontaneously hypertensive rats (SP/SHR) were fed either a regular diet, a low protein diet derived from fish tissue + 1% saline drinking water, or the fish diet + 1% saline + daily injections of 0.1 mg Enovid/100 g bw/sc. After 48 days, the Enovid-treated animals developed acute and lethal strokes characterized by massive thrombonecrogenic lesions of the parietal lobe. The blood pressure of the Enovid-treated SP/SHR rose most acutely. The low protein fish diet was markedly catabolic and caused hyperlipidemia, hyperglycemia, elevated ACTH and beta-endorphin levels concomitant with reduced gonadotrophic function. Treatment with Enovid caused severe exacerbation of all of the foregoing changes. It is proposed that a low protein fish diet + 1% saline will accelerate the appearance of strokes in SP/SHR and that Enovid will enhance this effect through its anti-gonadotrophic activity and ability to stimulate increased pituitary-adrenal secretion.
ISSN:0039-2499
出版商:OVID
年代:1983
数据来源: OVID
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26. |
Angiographic findings in a young man with recurrent stroke and positive fluorescent treponemal antibody (FTA). |
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Stroke,
Volume 14,
Issue 6,
1983,
Page 1001-1004
Aldrich M,
Burke J,
Gulati S,
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摘要:
A young man with a history of two strokes was found to have serologic evidence of a prior syphilitic infection, abnormal spinal fluid, and angiographic evidence of diffuse intracranial and extracranial angiopathy which we believe was due to tertiary syphilis, although his use of oral amphetamines cannot be ruled out as a contributing factor. This is the first reported case in which angiography has demonstrated both intracranial and extracranial disease arterial disease due to neurosyphilis. Since syphilis can produce diffuse cerebral arterial changes, this diagnosis should be considered in young patients with stroke even when non-treponemal serologic tests are negative.
ISSN:0039-2499
出版商:OVID
年代:1983
数据来源: OVID
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27. |
Transient global amnesia. |
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Stroke,
Volume 14,
Issue 6,
1983,
Page 1005-1007
Logan W,
Sherman D,
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摘要:
Abstract not available.
ISSN:0039-2499
出版商:OVID
年代:1983
数据来源: OVID
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28. |
Local cerebral blood flow by Xenon enhanced CT. |
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Stroke,
Volume 14,
Issue 6,
1983,
Page 1008-1009
Rottenberg D,
Lu H,
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摘要:
Abstract not available.
ISSN:0039-2499
出版商:OVID
年代:1983
数据来源: OVID
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29. |
Hypertensive encephalopathy. |
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Stroke,
Volume 14,
Issue 6,
1983,
Page 1009-1010
Egol A,
Snyder J,
Grenvik A,
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摘要:
Abstract not available.
ISSN:0039-2499
出版商:OVID
年代:1983
数据来源: OVID
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30. |
Mitral valve prolapse and risk of stroke. |
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Stroke,
Volume 14,
Issue 6,
1983,
Page 1010-1012
Wolf P,
Savage D,
Kannel W,
Castelli W,
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摘要:
Abstract not available.
ISSN:0039-2499
出版商:OVID
年代:1983
数据来源: OVID
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