ISSN:0014-312X    

DOI:10.1159/000128646

出版商:S. Karger AG    

年代:1985

数据来源: Karger

ISSN:0014-312X    

DOI:10.1159/000128647

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

Metabolic changes in blood and skeletal muscle of dogs before, during and after tourniquet ischaemia were investigated to obtain further information on cellular metabolic abnormalities and restitution during and following long-lasting blood flow interruptions. Total carbohydrate and glycogen contents in the muscle tissue fell during ischaemia and remained significantly decreased even 1 h after recirculation due to inhibition of glycogen synthetase activity. Muscle glucose concentration remained stable during ischaemia and was significantly elevated 1 h after tourniquet release. In contrast, muscle lactate concentration was elevated during ischaemia and normal after recirculation. Blood lactate, pyruvate and serum inorganic phosphate concentrations increased markedly after tourniquet release and were still significantly elevated 1 h after recirculation, whereas ketone bodies and citric acid cycle intermediates remained unchanged. Tourniquet ischaemia had no effect on muscle phosphate concentration or on the activities of proteases, protease inhibitors or hydrolases in the blood. Nevertheless, our results clearly indicate metabolic abnormalities in the blood and skeletal muscle during 5 h of tourniquet ischaemia and even after 1 h of recirculation.

ISSN:0014-312X    

DOI:10.1159/000128447

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

To study the effect of acute bleeding on the oxygen supply to the skeletal muscle, heparinized dogs were bled via an arterial cannula until mean arterial pressures of 25 and 50 mm Hg below initial value were reached. The shed blood was retransfused in reverse (50, 25 mm Hg) after correction of the acid-base imbalance in the dogs. Oxygen supply to the skeletal muscle was measured by means of a multiwire polarographic electrode placed on the sartorius muscle and was evaluated by means of ptO2 histograms. The ptO2 histograms showed that the oxygen supply to the skeletal muscle is severely impaired after a decrease in mean arterial pressure of 2·5 mm Hg. Further impairment was seen after a decrease in pressure of 50 mm Hg. During retransfusion tissue oxygenation was normalized only after all shed blood was retransfused and the initial mean arterial pressure was reached

ISSN:0014-312X    

DOI:10.1159/000128448

出版商:S. Karger AG    

年代:1985

数据来源: Karger

ISSN:0014-312X    

DOI:10.1159/000128648

出版商:S. Karger AG    

年代:1985

数据来源: Karger

ISSN:0014-312X    

DOI:10.1159/000128649

出版商:S. Karger AG    

年代:1985

数据来源: Karger

ISSN:0014-312X    

DOI:10.1159/000128650

出版商:S. Karger AG    

年代:1985

数据来源: Karger

ISSN:0014-312X    

DOI:10.1159/000128651

出版商:S. Karger AG    

年代:1985

数据来源: Karger

ISSN:0014-312X    

DOI:10.1159/000128652

出版商:S. Karger AG    

年代:1985

数据来源: Karger

ISSN:0014-312X    

DOI:10.1159/000128653

出版商:S. Karger AG    

年代:1985

数据来源: Karger