摘要:

Acute mesenteric ischemia is highly lethal and therefore a serious problem for surgery and intensive care medicine; accordingly its pathophysiology warrants further study. Oxygen free radicals (OFR) play a role in the intestinal mucosal damage that develops during reperfusion after ischemia. Histamine (H) is generally released in various types of tissue ischemia. The link between H release and OFR has only been studied in in vitro systems. We tested the hypothesis that OFR may be involved in H release following reperfusion of the ischemic gut. The artery supplying a segment of the ileum was occluded for 1 or 2 h in anesthetized dogs. On reperfusion, a release of H into the venous effluent of the segment was demonstrated. Pretreatment of the animals with allopurinol (an inhibitor of xanthine oxidase), or with MTDQ-DA [6,6’-methylenebis(2,2-dimethyl-4-methanesulfonic acid sodium-1,2-dihydroquinoline)], a superoxide anion scavenger, or with a combination of allopurinol and MTDQ-DA resulted in an inhibition of H release. We conclude that OFR may play a role in the local H release following intestinal ischemi

ISSN:0014-312X    

DOI:10.1159/000129042

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

The effects of piroxicam on postoperative changes of collagen – measured as hydroxyproline – concentrations were measured around intestinal anastomoses in rats. Piroxicam, in a dose of 2 mg/kg/day, significantly reduced the decrease of hydroxyproline concentrations around colonic anastomoses during the first 3 days after the operation but also reduced the increase of hydroxyproline concentrations observed at day 7 around ileal anastomoses in the control group. 10 mg piroxicam/kg/day resulted in a 100 % lethal peritonitis after the 5th postoperative day. We suggest that piroxicam affects collagen metabolism by inhibiting granulocyte functi

ISSN:0014-312X    

DOI:10.1159/000129043

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

To identify the high-risk group having a large number of cancerous lesions in the stomach, the histopathological characteristics of multifocal gastric cancer in 38 young patients (49 years old or younger, group A) were studied and compared with 204 older patients (at least 50 years old, group B). In terms of the number of foci, patients with over 4 foci (high-risk patients) were more frequent in group A (20%) than in group B (5%, p < 0.05). In 80% of the patients in group A, each focus was near the borderline of both glands (pyloric and fundic glands) and was not always surrounded by intestinal metaplasia, while in 70% of the group B patients the lesions were scattered throughout the stomach and were surrounded by intestinal metaplasia. The carcinogenesis of multifocal cancer in group A, which differs from that in group B, might be stimulated by some strong carcinogenic promoters.

ISSN:0014-312X    

DOI:10.1159/000129044

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

A guinea pig model was developed to document the association of polymorphonuclear neutrophils (PMN) decrease with pulmonary leakage after a sublethal infusion of endotoxin (LPS Escherichia coli 0111:B4, 5 µg/min/kg). A control group was prepared in the same manner and given an infusion of vehicle alone. Severe leukopenia developed, mostly expressed in the neutrophil population. There was a decrease in RBC catalase and fibronectin. Plasma leakage in the lung followed the endotoxin infusion, which could indicate endothelial cell damage. The results from the present study suggest an activation of PMN in endotoxin-infused animals, degranulation and release of toxic oxygen species, resulting in pulmonary plasma extravasation

ISSN:0014-312X    

DOI:10.1159/000129045

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

To study the hemodynamic side effects of mexiletine and disopyramide when administered before cardioplegic arrest 15 dogs underwent sham cardiac surgery with a 90-min period of aortic cross-clamping. 5 dogs served as control, 5 were given 8 mg/kg/day mexiletine and another five 11 mg/kg/day disopyramide for 1 week before surgery. On the day of surgery a continuous infusion was started. After reperfusion treated animals exceeded their preischemic blood pressure and regained their preoperative cardiac output. Compared to control animals left ventricular work was higher in the treated animals after reperfusion. The two tested type I antiarrhythmics tend to add to myocardial protection when given before cardioplegic arrest and do not exhibit negative inotropic side effects.

ISSN:0014-312X    

DOI:10.1159/000129046

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

In order to investigate further the peculiarly limited response of the transplanted pig liver to rejection, this study investigated serial mixed lymphocyte culture (MLC) responses and suppression of phytohaemagglutinin (PHA)-stimulated lymphocytes by serum from transplanted animals. The responses of lymphocytes from liver allografted pigs were compared with those from sham-operated, liver-autografted or kidney auto- or allografted animals for up to 22 weeks postoperatively. Lymphocytes from operated animals were added to cultures of 2 ‘universal’ donors which were not anaesthetised at any time and which remained lymphocyte donors for the period of each operated pig’s survival. After liver allograft, a sustained stimulation of MLC responses was noted which contrasted with the minimal random stimulatory activity seen in the other groups. The response was not seen in lymphocytes from animals subjected to liver autograft. There was a surprising variability in the week-to-week MLC tests of individual animals for which no cause could be found. The serum from liver auto- and allografted pigs had suppressive action on the PHA stimulation of lymphocytes. There was no correlation between the length of survival and the intensity of the pre-operative MLC response. Whilst the biochemical data of liver allografted pigs showed evidence of ongoing hepatocyte damage, the histological changes were less obvious especially in the long-surviving group. This study highlights again the ability of unimmunosuppressed pigs to accept liver allograft and seems to associate this with sustained hepatocyte damage and stimulation of th

ISSN:0014-312X    

DOI:10.1159/000129047

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

Twenty sheep were placed under general anesthesia and five ribs (6–10) were transected at their lateral angle using a pair of rib shears. The fractures were stabilized by titanium wire mesh plates. After 4, 6, 8, 10 and 12 weeks groups of 4 animals were sacrificed and rib samples were prepared for histological examinations. The study showed that the osteosynthesis stabilized the fractures and that the healing is similar to untreated rib fractures. This osteosynthesis method is a good contribution to severe injured chest treatmen

ISSN:0014-312X    

DOI:10.1159/000129048

出版商:S. Karger AG    

年代:1989

数据来源: Karger

ISSN:0014-312X    

DOI:10.1159/000129049

出版商:S. Karger AG    

年代:1989

数据来源: Karger

ISSN:0014-312X    

DOI:10.1159/000129050

出版商:S. Karger AG    

年代:1989

数据来源: Karger

ISSN:0014-312X    

DOI:10.1159/000129041

出版商:S. Karger AG    

年代:1989

数据来源: Karger