摘要:

Two patients with pneumatosis cystoides coli associated with chronic pulmonary disease are described. In both patients, cysts and symptoms recurred after successful treatment with O2. Both patients had exceptionally high expiratory H2 fasting values. On the basis of these and other observations a new hypothesis is proposed for the pathogenesis of the cysts and for their frequent association with chronic pulmonary disease. It is suggested that the cysts result from excessive colonic gas production in a patient unable to excrete this excess gas via the lungs.

ISSN:0014-312X    

DOI:10.1159/000128011

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

The refinement of techniques for extremity surgery makes it urgent to get more information at cell level of the effects of tourniquet times exceeding the usually accepted 90–120 min. Therefore, in the present experiments, the cellular metabolic and functional restitution of canine skeletal muscle after 3 h of complete tourniquet ischemia was studied. During the ischemia and after recirculation, repeated skeletal muscle samples were taken for ATP, CP and lactate analyses. At the same time periods, blood from a regional vein and vena cava was drawn for pH, pyruvate and lactate analyses. Cellular function was evaluated from repeated measurements of transmembrane potentials. The tourniquet ischemia resulted in a rapid decrease of CP to 40% of the initial level within 1 h and a continuous decrease of ATP. The lactate levels increased continuously. The transmembrane potentials decreased from an initial level of -90 to –54 mV. The release of the tourniquet resulted in a hyperemic reaction and a rapid regain of tissue CP and ATP levels within 5 min of recirculation. There was a continuous washout of lactate up to about 1 h after the release and the transmembrane potentials were normalized after about the same time period. The latter parameters indicate that areas of no-reflow persisted for up to 1 h after restored circulation. The results indicate that after a 3-hour tourniquet ischema, the cellular energy metabolism as well as the membrane function are completely normalized after about 1 h of recirculat

ISSN:0014-312X    

DOI:10.1159/000128012

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

The purpose of the present study was to investigate the distribution in the small bowel wall of intracardially injected microspheres with different diameters, and to find a sphere size that could be used for determination of blood flow to the different layers of the bowel wall. Microspheres were injected into the left ventricle of the hearts of cats in the following order of succession, 8–10, 15 + 5, 25 + 5 and 50 + 5 µm. Samples of the proximal part of the jejunum and the distal part of the ileum were examined microscopically, and the size and the location of the spheres recorded. The following distribution of the microspheres was found: villi 6–16 µm, crypt layer 6–20 µm, propria below the crypts and the muscularis mucosa 11–24 µm, submucosa 9–66 µm and muscularis 6–30 µm. Spheres between 8 and 13 µm appeared to be fairly uniformly distributed in the different layers of t

ISSN:0014-312X    

DOI:10.1159/000128013

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

The influence of segmental small intestinal ischemia on the central circulation and on the regional blood flow to consecutive segments of the small intestine in the rat was investigated with the microsphere method. Ischemia was established by ligating 11 arterial mesenteric end arcades, corresponding to one quarter of the total length of the small intestine. The blood supply to different organs and central circulatory variables were determined before, and 10 min, 30 min, 2 h and 14 days after the establishment of the ischemia. After 10 min of ischemia, there was an increase of the blood flow to the segments distal to the ischemic region but after 30 min, this blood flow was the same as the control flow. The central circulatory variables were not affected. After 2 h of ischemia, the blood supply to both the ischemic and the non-ischemic part of the small intestine had deteriorated considerably. Thus, the vascular resistance in the ischemic segments and the segments surrounding it was increased. Cardiac output was reduced by about 50%. In the experimental group investigated 14 days after establishment of the ischemia, the mortality rate was about 50%. In the survivors, the intestinal blood supply had returned to normal.

ISSN:0014-312X    

DOI:10.1159/000128014

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

Radioactive test substances were infused slowly into the duodenum of conscious rats via a permanent catheter starting 2, 12 and 24 h after a standardized laparotomy. Two differently labelled but otherwise identical test substances were used. The first test substance (125I-PVP) was infused for 4 h, the second (131I-PVP) for the remaining 1 h of the 5-hour infusion period. Immediately after the infusion the animals were killed, and the radioactivity emanating from each isotope was recorded from the excised bowel specimen. The bowel length passed by the border zone and the degree of overlap between the labels in this zone were taken as measures of propulsion and mixing, respectively. Propulsion and mixing were uninfluenced by laparotomy as measured 2–7, 12–17 and 24–29 h after laparotomy. The present findings indicate that laparotomy is not followed by a disturbance in the capability of the small bowel to transport and mix chyme, at least when no high demands with respect to chyme volume are req

ISSN:0014-312X    

DOI:10.1159/000128015

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

Standardized ulcers were produced in rats by local application of acetic acid to the serosal surface of the stomach. Ulcers induced at the lesser curvature, the greater curvature or the posterior wall were found to be of similar size after 2 and 4 weeks. In a group of animals the greater omentum was excised just before the application of acid. Omentectomized animals and control animals were examined 24 h, 1, 3 and 6 weeks after ulcer induction. In omentectomized animals, the ulcers were usually healed or very small after 3 and 6 weeks, while in the control animals most of the ulcers were still large. It is concluded that omentectomy leads to a marked acceleration in the healing of gastric ulcers in rats.

ISSN:0014-312X    

DOI:10.1159/000128016

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

The condition of skin autografts and allografts in rats and rabbits was checked by transcutaneous Po2 measurement according to R. Huch, D. W. Lubbers and A. Huch. The tcPo2* values obtained with standardized maximal hyperemia allow conclusions concerning the oxygen supply and thus the vascularization of a transplant. This method seems suitable to monitor the healing of autografts and to register quantitatively the progress of rejection in allografts.

ISSN:0014-312X    

DOI:10.1159/000128017

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

By splenic subcutaneous transposition and ligation of the vascular pedicle, the direct relation spleen-liver was interrupted in rodents infected with malaria. It was demonstrated that in this situation detoxification of the liver and recovery from malaria was evidently hampered by the lack of a direct splenic cell supply, due to retardation of the homing and differentiation in the spleen of precursors of immunologically competent cells. In the presence of blood-borne antigens and/or hepatotoxins, this simple ‘shunt’ operation appears to constitute a serious immunological handicap. However, it may be a useful model for the study of cellular and microenvironmental interrelationships of the immune response versus blood-borne antig

ISSN:0014-312X    

DOI:10.1159/000128018

出版商:S. Karger AG    

年代:1978

数据来源: Karger

ISSN:0014-312X    

DOI:10.1159/000128019

出版商:S. Karger AG    

年代:1978

数据来源: Karger