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1. |
Supradiaphragmatic Stenosis of the Descending AortaThree Different Perspectives |
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Circulation: Journal of the American Heart Association,
Volume 106,
Issue 17,
2002,
Page 124-124
Walter Mildenberger,
Parwis Fotuhi,
Adrian Borges,
Dietmar Kivelitz,
Michael Laule,
Agathe Konietzko,
Gert Baumann,
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ISSN:0009-7322
出版商:OVID
年代:2002
数据来源: OVID
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2. |
CirculationElectronic PagesOctober 22, 2002 |
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Circulation: Journal of the American Heart Association,
Volume 106,
Issue 17,
2002,
Page 2163-2163
James Willerson,
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ISSN:0009-7322
出版商:OVID
年代:2002
数据来源: OVID
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3. |
Carvedilol Prospective Randomized Cumulative Survival (COPERNICUS) TrialCarvedilol as the Sun and Center of the &bgr;-Blocker World? |
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Circulation: Journal of the American Heart Association,
Volume 106,
Issue 17,
2002,
Page 2164-2166
Kai Wollert,
Helmut Drexler,
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ISSN:0009-7322
出版商:OVID
年代:2002
数据来源: OVID
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4. |
Renin-Angiotensin System and Cardiac Rupture After Myocardial Infarction |
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Circulation: Journal of the American Heart Association,
Volume 106,
Issue 17,
2002,
Page 2167-2169
Scott Solomon,
Marc Pfeffer,
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ISSN:0009-7322
出版商:OVID
年代:2002
数据来源: OVID
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5. |
Diseases of the Veins |
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Circulation: Journal of the American Heart Association,
Volume 106,
Issue 17,
2002,
Page 2170-2172
Joshua Beckman,
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ISSN:0009-7322
出版商:OVID
年代:2002
数据来源: OVID
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6. |
The Electrocardiogram 100 Years LaterElectrical Insights Into Molecular Messages |
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Circulation: Journal of the American Heart Association,
Volume 106,
Issue 17,
2002,
Page 2173-2179
Michael Rosen,
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ISSN:0009-7322
出版商:OVID
年代:2002
数据来源: OVID
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7. |
Preprocedural Statin Medication Reduces the Extent of Periprocedural Non–Q-Wave Myocardial Infarction |
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Circulation: Journal of the American Heart Association,
Volume 106,
Issue 17,
2002,
Page 2180-2183
Joerg Herrmann,
Amir Lerman,
Dietrich Baumgart,
Lothar Volbracht,
Rainer Schulz,
Clemens von Birgelen,
Michael Haude,
Gerd Heusch,
Raimund Erbel,
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摘要:
Background—Stenting-related myocardial injury has been recognized as a frequent and prognostically important event, the extent of which depends on microcirculatory impairment in association with platelet aggregation, inflammation, and increased oxidative stress. Recent studies underscored the non–lipid-lowering effects of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) with antithrombotic, antiinflammatory, and antioxidative aspects. Thus, we tested the hypothesis that preprocedural statin therapy is associated with a reduction in the extent of stenting-related myocardial injury.Methods and Results—We stratified 296 consecutive patients who were undergoing stenting of a de novo stenosis according to the preprocedural status of statin therapy (229 statin-treated and 67 control patients). Incidence of periprocedural myocardial injury was assessed by analysis of creatine kinase (CK; upper limit of normal [ULN] 70 IU/L for women, 80 IU/L for men) and cardiac troponin T (cTnT; bedside test; threshold 0.1 ng/mL) before and 6, 12, and 24 hours after the intervention. Relative to control patients, the incidence of CK elevation >3× ULN was more than 90% lower in statin-treated patients (0.4% versus 6.0%,P=0.01). Statin therapy was the only factor independently associated with a lower risk of CK elevation >3× ULN (OR: 0.08, 95% CI: 0.01 to 0.75;P=0.03). The overall incidences of CK and cardiac troponin T elevation were slightly lower in statin-treated than in control patients (14.4% versus 20.9%,P=0.3, and 17.9% versus 22.4%,P=0.5, respectively).Conclusions—Preprocedural statin therapy is associated with a reduction in the incidence of larger-sized, stenting-related myocardial infarctions. Prospective, randomized trials are warranted to further assess this cardioprotective effect of statins in coronary intervention.
ISSN:0009-7322
出版商:OVID
年代:2002
数据来源: OVID
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8. |
Anti–Tumor Necrosis Factor-&agr; Treatment Improves Endothelial Function in Patients With Rheumatoid Arthritis |
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Circulation: Journal of the American Heart Association,
Volume 106,
Issue 17,
2002,
Page 2184-2187
David Hürlimann,
Adrian Forster,
Georg Noll,
Frank Enseleit,
Rémy Chenevard,
Oliver Distler,
Markus Béchir,
Lukas Spieker,
Michel Neidhart,
Beat Michel,
Renate E. Gay,
Thomas Lüscher,
Steffen Gay,
Frank Ruschitzka,
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摘要:
Background—Rheumatoid arthritis (RA) is associated with accelerated atherosclerosis and increased cardiovascular morbidity and mortality. Striking similarities exist in the inflammatory and immunologic response in RA and atherosclerosis. Indeed, adhesion molecules and cytokines, tumor necrosis factor (TNF)-&agr; in particular, are key mediators of joint inflammation and of vascular dysfunction and progression of atherosclerotic vascular disease. Hence, the aim of the present study was to assess the effect of chronic antiinflammatory treatment with the anti-TNF-&agr; antibody infliximab on disease activity and endothelial function in patients with active RA.Methods and Results—Eleven RA patients (mean age 46±5 years; disease duration 9±2 years) with high disease activity despite treatment with stable doses of methotrexate (≤25 mg/wk) and prednisone (≤10 mg/d) were investigated. Clinical status and endothelium-dependent and -independent vasodilation of the brachial artery as assessed by high-resolution ultrasound were measured before and after 12 weeks of infliximab therapy. Flow-mediated vasodilation improved from 3.2±0.4% to 4.1±0.5% (P=0.018), whereas endothelium-independent vasodilation with nitroglycerin and baseline diameter remained unchanged (13.6±1.2% versus 12.8±1.4%,P=0.98, and 3.74±0.15 versus 3.66±0.11 mm,P=0.54, respectively). Disease activity score (DAS28) was significantly reduced, from 5.6±0.3 to 3.5±0.6 (P=0.002). Erythrocyte sedimentation rate and C-reactive protein were lowered from 34±7 to 19±5 mm/h (P=0.04) and from 38±11 to 15±10 mg/L (P=0.08), respectively.Conclusions—This is the first study to show that anti-TNF-&agr; treatment improves endothelial function in RA. The data suggest that in RA, endothelial dysfunction is part of the disease process and is mediated by TNF-&agr;.
ISSN:0009-7322
出版商:OVID
年代:2002
数据来源: OVID
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9. |
Involvement of Endogenous Endothelin-1 in Exercise-Induced Redistribution of Tissue Blood FlowAn Endothelin Receptor Antagonist Reduces the Redistribution |
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Circulation: Journal of the American Heart Association,
Volume 106,
Issue 17,
2002,
Page 2188-2193
Seiji Maeda,
Takashi Miyauchi,
Motoyuki Iemitsu,
Takumi Tanabe,
Yoko Irukayama-Tomobe,
Katsutoshi Goto,
Iwao Yamaguchi,
Mitsuo Matsuda,
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摘要:
Background—Endothelin-1 (ET-1) is a potent endothelium-derived vasoconstrictor peptide. Exercise results in a significant redistribution of tissue blood flow, which greatly increases blood flow in active muscles but decreases it in the splanchnic circulation. We reported that exercise causes an increase of ET-1 production in the internal organ and then hypothesized that ET-1 participates in the exercise-induced redistribution of tissue blood flow. We investigated the effects of acute endothelin-A (ETA)-receptor blockade on regional tissue blood flow during exercise in rats.Methods and Results—Regional blood flow in the kidney, spleen, stomach, intestine, and muscles was measured using the microsphere technique before and during treadmill running of 30 minutes duration at 30 m/min after pretreatment with either an ETA-receptor antagonist (TA-0201; 0.5 mg/kg) or vehicle in rats. Blood flow in the kidney, spleen, stomach, and intestine was decreased by exercise, but the magnitude of the decrease after pretreatment with TA-0201 was significantly smaller than that after pretreatment with vehicle. Furthermore, the increase in blood flow to active muscles induced by exercise was significantly smaller in rats pretreated with TA-0201 than those pretreated with vehicle.Conclusions—The present study revealed that ET-1-mediated vasoconstriction participates in the decrease of blood flow in the internal organs of rats during exercise, and therefore, that these actions of endogenous ET-1 partly contribute to the increase of blood flow in active muscles during exercise. The data suggest that endogenous ET-1 participates in the exercise-induced redistribution of tissue blood flow.
ISSN:0009-7322
出版商:OVID
年代:2002
数据来源: OVID
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10. |
Effect of Carvedilol on the Morbidity of Patients With Severe Chronic Heart FailureResults of the Carvedilol Prospective Randomized Cumulative Survival (COPERNICUS) Study |
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Circulation: Journal of the American Heart Association,
Volume 106,
Issue 17,
2002,
Page 2194-2199
Milton Packer,
Michael Fowler,
Ellen Roecker,
Andrew Coats,
Hugo Katus,
Henry Krum,
Paul Mohacsi,
Jean Rouleau,
Michal Tendera,
Christoph Staiger,
Terry Holcslaw,
Ildiko Amann-Zalan,
David DeMets,
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摘要:
Background—&bgr;-Blocking agents improve functional status and reduce morbidity in mild-to-moderate heart failure, but it is not known whether they produce such benefits in severe heart failure.Methods and Results—We randomly assigned 2289 patients with symptoms of heart failure at rest or on minimal exertion and with an ejection fraction <25% (but not volume-overloaded) to double-blind treatment with either placebo (n=1133) or carvedilol (n=1156) for an average of 10.4 months. Carvedilol reduced the combined risk of death or hospitalization for a cardiovascular reason by 27% (P=0.00002) and the combined risk of death or hospitalization for heart failure by 31% (P=0.000004). Patients in the carvedilol group also spent 27% fewer days in the hospital for any reason (P=0.0005) and 40% fewer days in the hospital for heart failure (P<0.0001). These differences were as a result of both a decrease in the number of hospitalizations and a shorter duration of each admission. More patients felt improved and fewer patients felt worse in the carvedilol group than in the placebo group after 6 months of maintenance therapy (P=0.0009). Carvedilol-treated patients were also less likely than placebo-treated patients to experience a serious adverse event (P=0.002), especially worsening heart failure, sudden death, cardiogenic shock, or ventricular tachycardia.Conclusion—In euvolemic patients with symptoms at rest or on minimal exertion, the addition of carvedilol to conventional therapy ameliorates the severity of heart failure and reduces the risk of clinical deterioration, hospitalization, and other serious adverse clinical events.
ISSN:0009-7322
出版商:OVID
年代:2002
数据来源: OVID
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