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Cardiovascular News |
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Circulation: Journal of the American Heart Association,
Volume 108,
Issue 9,
2003,
Page 1-2
Ruth SoRelle,
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ISSN:0009-7322
出版商:OVID
年代:2003
数据来源: OVID
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2. |
Cardiac Resynchronization TherapyA Patient’s Guide |
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Circulation: Journal of the American Heart Association,
Volume 108,
Issue 9,
2003,
Page 64-66
Julie Shea,
Michael Sweeney,
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PDF (137KB)
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ISSN:0009-7322
出版商:OVID
年代:2003
数据来源: OVID
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3. |
Multislice Spiral Computed Tomography–Assisted Vein Graft Stenting |
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Circulation: Journal of the American Heart Association,
Volume 108,
Issue 9,
2003,
Page 67-68
Riccardo Marano,
Marco Zimarino,
Maria Storto,
Antonio Calafiore,
Lorenzo Bonomo,
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ISSN:0009-7322
出版商:OVID
年代:2003
数据来源: OVID
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4. |
Circulation Announcement PageSeptember 2, 2003 |
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Circulation: Journal of the American Heart Association,
Volume 108,
Issue 9,
2003,
Page 1037-1037
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PDF (4KB)
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ISSN:0009-7322
出版商:OVID
年代:2003
数据来源: OVID
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5. |
World Heart DayA World Heart Federation Enterprise Promoting the Prevention of Heart Disease and Stroke Across the World |
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Circulation: Journal of the American Heart Association,
Volume 108,
Issue 9,
2003,
Page 1038-1040
Antoni Bayés de Luna,
Tak-Fu Tse,
Marianne de Figueiredo,
Mario Maranhão,
Janet Voûte,
Sania Nishtar,
Valentin Fuster,
Philip Poole-Wilson,
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PDF (28KB)
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ISSN:0009-7322
出版商:OVID
年代:2003
数据来源: OVID
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6. |
Explaining Racial Disparities in Coronary Outcomes in Women |
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Circulation: Journal of the American Heart Association,
Volume 108,
Issue 9,
2003,
Page 1041-1043
William Weintraub,
Viola Vaccarino,
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PDF (20KB)
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ISSN:0009-7322
出版商:OVID
年代:2003
数据来源: OVID
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7. |
Resynchronization Therapy for the Treatment of Heart Failure |
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Circulation: Journal of the American Heart Association,
Volume 108,
Issue 9,
2003,
Page 1044-1048
Leslie Saxon,
Kenneth Ellenbogen,
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PDF (230KB)
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ISSN:0009-7322
出版商:OVID
年代:2003
数据来源: OVID
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8. |
Soluble CD40LRisk Prediction After Acute Coronary Syndromes |
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Circulation: Journal of the American Heart Association,
Volume 108,
Issue 9,
2003,
Page 1049-1052
Nerea Varo,
James de Lemos,
Peter Libby,
David Morrow,
Sabina Murphy,
Rebecca Nuzzo,
C. Gibson,
Christopher Cannon,
Eugene Braunwald,
Uwe Schönbeck,
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摘要:
Background—Elevated plasma concentrations of soluble CD40 ligand (sCD40L) indicate increased risk for future cardiovascular events in apparently healthy women. This study tested the hypothesis that plasma sCD40L, alone or in combination with troponin (cTnI) or C-reactive protein (CRP), may identify patients with acute coronary syndromes at heightened risk for recurrent cardiac events.Methods and Results—In a nested case-control study (cases, n=195; controls, n=195) within the OPUS-TIMI16 trial, patients with the prespecified study end points death, myocardial infarction (MI), or congestive heart failure (CHF) within 10 months had significantly higher median (25th, 75th percentiles) sCD40L plasma levels than did controls (0.78 [0.34, 1.73] ng/mL versus 0.52 [0.16, 1.42] ng/mL,P<0.002). After adjustment for other risk predictors and levels of cTnI and CRP, sCD40L levels above median were associated with higher risk for death, MI, and the composite death/MI or death/MI/CHF (adjusted hazard ratios, 1.9 [P<0.05], 1.9 [P<0.001], 1.9 [P<0.001], and 1.8 [P<0.01], respectively). Interestingly, patients with elevated plasma levels of sCD40L and cTnI showed a markedly increased risk of death, MI, or death/MI/CHF compared with patients with the lowest levels of both markers (adjusted hazard ratios, 12.1, 7.2, and 4.3, respectively; allP<0.01).Conclusions—Elevated plasma levels of sCD40L identify patients with acute coronary syndromes at heightened risk of death and recurrent MI independent of other predictive variables, including cTnI and CRP. Notably, combined assessment of sCD40L with cTnI complements prognostic information for death and MI.
ISSN:0009-7322
出版商:OVID
年代:2003
数据来源: OVID
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9. |
C-Reactive Protein Concentration and Cardiovascular Disease Risk Factors in ChildrenFindings From the National Health and Nutrition Examination Survey 1999–2000 |
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Circulation: Journal of the American Heart Association,
Volume 108,
Issue 9,
2003,
Page 1053-1058
Earl Ford,
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摘要:
Background—C-reactive protein is an emerging risk factor for cardiovascular disease. Although the relations between C-reactive protein and other risk factors for cardiovascular disease have been extensively studied in adults, the relations in children are not well understood.Methods and Results—Data from 2846 boys and girls 3 to 17 years of age who participated in the National Health and Nutrition Examination Survey, 1999 to 2000, a cross-sectional survey of the US population, were used. In univariate analyses, significant associations were observed between C-reactive protein concentration—measured with a high-sensitivity assay—and age, body mass index, systolic blood pressure, and triglyceride concentrations in both sexes. In multiple linear regression analyses, body mass index was the best predictor of C-reactive protein concentration. Age was positively associated with C-reactive protein concentration among boys 3 to 17 years of age. Some race or ethnic differences were present as well among boys 8 to 17 years of age and girls 8 to 11 years of age. Systolic blood pressure was positively associated with C-reactive protein among girls 12 to 17 years of age.Conclusions—Among the sociodemographic and cardiovascular disease risk factors, body mass index was the best predictor of C-reactive protein concentration in children.
ISSN:0009-7322
出版商:OVID
年代:2003
数据来源: OVID
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10. |
Antioxidant Vitamins C and E Improve Endothelial Function in Children With HyperlipidemiaEndothelial Assessment of Risk from Lipids in Youth (EARLY) Trial |
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Circulation: Journal of the American Heart Association,
Volume 108,
Issue 9,
2003,
Page 1059-1063
Marguerite Engler,
Mary Engler,
Mary Malloy,
Elisa Chiu,
Monique Schloetter,
Steven Paul,
Markus Stuehlinger,
Ken Lin,
John Cooke,
Jason Morrow,
Paul Ridker,
Nader Rifai,
Elizabeth Miller,
Joseph Witztum,
Michele Mietus-Snyder,
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PDF (94KB)
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摘要:
Background—Hyperlipidemia is associated with endothelial dysfunction, an early event in atherosclerosis and predictor of risk for future coronary artery disease. Epidemiological studies suggest that increased dietary intake of antioxidants reduces the risk of coronary artery disease. The purpose of this study was to determine whether antioxidant vitamin therapy improves endothelial function and affects surrogate biomarkers for oxidative stress and inflammation in hyperlipidemic children.Methods and Results—In a randomized, double-blind, placebo-controlled trial, the effects of antioxidant vitamins C (500 mg/d) and E (400 IU/d) for 6 weeks and the National Cholesterol Education Program Step II (NCEP-II) diet for 6 months on endothelium-dependent flow-mediated dilation (FMD) of the brachial artery were examined in 15 children with familial hypercholesterolemia (FH) or the phenotype of familial combined hyperlipidemia (FCH). Antioxidant vitamin therapy improved FMD of the brachial artery compared with baseline (P<0.001) without an effect on biomarkers for oxidative stress (autoantibodies to epitopes of oxidized LDL, F2-isoprostanes, 8-hydroxy-2′-deoxyguanosine), inflammation (C-reactive protein), or levels of asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide.Conclusions—Antioxidant therapy with vitamins C and E restores endothelial function in hyperlipidemic children. Early detection and treatment of endothelial dysfunction in high-risk children may retard the progression of atherosclerosis.
ISSN:0009-7322
出版商:OVID
年代:2003
数据来源: OVID
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