摘要:

AbstractA 45‐year‐old orthodontist became sensitized during patch tests with (meth)acrylates. Retesting showed that the sensitizing acrylics were methacrylates, namely 2‐hydroxyethyl methacrylate, 2‐hydroxypropyl methacrylate, ethylene glycol dimethacrylate andN,N‐dimethylaminoethyl methacrylate. Acrylates are stronger sensitizers than methacrylates, but the present report indicates that also methacrylates may sensitize at the patch test concentrations used. Accordingly, it may be necessary to use lower (meth)acrylate concentrations for patc

ISSN:0926-9959    

DOI:10.1111/j.1468-3083.1992.tb00628.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

AbstractThe success of the immunofluorescence technique has as its basis a specific immune reaction which is readily influenced by physicochemical variables. In all procedures careful examination with appropriate selection of materials and conjugates and careful observation must be made. Proper controls are required to interpret specific reactions and distinguish these from nonspecific artefacts and other patterns which cause diagnostic confusion. The recognition of immunofluorescence artefact patterns is essential to the trainee who is gaining experience in immunofluorescence microscopy. However, the correct diagnosis in the individual patient is further insured by correlating all the relevant clinical and histological details with the immunofluorescent findings.

ISSN:0926-9959    

DOI:10.1111/j.1468-3083.1992.tb00629.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

AbstractAfter establishment of the importance of circulating and tissue bound immune complexes in the immunopathogenesis of allergic cutaneous vasculitis, endothelial cell cultures and the development of experimental models permitted us to further visualise aspects of cell‐cell interactions, inflammatory mediators and recently studied adhesion molecules, knowledge that might lead to deeper comprehension of the immunology of vasculitis and at the same time open new horizons for therapeutic intervention. In this review, recent data concerning immunologic mechanisms in allergic cutaneous vasculitis are presented. Emphasis is given to anti‐idiotypic antibodies, monocyte‐endothelial cell, neutrophil‐endothelial cell and lymphocyte‐endothelial cell interactions. The implication of cytokines in immune complex mediated inflammation is postulated. Therapeutic attempts with anti‐idiotypic antibodies, cytokine inhibitors or antagonists and monoclonal antibodies against cell surface leukocyte or endothelial molecules might be rewarding in

ISSN:0926-9959    

DOI:10.1111/j.1468-3083.1992.tb00630.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

AbstractIn recent years we have developed the concept of using automated computer assisted image analysis (ACAIA) for hair growth evaluation. The success of this sophisticated technology depends on the quality of the original images that are fed into the mainframe of the image analyzer. Application of immersion oil onto the scalp site to be photographed appears to improve contrast between hair and scalp and has been named ‘Scalp Immersion Proxigraphy’ (SIP) in contrast to crude proxigraphy, that is close‐up photography without application of immersion oil, commonly used for phototrichogram analysis (PT). In this paper, we report evidence indicating that besides thequalitativeimprovement of the image, SIP also contributes to generate more accuratequantitativedata. Such a conclusion was reached after hair growth variables were compared as a function of the photographic method (SIP vs. PT: 16 scalp sites; 5 balding subjects with clinical features consistent with androgen dependent alopecia). Each site was photographed with both techniques immediately after clipping and 48 h later. After image recording, we manually re‐processed the original pictures on transparencies. The original pictures and the transparencies were analyzed with ACAIA. There was a significant difference between methods in terms of evaluation of linear hair growth rate (LHGR; mm/day,n= 1332 bairs; ScheffeF‐test,P<0.05). LHGR recorded with re‐processed SIP pictures (0.317 mm/day) was very close to that measured in our laboratory with micrometric methods. Distorted figures were generated by PT, leading to an underestimation of this parameter by 30% on average (0.224 mm/day). From previous studies, we knew that hair diameter correlates with linear hair growth rate: the thinner the hair fiber, the slower the growth rate. Both variables may be considered as additive in terms of severity of the alopecia. In this comparative trial of two phototrichogram techniques, we showed that linear hair growth rates can only be accurately estimated with SIP. Therefore, SIP should be used instead of crude proxigraphy when a global assessment of hair growth is to be monitored during clin

ISSN:0926-9959    

DOI:10.1111/j.1468-3083.1992.tb00631.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

AbstractReticulate pigmented anomaly of the flexures or Dowling‐Degos disease is an autosomal dominant genodermatosis that has been associated with other uncommon genodermatosis in a spectrum of disorders. The spectrum included Kitamura's acropigmentatio reticularis, pigmentatio reticularis faciei et colli with multiple epithelial cysts and familial multiple follicular hamartoma. Recent reports have confirmed that Dowling‐Degos disease and Kitamura's acropigmentation are the same disease and have enlarged the spectrum to include other minor variants that are reviewed and discus

ISSN:0926-9959    

DOI:10.1111/j.1468-3083.1992.tb00632.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

AbstractYperite, as a chemical weapon, is responsible for severe cutaneous alterations. In this article we review the clinical aspects of mustard gas poisoning and present the electron microscopic changes found in the epidermis and superficial dermis. Sublethal and lethal alterations were present in keratinocytes and melanocytes. Other cytological aspects indicated attempts at cell division and increased metabolic activity. Some atypical features raise the possibility of mutagenesis.

ISSN:0926-9959    

DOI:10.1111/j.1468-3083.1992.tb00633.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

AbstractLymphomatoid papulosis (LyP) is a cutaneous eruption that is clinically benign but histologically malignant. To date, more than 300 cases have been published. About 10–20% of the patients develop a lymphoma. The purpose of this study was to make a clinicopathological study of 18 patients diagnosed with LyP in our hospital from 1973 to 1990, to characterize cellular infiltrates in the lesions, to find clonal populations of T‐cells and to look for predictive factors of malignant lymphoma in LyP patients. Mean age was 48.7 years. The most frequent clinical lesions were papules (88.8%) followed by plaques (38.8%). The localizations were on extremities (100%), trunk (88%), face (22%), palms or soles (11%), perigenital (11%) and scalp (5%). Two patients have been free of disease for more than 5 years. IgA levels are increased in LyP patients. Neither HTLV I nor III can be considered as a cause of the LyP in any of our patients. Associated diseases were found in 6 cases (1 mycosis fungoides, 1 Hodgkin's disease, 2 anaplastic large‐cell lymphoma and 2 large plaque parapsoriasis). Some types of parapsoriasis should be included in the ‘spectrum of Ki‐1 lymphomas’. 52 skin biopsies were studied. 17% were type A of Willemze, 67% were type B and 15% were transitional. In 12 of the samples follicular or perifollicular infiltration was found. Follicular LyP should not be considered as a distinct type of LyP. Vasculitis is an uncommon finding in LyP. In all the cases studied, large atypical cells were CD30 +; 5/7 cases had lostCD5and 4/5 cases had lost CD7. In one case, all T‐cell antigens were negative. Cerebriform mononuclear cells were always recognized by T‐cell antibodies and they were CD30 positive in only two cases. In one case there were more CD8 + than CD4 + cells. In 5 patients skin and blood samples for genetic rearrangement (beta‐T) were taken. Only germinal line was found. We did not find any significant difference between those cases in which malignant lymphoma developed and those in

ISSN:0926-9959    

DOI:10.1111/j.1468-3083.1992.tb00634.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

AbstractOne hundred and twelve renal transplant recipients and 40 patients with chronic renal failure undergoing maintenance haemodialysis were included in this study. Skin infections were the most common complication in renal transplant recipients (67.8%), with fungal infections being the most frequent (58%). Kaposi's sarcoma was found in three of our transplant patients (2.6%); no other skin tumors were observed in our cases. The second most frequent skin complication after infections was acne lesions (43.7%). On the other hand, pallor and dryness were the most common skin signs observed in uraemic patients; fungal infections were found in 15%. No skin neoplasms were found in the uraemic patients. In conclusion, skin infections and Kaposi's sarcoma are more common in renal transplant recipients than in uraemic patients under haemodialysis maintenance treatment.

ISSN:0926-9959    

DOI:10.1111/j.1468-3083.1992.tb00635.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

AbstractImmunologic status of 33 patients with frequently recurring genital herpes (FRGH) and the effect of two different antiviral regimens have been studied. Patients were treated with oral acyclovir capsules, 200 mg 4 times per day for 6 months (group A), or with a combination of oral acyclovir, 200 mg twice per day for 6 months, and intramuscular interferon‐β (IFN‐β), 3 MU daily for 10 days at every disease recurrence (group B). Before treatment, several immunologic abnormalities involving T and B lymphocytes, as well as cytotoxic (NK/K) cells, were observed in all patients. Clinical results confirmed the previously reported efficacy and safety of acyclovir for suppression of episodes of genital herpes. The acyclovir efficacy was enhanced by combination with IFN‐β, which has antiviral and immunomodulatory properties. In our patients with FRGH and cell‐mediated immunity impairment, IFN‐β was able to restore, in part, the host immune deficit with a significant reduction in the number of recurrence of genital herpes episodes (recurrence rate of 19% in group B vs 47% in group A). No significant toxic effects were detected in either therap

ISSN:0926-9959    

DOI:10.1111/j.1468-3083.1992.tb00636.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

AbstractBackground.Tetracyclines are recommended as primary choice for the treatment of venereal chlamydial infections. Erythromycin has been used in high doses as an alternative. Erythromycin acistrate (EA) is a 2′‐acetyl ester prodrug of erythromycin that can be used in lower doses.Objective.To show the efficacy of EA 400 mg twice daily in the treatment of venereal chlamydial infections.Study design.A randomized, double‐blind parallel group study. Chlamydia‐positive patients were randomized to treatment with either EA or erythromycin stearate (ES) for 10 days. Follow up cultures were performed at 28 days after the start of therapy. The sexual consort was treated with erythromycin stearate.Subjects.A total of 151 patients participated (47 males, 104 females). Seventy‐two patients received EA and 79 ES.Intervention.EA (0.4 g) and ES (0.5 g) were given twice daily for 10 days.Results.The bacteriological cure rate was 98% in the EA group and 97% in the ES group. There were no statistically significant differences between the treatment groups. No patient discontinued the medication in either group, although 30% of the EA group and 27% of the ES group reported adverse effects, mainly transient gastrointestinal symptoms.Main outcome.Treatment with erythromycin acistrate or stearate twice daily is a simple and efficient alternative for the treatment of sexually transmitted chlamydial infection in both male and female

ISSN:0926-9959    

DOI:10.1111/j.1468-3083.1992.tb00637.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY