摘要:

AbstractHighly tritium‐labelled oxytocin and lysine‐vasopressin have been synthesized. L‐tyrosine‐3‐3H was prepared from L‐3‐iodotyrosine and tritium gas in methanolic potassium hydroxide with palladium on active carbon as a catalyst. The tritiated oxytocin and lysine‐vasopressin were obtained from the tritiated tyrosine and the heptapeptides of oxytocin and lysine‐vasopressin, respectively, by the p‐nitrophenyl ester method. The peptides had a high degree of purity and the specific radioactivity was 2.9 C/mmole or 5.9 μC/IU for oxytocin and 1.9 C/mmole or 6.5 μC/IU for lysine‐vasopressin. The high radioactivity of the peptides permits extensive studies of their properties in vivo. The stability of the tri

ISSN:0022-2135    

DOI:10.1002/jlcr.2590030102

出版商:John Wiley&Sons, Ltd.    

年代:1967

数据来源: WILEY

摘要:

AbstractDL‐2‐Phenylglycine‐1‐14C was prepared in good yield employing a modified Strecker synthesis. The resolution of DL‐2‐phenylglycine into its pure enantiomorphs was accomplished by the stereoselective enzymatic hydrolysis of the N‐chloroacetyl derivative of the L‐optical isomer using hog

ISSN:0022-2135    

DOI:10.1002/jlcr.2590030103

出版商:John Wiley&Sons, Ltd.    

年代:1967

数据来源: WILEY

摘要:

Abstractδ‐aminolevulinic acid‐4‐14C was built up from phthalimide using K14CN as the radioactive starting material. This method avoids the less practical synthesis via glycine‐14C and its condensation with phthalic anhydride to afford phthalylglycine‐1‐14C whose yield, based on K14CN, is thus considera

ISSN:0022-2135    

DOI:10.1002/jlcr.2590030104

出版商:John Wiley&Sons, Ltd.    

年代:1967

数据来源: WILEY

摘要:

AbstractThe channels ratio method of quench correction has been examined and found to be applicable when a single photomultiplier is used for liquid scintillation counting of carbon‐14 and tritium. The relatively simple equipment is also suitable for assay of doubly labelled compounds provided that quenching is not importan

ISSN:0022-2135    

DOI:10.1002/jlcr.2590030105

出版商:John Wiley&Sons, Ltd.    

年代:1967

数据来源: WILEY

摘要:

AbstractThe preparation and characterization of tritium‐labelled 2‐(o‐chlorophenyl)‐2‐(methylamino) cyclohexanone hydrochloride is described. Under the exchange conditions employed (CF3COOH, 10 c3H2O, Pt), it was expected that the tritium would be distributed between the phenyl and cyclohexanone rings. Our observations indicated that the major portion of the tritium was located in the cyclohexa

ISSN:0022-2135    

DOI:10.1002/jlcr.2590030106

出版商:John Wiley&Sons, Ltd.    

年代:1967

数据来源: WILEY

ISSN:0022-2135    

DOI:10.1002/jlcr.2590030107

出版商:John Wiley&Sons, Ltd.    

年代:1967

数据来源: WILEY

ISSN:0022-2135    

DOI:10.1002/jlcr.2590030108

出版商:John Wiley&Sons, Ltd.    

年代:1967

数据来源: WILEY

ISSN:0022-2135    

DOI:10.1002/jlcr.2590030109

出版商:John Wiley&Sons, Ltd.    

年代:1967

数据来源: WILEY

ISSN:0022-2135    

DOI:10.1002/jlcr.2590030110

出版商:John Wiley&Sons, Ltd.    

年代:1967

数据来源: WILEY

ISSN:0022-2135    

DOI:10.1002/jlcr.2590030111

出版商:John Wiley&Sons, Ltd.    

年代:1967

数据来源: WILEY