摘要:

AbstractOn décrit la préparation de L' acide p‐butoxyphénylacéthydroxamique et du p‐butoxyphénylacétamide marqués par le carbone‐14 enposition α par rapport au groupement p‐butoxyphényl; ces deux composés radioactifs sont destinés à L' étude du métabolisme de L' acide p‐butoxyphénylacéthydroxamique, qui est un médicament anti‐inflammatoire puissant, et du p‐butoxyphénylacétami

ISSN:0022-2135    

DOI:10.1002/jlcr.2590020202

出版商:John Wiley&Sons, Ltd.    

年代:1966

数据来源: WILEY

摘要:

AbstractA method is presented for preparation of L‐xyloascorbic‐4‐3H acid 9.5μC/mg by the exchange of 8 M dipotassium ascorbate in tritiumlabeled water by heating 20 hours at 100°C The data confirms the assumptions of Brenner (8), that alkaline isomerization of ascorbic acid proceeds through a carbanion on carbon‐4. A study of the radiation stability of crystalline ascorbic acid indicates that it is not unusually radiation

ISSN:0022-2135    

DOI:10.1002/jlcr.2590020203

出版商:John Wiley&Sons, Ltd.    

年代:1966

数据来源: WILEY

摘要:

AbstractSome local anaesthetics and amino acids were labelled with tritium by the microwave discharge modification of the Wilzbach technique.The following substances were investigated: local anaesthetics: carbocaine, citanest, l‐cocaine, tetracaine and xylocaine; amino acids: glycine, DL‐α‐alanine, DL‐Leucine, DL‐phenylalanine and DL‐tryptophane.The range of microwave energy used was 4,000 to 270,000 Wsec. The range of specific activities obtained was from 0.2 to 29.4 mC/mM; and for the most used substance, DL‐leucine, from 0.4 to 27.2 mC/mM.The effects of some reaction parameters on the labelling were investigated. Results obtained

ISSN:0022-2135    

DOI:10.1002/jlcr.2590020204

出版商:John Wiley&Sons, Ltd.    

年代:1966

数据来源: WILEY

摘要:

AbstractIn früheren Versuchen wurde der mikrobielle Abbau von Substituenten des aromatischen Ringes von phenolischen Ligninspaltstücken und von Lignin selbst untersucht; hierzu wurden die Substituenten durch14C markiert. Um den Abbau dieser Substituenten mit dem des aromatischen Rings vergleichen zu können, war es notwendig, den Benzolring durch14C zu markieren. Die synthetisierten phenolischen Verbindungen sind in Abbildung 1 zusammengestellt. Die Synthesen hierfür gingen von Ba14CO3aus, das über Acetylen in Benzol überführt wurde. Die Substituenten wurden nach und nach mit verschiedenen Methoden in das Benzol eingeführt. Die Ausbeuten, bezogen auf Ba14CO3, lagen für die synthetisierten Ligninalkolhole für p‐Cumaralkohol bei 18%, für Coniferylalkohol bei 6% und für Sinapinalkohol bei 2%. Die spezifische Aktivität dieser Ligninalkohole betrug 0,1‐0,06 mC/mMol. Die spezifische Aktivität der anderen, in Abbildung 1 gezeigten Verbindungen betru

ISSN:0022-2135    

DOI:10.1002/jlcr.2590020205

出版商:John Wiley&Sons, Ltd.    

年代:1966

数据来源: WILEY

摘要:

AbstractCortexolone‐1, 2‐3H (17α, 21‐dihydroxy‐4‐pregnene‐3,20‐dione) has been used as the starting point for the preparation of tetrahydrocortexolone‐1, 2‐3H and of tetrahydrocortexone‐1, 2‐3H (3α, 17α, 21‐trihydroxy‐5β‐pregnane‐20‐one and 3α, 21‐dihydroxy‐5β‐pregnane‐20‐one). The method used involved the catalytic and LiAlH4reduction of a derivative whose side‐chain was protected by bismethylene‐dioxy groups. The structural proof and radiochemical purity were determined by the radiochromatography of various derivatives

ISSN:0022-2135    

DOI:10.1002/jlcr.2590020206

出版商:John Wiley&Sons, Ltd.    

年代:1966

数据来源: WILEY

摘要:

AbstractOrphenadrine hydrochloride and a related ether were labelled with tritium in the 2‐(dimethylamino)‐ethyl moiety, by reduction of the corresponding amides with tritiated lithium aluminium hydride (yields 72 and 51 %, resp., specific radioactivity 57,8 m C/g in both cases). Hydrolysis of one of the labelled ethers afforded tritiated 2‐(dimethylamino) ethanol (yield 80 %, specific radioactivity 146 m

ISSN:0022-2135    

DOI:10.1002/jlcr.2590020207

出版商:John Wiley&Sons, Ltd.    

年代:1966

数据来源: WILEY

摘要:

AbstractMany difficulties are encountered in the preparation of multilabelled coumpounds, as their purification and analysis for isotopic purity are involved. Another major problem is their self‐radiolysis which can change their composition during storage.This paper describes the preparation of CT4and the analyses which were carried out in order to check its purity : i.e. the mass spectrometric assay and a new gas chromatographic technique employing as detector an ionization chamber coupled with a vibrating reed electrometer. These analyses confirmed the isotopic purity of the CT4prepared, the main impurity being CHT

ISSN:0022-2135    

DOI:10.1002/jlcr.2590020208

出版商:John Wiley&Sons, Ltd.    

年代:1966

数据来源: WILEY

ISSN:0022-2135    

DOI:10.1002/jlcr.2590020209

出版商:John Wiley&Sons, Ltd.    

年代:1966

数据来源: WILEY

ISSN:0022-2135    

DOI:10.1002/jlcr.2590020210

出版商:John Wiley&Sons, Ltd.    

年代:1966

数据来源: WILEY

摘要:

AbstractS‐Ethyl hexahydro‐1H‐azepine‐1‐carbothiolate labelled in the ethyl moiety and in the azepine ring with carbon‐14 was prepared to facilitate residue and metabolism studies. The ethyl labeled compound was prepared in 86% yield and 99+% radiochemical purity. The azepine labeled material was prepared in 60% yield and 99+% radiochem

ISSN:0022-2135    

DOI:10.1002/jlcr.2590020211

出版商:John Wiley&Sons, Ltd.    

年代:1966

数据来源: WILEY