摘要:

AbstractA new synthesis of the alkaloid petaline (14), which includes aStevensrearrangement (5→6) and the preferential O‐demethylation of6, is described.The structures of the by‐products in the demethylation were determined by the use of nmr. and mass spectro

ISSN:0018-019X    

DOI:10.1002/hlca.19700530502

出版商:WILEY‐VCH Verlag GmbH    

年代:1970

数据来源: WILEY

摘要:

AbstractIt is postulated that one aromatic ring and the amine group in the side chain could be sufficient for the specific fixation of the molecule of a tricyclic antidepressant and for warranting its activity. Some partially saturated derivatives of amitriptyline were prepared, in order to check if pharmacologic activity is retained.

ISSN:0018-019X    

DOI:10.1002/hlca.19700530503

出版商:WILEY‐VCH Verlag GmbH    

年代:1970

数据来源: WILEY

摘要:

AbstractSubstitutedo‐tolunitriles are alkylated with 1‐bromomethyl‐cyclohexene. Saponification yields substitutedo‐[2‐(1‐cyclohexen‐1‐yl)‐ethyl]‐benzoic acids, which are cyclised to 1,2,3,4,10,11‐hexahydro‐5H‐dibenzo[a,d]cyclohepten‐5‐ones. Reaction of the latter with (3‐dimethylamino‐propyl)‐magnesium chloride yields, after dehydration, hexahydro derivatives of the known antidepressant amitriptyline. The position of

ISSN:0018-019X    

DOI:10.1002/hlca.19700530504

出版商:WILEY‐VCH Verlag GmbH    

年代:1970

数据来源: WILEY

摘要:

AbstractThe alkylation of the ‘malonyl‐α‐aminopyridines’ (4) gives mixtures of substitution products, mainly the N1‐and O2‐alkyl derivatives. The IR., UV. and NMR. spectra a

ISSN:0018-019X    

DOI:10.1002/hlca.19700530505

出版商:WILEY‐VCH Verlag GmbH    

年代:1970

数据来源: WILEY

摘要:

AbstractThe photochemical behaviour of the nitrite ion must be considered as being similar to that of the carbonyl group. Like the carbonyl group, the nitrite ion inn, π* excitation is capable of abstracting hydrogen atoms from various compounds. During this reaction the nitrite ion is reduced to NO. The radicals obtained by abstracting α‐H atoms from saturated ketones then react with the NO to give nitroso derivatives which undergo a rearrangement to the corresponding oximes ‐ provided that the same carbon bears further hydrogen atoms.Dimethylformamide and probably also acetylacetone act as quenchers in this photoreaction, whereas aromatic aldehydes and excess NO d

ISSN:0018-019X    

DOI:10.1002/hlca.19700530506

出版商:WILEY‐VCH Verlag GmbH    

年代:1970

数据来源: WILEY

摘要:

AbstractThe synthesis of the cycloheptapeptide XI (Figure 1), corresponding to the structure proposed byT. Suzuki et al, for the antibiotic Polymyxin D1is reported. This synthetic compound proved to be identical in all respects with natural Polymyxin D1.

ISSN:0018-019X    

DOI:10.1002/hlca.19700530507

出版商:WILEY‐VCH Verlag GmbH    

年代:1970

数据来源: WILEY

摘要:

AbstractThe synthesis of the tetracyclic spiro compounds11, 12, 13, 14, 17, 18, 19and20with homoproaporphine skeleton is described. Crucial intermediates are the secondary alcohols10and16. The structure of the spiro compounds is proved by transformation of11into the dihydronaphthalene derivative24and NMR.‐spectroscopic studies of the latte

ISSN:0018-019X    

DOI:10.1002/hlca.19700530508

出版商:WILEY‐VCH Verlag GmbH    

年代:1970

数据来源: WILEY

摘要:

AbstractThe synthesis of two metabolites M3and M4of 2,4‐diamino‐5‐(3, 4, 5‐trimethoxybenzyl)‐pyrimidine (trimethoprim,1) is reported. M3(trimethoprim 1‐oxide) as well as the isomeric 3‐oxide were prepared by oxidation of1withm‐chloroperbenzoic acid. The structure of M3was finally established byx‐ra analysis [4]. The metabolite M4[2, 4‐diamino‐5‐(3‐hydroxy‐4, 5‐dimethoxy‐benzyl)‐pyrimidine] was prepared by condensation of 3‐benzyloxy‐4, 5‐dimethoxybenzaldehyde (2) with 3‐methoxypropionitrile (3) and guanidine followed by hydrogenolysis

ISSN:0018-019X    

DOI:10.1002/hlca.19700530509

出版商:WILEY‐VCH Verlag GmbH    

年代:1970

数据来源: WILEY

摘要:

AbstractDie Umsetzung von Natriumbenzylmercaptid mit 1, 6‐2, 3‐Dianhydro‐β‐D‐mannopyranose (IV) führte vorwiegend unter diäquatorialer Öffnung des 2, 3‐Epoxidringes zur 1, 6‐Anhydro‐3‐desoxy‐3‐benzylthio‐β‐D‐altropyranose (XV) und unter diaxialer Öffnung desselben Ringes zur 1, 6‐Anhydro‐2‐desoxy‐2‐benzylthio‐β‐D‐glucopyranose (V). Von den beiden Thio‐Derivaten V und XV wurden mehrere z. T. bekannte Umwandlungsprodukte hergestellt, die in Kombination mit physikalischen Messungen die eindeutige Strukturaufklärung der erwähnten Verbindungen ermöglichten und erstmals zur Synthese der krist. als

ISSN:0018-019X    

DOI:10.1002/hlca.19700530510

出版商:WILEY‐VCH Verlag GmbH    

年代:1970

数据来源: WILEY

摘要:

AbstractThe synthesis of O‐glycyl‐N‐(2, 3, 4‐trihydroxybenzyl)‐hydroxylamine dihydrobromide (3) starting from carbobenzoxy‐glycine and tritylhydroxylamine is described. In contrast to the corresponding isosteric hydrazine derivative1, 3is no decarboxylas

ISSN:0018-019X    

DOI:10.1002/hlca.19700530511

出版商:WILEY‐VCH Verlag GmbH    

年代:1970

数据来源: WILEY