摘要:

AbstractThe synthesis of the heptapeptide H · Met‐Glu(NH2)‐His‐Phe‐Arg‐Try‐Gly · OH (acetate) (VI) comprising the sequence of seven amino acid residues common to ACTH and α‐ and β‐MSH is described in detail. The compound shows a very weak MSH‐activity, no ACTH‐activity, but a very pronounced CRF‐activity (corticotropin re

ISSN:0018-019X    

DOI:10.1002/hlca.19600430602

出版商:WILEY‐VCH Verlag GmbH    

年代:1960

数据来源: WILEY

摘要:

AbstractSubstituted 1‐methyl‐3,4‐dihydro‐isoquinolines can easily be converted to 2‐(β‐acylamido‐ethyl)‐acetophenomes. The latter have been used as intermediates for the synthesis of various substituted 1‐β‐phenylethyl‐2‐methyl‐1,2,3,4‐tetrahydro‐isoquinolines. Several of these compounds show interesting analgesic and spasmolytic properties, especially those containing

ISSN:0018-019X    

DOI:10.1002/hlca.19600430603

出版商:WILEY‐VCH Verlag GmbH    

年代:1960

数据来源: WILEY

摘要:

AbstractAn anomalous type of FRIEDEL‐CRAFTSreaction was observed with hexaethyland hexamethylbenzene. With a number of acid chlorides and γ‐dicarboxylic anhydrides the reaction proceeded by elimination of an alkyl group with production of the corresponding pentaalkylphenyl ketones and γ‐pentaalkylbenzoyl acids respe

ISSN:0018-019X    

DOI:10.1002/hlca.19600430604

出版商:WILEY‐VCH Verlag GmbH    

年代:1960

数据来源: WILEY

摘要:

AbstractBy condensing N–CBO‐nitro‐L‐arginyl‐L‐prolyl‐L‐prolyl‐glycyl azide or the corresponding p‐nitrophenyl ester withL‐phenylalanyl‐L‐seryl‐L‐phenylalanyl‐nitro‐L‐arginine‐p‐nitrobenzyl ester, N‐CBO‐nitro‐L‐arginyl‐L‐prolyl‐L‐prolyl‐glycyl‐L‐phenylalanyl‐L‐seryl‐L‐phenylalanyl‐nitro‐L‐arginine p‐nitrobenzyl ester has been obtained. The same protected octapeptide has also been prepared by condensing N‐CBO‐nitro‐L‐arginyl‐L‐proline withL‐prolyl‐glycyl‐L‐phenylalanyl‐L‐seryl‐L‐phenylalanyl‐nitro‐L‐arginine p‐nitrobenzyl ester. Catalytic hydrogenation of the protected octapeptide affordsL‐arginyl‐L‐prolyl‐L‐prolyl‐glycyl‐L‐phenylalanyl‐L‐seryl‐L‐phenylalanyl‐L‐arginine, the identity of which has been checked by several methods. This octape

ISSN:0018-019X    

DOI:10.1002/hlca.19600430605

出版商:WILEY‐VCH Verlag GmbH    

年代:1960

数据来源: WILEY

摘要:

AbstractThe vibrational spectra of the cyclanones with 5 ≤ n ≤ 15 have been studied in CCl4‐solution, in the CH‐stretching and CH2‐bending regions, using LiF‐ and CaF2‐resolution respectively. Band shapes are found to be complex but fit fairly well with the generally accepted values assigned to CH2‐stretching an ‐bending vibrations. By comparison with some α,α,α′,α′‐tetradeutero‐cyclanones an assignment of the stretching bands of the α‐CH2‐groups is suggested. These groups seem to absorb at about 20 cm−1higher than the normal CH2‐ groups. Possible interpretations for this shift are discussed. The width of the strong absorption regions of the asymmetric and the symmetric stretching vibrations as well as that of the δ(CH2)‐ bendings show pronounced correlation with ring size, exhibiting maximum width for

ISSN:0018-019X    

DOI:10.1002/hlca.19600430606

出版商:WILEY‐VCH Verlag GmbH    

年代:1960

数据来源: WILEY

摘要:

AbstractDie hier beschriebene erneute Untersuchung der chloroformlöslichen Bestandteile der chinesischen KrötengiftdrogeCh'an Suhat durch Kombination der Adsorptionschromatographie an Al2O3mit der präparativen Papierchromatographie die Isolierung von 14 papierchromatographisch einheitlichen Bufogeninen ermöglicht, wovon 13 sich in Kristallen gewinnen liessen. 4 davon konnten zum ersten Mal inCh'an Sunachgewiesen werden. Bei diesen neuen Bufogeninen handelt es sich um Arenobufagin und dessen Artefact Bufarenogin, die schon in anderen Krötengiftsekreten nachgewiesen worden sind, und um zwei vermutlich völlig neue Bufogenine – vorläufig mit den Buchstaben G und H bezeichnet –, die zu Unterschied vom Arenobufagin, das ein 14‐Hydroxysteroid ist, auf Grund des IR.‐Spektrums 14,15‐Epoxysteroide sein dürften. Das früher imCh'an Sunachgewiesene Desacetylbufotalin konnte hier nicht wieder

ISSN:0018-019X    

DOI:10.1002/hlca.19600430607

出版商:WILEY‐VCH Verlag GmbH    

年代:1960

数据来源: WILEY

摘要:

AbstractThe naturally occurring enantiomer of mevalolactone is shown to possess the(R)‐(−)‐configuration XVIII by a direct correlation of its antipode with quinic

ISSN:0018-019X    

DOI:10.1002/hlca.19600430608

出版商:WILEY‐VCH Verlag GmbH    

年代:1960

数据来源: WILEY

摘要:

AbstractReactive dyestuffs containing a sulphofluoride group are fixed on cellulose by a covalent sulphonic ester linkage. Experimental evidence for this conclusion is afforded by the exchange of such a reactive dye for iodine by treatment of the dyed cellulose with NaI in acetone. This reaction is specific for sulphofluoride dyes.

ISSN:0018-019X    

DOI:10.1002/hlca.19600430609

出版商:WILEY‐VCH Verlag GmbH    

年代:1960

数据来源: WILEY

摘要:

AbstractA series of thiazolyl‐oxazoles, most of them having the structural feature NCCN of 2,2′‐bipyridyl known to form metal chelates, has been synthesized by condensation of α‐halogen carbonyl compounds with thioamides of oxazole‐carboxylic acids. The latter were obtained by the method of CORNFORTHand by preparing successively their esters,

ISSN:0018-019X    

DOI:10.1002/hlca.19600430610

出版商:WILEY‐VCH Verlag GmbH    

年代:1960

数据来源: WILEY

摘要:

AbstractThe formation of bivalent iron complexes with the anions of picolinic acid and dipicolinic acid has been described in a preceding publication. The behavior of iron has now been investigated with the aid of oxidation‐reduction potentials FeIII/FeIImeasured in presence of a large excess of the organic ligand on solutions each with constant pH and total [FeIII]t, and over a wide range of variation of these two factors. Dipicolinic acid forms simply the complexes Fe(Dipic)+and Fe(Dipic)2−, already at very low pH‐values. The situation with monopicolinic acid is different. In spite of the bidentate nature of this ligand, only 1:1 and 1:2 complexes are formed with Fe3+, the latter forming Fe(Pic)2OH already below pH = 3, and its dimer Fe2(Pic)4(OH)2if [FeIII]tis above 10−4. The optical behavior of this dimer is very similar to the absorption of Fe2(OH)24+, suggesting an analogous str

ISSN:0018-019X    

DOI:10.1002/hlca.19600430611

出版商:WILEY‐VCH Verlag GmbH    

年代:1960

数据来源: WILEY