摘要:

AbstractA total synthesis of salmon calcitonin is described. The C‐terminal nonapeptide amide 24–32 was coupled with the heptapeptide 17–23. The resulting hexadecapeptide amide 17–32 was reacted with the heptapeptide 10–16 to give the tricosapeptide 10–32. This was condensed with the N‐terminal nonapeptide 1–9, yielding the protected dotriacontapeptide amide 1–32. After removal of the protective groups and purification by gel‐filtration the free peptide obtained exhibited the physical, chemical and biological properties of the natural hormone. Its hypocalcaemic activity (ca. 3500 MRC U/mg) is 20–30 times higher than that of porcin

ISSN:0018-019X    

DOI:10.1002/hlca.19690520702

出版商:WILEY‐VCH Verlag GmbH    

年代:1969

数据来源: WILEY

摘要:

AbstractPhenyl‐azo naphthalene dyestuffs, which are substituted inoand ino′ position by hydroxy and amino (or alkylamino) groups, have been metallised with agents releasing either CoIIions or CoIIIions, the 1:2 complexes formed being examined by means of electrophoresis and alkalimetric titrations. The amino or alkylamino groups are deprotonised only if they are in the naphthalene radical, or, if present in the benzene radical they are acidified by electrophilic substituents. Metallising with CoIIions yielded usually 1:2 CoIIIcomplexes. With one particular dyestuff, however, a 1:2 CoIIcomplex was obtained; it is assumed that this is due to a relatively lower oxidation potential of this dyest

ISSN:0018-019X    

DOI:10.1002/hlca.19690520703

出版商:WILEY‐VCH Verlag GmbH    

年代:1969

数据来源: WILEY

摘要:

AbstractA pentacyclic CoIIIcomplex is described which is comparable with the tetracyclic 1:2 CoIIIcomplex from 2‐aminophenol‐4‐methyl‐sulphone → N‐ethyl‐2‐naphtylamine. Formally, the two ethyl groups of this latter dyestuff are eliminated in the new compound and replaced by a propylene group joining the two amine‐nitrogen atoms together. The pentacycle occurs in two forms: one with a single positive charge and one with a single negative charge. Both amine‐nitrogen atoms are protonated in the cation and deprotonated in the anion. The tetracyclic 1:2 complex cannot form a corresponding cation; it decomposes in acid medium. The stability of the cationoid pentacycle results from a positive chelate effect due to the additional ring. From the comparison of the electron spectra of the pentacyclic and the tetracyclic 1:2 complexes the author concludes that in the pentacyclic complex the azo dyestoff halves have merely undergone a displacement of posi

ISSN:0018-019X    

DOI:10.1002/hlca.19690520704

出版商:WILEY‐VCH Verlag GmbH    

年代:1969

数据来源: WILEY

摘要:

AbstractThe synthesis and some addition reactions of 3‐phenyl‐2‐azanaphtoquinone are desc

ISSN:0018-019X    

DOI:10.1002/hlca.19690520705

出版商:WILEY‐VCH Verlag GmbH    

年代:1969

数据来源: WILEY

摘要:

AbstractThe total lipids from different regions of 6 dolphin brains were extracted and separated into individual fractions. The highest concentration of cerebrosides was found in the cerebral myelin and in the pons, the highest amount of lecithines in the cerebral cortex. After saponification of all fractions, the fatty acid composition was analysed by gas chromatography. The brain regions showed significant differences in relation to their origin.In comparison to the human brain, the brain of the dolphin contains more lipids due to the higher concentration of glycerophosphatides, whereas the contents of sphingolipids are identical in both species.

ISSN:0018-019X    

DOI:10.1002/hlca.19690520706

出版商:WILEY‐VCH Verlag GmbH    

年代:1969

数据来源: WILEY

摘要:

AbstractTwo crystalline diastereomeric N‐methoxy‐3, 3‐di‐methoxycarbonyl‐5‐cyano‐1, 2‐oxazolidines (II and III) have been isolated. The pyramidal arrangement at the respective nitrogen atoms does not invert at room temperature. The ARRHENIUSactivation energy for the epimerization of the thermodynamically less stable isomer to the more stable one in bromoform solution is 29,2 ± 0,5 kcal/Mol (l

ISSN:0018-019X    

DOI:10.1002/hlca.19690520707

出版商:WILEY‐VCH Verlag GmbH    

年代:1969

数据来源: WILEY

摘要:

AbstractCrystals of two interconvertible, diastereomeric N‐methoxy‐3, 3‐di‐methoxy‐carbonyl‐5‐cyano‐1, 2‐oxazolidines have been examined by X‐ray analysis. The lower melting isomer, m.p. 55°, is shown to havetransconfiguration of the methoxy and cyano substituents. Some features of the molecular topo

ISSN:0018-019X    

DOI:10.1002/hlca.19690520708

出版商:WILEY‐VCH Verlag GmbH    

年代:1969

数据来源: WILEY

摘要:

AbstractLinear oligosiloxanes with cyclodisilazane rings built into the siloxane chain were prepared by the reaction of hydroxysilyl substituted cyclodisilazanes in the form of their lithiumsilanolates with dimethyldichlorosilane, α,ω‐chlorosiloxanes or dimethylchlorosilyl substituted cyclodisilaza

ISSN:0018-019X    

DOI:10.1002/hlca.19690520709

出版商:WILEY‐VCH Verlag GmbH    

年代:1969

数据来源: WILEY

摘要:

AbstractThe thermal stability of some types of silicon‐nitrogen compounds was investigate

ISSN:0018-019X    

DOI:10.1002/hlca.19690520710

出版商:WILEY‐VCH Verlag GmbH    

年代:1969

数据来源: WILEY

摘要:

AbstractA displacement chromatography technique is described for the separation of rare earths using the eluent ethylene‐diaminetetraacetate buffered by ammonium acetate to have a determined pH in the separation columns. This method gives concentrations up to 20 g pure rare earth oxides per liter of eluat

ISSN:0018-019X    

DOI:10.1002/hlca.19690520711

出版商:WILEY‐VCH Verlag GmbH    

年代:1969

数据来源: WILEY