摘要:

AbstractThe synthesis of some thioxanthene derivatives as possible metabolites of Methixerc (VI‐hydrochloride) is described. The VON BRAUN degradation of VI with cyanogen bromide leads to the demethyl derivative 9‐ [(3‐piperidyl)‐methyl]‐thioxanthene (VIII). Oxidation of Methixen with hydrogen peroxide at 20° gives a mixture of the two steroisomerie sulfoxides IX and X; they were separated by preparative paper‐chromatography. The same oxidant at 100° oxidizes Methixelz to the sulfone IV. This was also obtained by alkylation of thioxanthene‐10, 10‐dioxide (11). On oxidation with hydrogen peroxide the demethyl derivative VIII affords at 20° the sulfoxide XI (isolated in non‐uniform steric state), and at 100° the sulfone V. Alkylation of thio‐xanthene with N‐methyl‐3‐chloromethyl‐piperidine‐N‐oxide (I) leads to ‐[(N‐ methyl‐3‐piperidyl)‐methyl]‐thioxanthene‐N‐oxide (111), the c

ISSN:0018-019X    

DOI:10.1002/hlca.19630460402

出版商:WILEY‐VCH Verlag GmbH    

年代:1963

数据来源: WILEY

摘要:

AbstractThe absorption spectra ofm‐dimethylaminophenyl‐azo‐azulene in weakly acid solutions have been recorded and the possible structures of its first conjugate acid discussed. In contrast to itsp‐isomer, the compound is protonated mostly on the amino nitrogen, although a measurable amount of the azonium cation is also present. Chemical shifts of the amino methyl protons have been used to demonstrate the difference in protonation of thep‐ andm‐isomers. The proton resonance results are in qualitative agreement with the conclusions drawn from the absorption spectra in the vis

ISSN:0018-019X    

DOI:10.1002/hlca.19630460403

出版商:WILEY‐VCH Verlag GmbH    

年代:1963

数据来源: WILEY

摘要:

AbstractThe structure of the yellow «potassium carbonyl», obtained from CO and K in liquid ammonia, has been shown to be potassium acetylenediolate, KOCCOK. From X‐ray powder‐diagrams a tetragonal cell containing two KOCCOK units witha= 3.93, Å,c= 12.75 Å (space groupI4/mmm) has been derived. The KOCCOK units are arranged parallel to thec‐axis with the following internuclear distnaces: K0: 2.67 and 2.78 Å; KK: 3.65 Å; C

ISSN:0018-019X    

DOI:10.1002/hlca.19630460404

出版商:WILEY‐VCH Verlag GmbH    

年代:1963

数据来源: WILEY

摘要:

AbstractThe synthesis of substituted 1‐[ω‐(nitrophenyl)alkyl]‐l,2,3,4‐tetrahydro‐iso‐quinolines and their resolution into optical antipodes are described. Some of these l‐[ω‐(nitrophenyl)alkyl]‐l,2,3,4‐tetrahydro‐isoquinoline

ISSN:0018-019X    

DOI:10.1002/hlca.19630460405

出版商:WILEY‐VCH Verlag GmbH    

年代:1963

数据来源: WILEY

摘要:

AbstractPrevious investigations of the 1:2‐Cr (and ‐Co) complexes have lead to the conclusion that the azo (and azomethine) dyestuffs which form 56‐rings with the metal atom are arranged perpendicularly to each other (DREW‐PFITZNER disposition). On the other hand those dyestuffs which form 6–6‐rings with the metal atom coordinate in sandwiches, thus making the formation of stereoisomeric 1 : 2‐complexes possible. The critical atomic distances and angles have been calculated and compared with the theoretical values obtained from the coordination octahedron, and found to be in good agreement with the experim

ISSN:0018-019X    

DOI:10.1002/hlca.19630460406

出版商:WILEY‐VCH Verlag GmbH    

年代:1963

数据来源: WILEY

摘要:

AbstractIncubation of microsonics with the supernatant of pH−5‐enzymes is as active in incorporating amino‐acids into proteins (controlled by use of leucin‐[14C]) as incubation with the usual system, which is supplied with pH−5‐enzymes. Since the supernatant of pH−5‐enzymes does not contain any soluble ribonucleic acid (sRNA), all the le∼ciri‐[14C] found in nucleic acids must be hound to microsonial KNA. The behaviour of the isolated microsomal KNA on Sephadex G 75, and of the ribonuclease digest in paper electrophoresis, confirms our suggestion of the presence of an active sRNA fraction in micro

ISSN:0018-019X    

DOI:10.1002/hlca.19630460407

出版商:WILEY‐VCH Verlag GmbH    

年代:1963

数据来源: WILEY

摘要:

AbstractUsing ultra‐violet absorption spectroscopy below 210 mμ it becomes possible to characterize amide chromophores. The present short communication shows that open chain amides and ureas absorb at shorter wave‐lengths than the corresponding cyclic representatives, and that UV. absorption measurements also yield an indication of the degree of acylation in the amide func

ISSN:0018-019X    

DOI:10.1002/hlca.19630460408

出版商:WILEY‐VCH Verlag GmbH    

年代:1963

数据来源: WILEY

摘要:

AbstractThe present paper shows that it is possible to elucidate the tautomerism in the case of hydroxyacyl‐cyclopeptides (open forms‐cyclols‐large rings) with the aid of absorption measurements in the far ultra‐violet spectra

ISSN:0018-019X    

DOI:10.1002/hlca.19630460409

出版商:WILEY‐VCH Verlag GmbH    

年代:1963

数据来源: WILEY

摘要:

AbstractPar hydroxylation de cyclopenténediols‐3,4 et 3,5cisoutrans, on a prèparè 5 cyclopentanetbtrols. L'un d'eux a ètè obtenu aussi par oxydation permanganique du cyclopentadiéne, à côtè d'un èpoxycyclopentanediol qui reprèsente peut‐êre un intermèdiaire. Un cyclopentanetriol et un cyclopentanepentol ont ègalement ètè prèparès. Le mode d'hydrolyse des èpoxydes de la sèrie du cyc

ISSN:0018-019X    

DOI:10.1002/hlca.19630460410

出版商:WILEY‐VCH Verlag GmbH    

年代:1963

数据来源: WILEY

摘要:

AbstractIt has been shown that only a single, relatively unspecific steroid‐oxydase is responsible for both the l2β‐hydroxylation of digitoxigenin and the 15 α‐hydroxylation of deoxycorticosterone by growing cultures ofFusarium lini(BOLLEY). The position of the enzymatic attack is determined by the stereochemistry of the steroid skeleton of the substrate. The transformation of digitoxigenin is much slower than that of deoxycorticosterone. The presence of deoxycorticosterone enhances the oxygenation of digitoxigenin. On the other hand the hydroxylation of deoxycorticosterone is retarded by digito

ISSN:0018-019X    

DOI:10.1002/hlca.19630460411

出版商:WILEY‐VCH Verlag GmbH    

年代:1963

数据来源: WILEY