|
21. |
Effect of Vitamin E on Vascular Integrity in Cholesterol‐Fed Guinea Pigs |
|
Arteriosclerosis and Thrombosis: A Journal of Vascular Biology,
Volume 13,
Issue 12,
1993,
Page 1885-1892
Yan Qiao,
Munehiro Yokoyama,
Kohji Kameyama,
Goro Asano,
Preview
|
PDF (2699KB)
|
|
摘要:
This study was designed to clarify the effects of vitamin E on the alterations in proteoglycan distribution and vascular permeability, which were examined by immunohistochemical and ultrastructural techniques in the aortas of cholesterol-fed guinea pigs. The animals were divided into three groups: a control group, a cholesterol group, and a vitamin E group. Serum levels of cholesterol, triglyceride, low-density lipoprotein, high-density lipoprotein, and thiobarbituric acid-reactive substances were measured. An increase in thiobarbituric acid-reactive substances was observed in the cholesterol group compared with control and vitamin E groups. Intimal atheromatous lesions of the aorta were significantly decreased in the vitamin E group compared with the cholesterol group. Histochemically, an increased distribution of proteoglycans such as chondroitin, dermatan, and heparan sulfates and ruthenium red reaction products in the intima; decreased glycocalyx on the endothelial surface; and increased permeability to horseradish peroxidase were revealed in the cholesterol group compared with the vitamin E group. Hypercholesterolemia, resulting in superoxide production, may have contributed to the endothelial damage and increased permeability to plasma proteins and lipids in the vascular wall of the cholesterol group. However, vitamin E administration inhibited lipid deposition and development of this abnormal permeability associated with an irregular distribution of proteoglycan. These results suggest that vitamin E preserves the morphological and functional integrity of the vascular wall and may contribute to the inhibition of atherogenesis in cholesterol-fed guinea pigs.
ISSN:1049-8834
出版商:OVID
年代:1993
数据来源: OVID
|
22. |
Erratum |
|
Arteriosclerosis and Thrombosis: A Journal of Vascular Biology,
Volume 13,
Issue 12,
1993,
Page 1893-
Preview
|
PDF (17KB)
|
|
ISSN:1049-8834
出版商:OVID
年代:1993
数据来源: OVID
|
23. |
Author Index |
|
Arteriosclerosis and Thrombosis: A Journal of Vascular Biology,
Volume 13,
Issue 12,
1993,
Page 1894-1897
&NA;,
Preview
|
PDF (241KB)
|
|
ISSN:1049-8834
出版商:OVID
年代:1993
数据来源: OVID
|
24. |
Subject Index |
|
Arteriosclerosis and Thrombosis: A Journal of Vascular Biology,
Volume 13,
Issue 12,
1993,
Page 1898-1924
Preview
|
PDF (1927KB)
|
|
ISSN:1049-8834
出版商:OVID
年代:1993
数据来源: OVID
|
25. |
NEWS From the American Heart Association |
|
Arteriosclerosis and Thrombosis: A Journal of Vascular Biology,
Volume 13,
Issue 12,
1993,
Page 1925-1925
&NA;,
Preview
|
PDF (73KB)
|
|
ISSN:1049-8834
出版商:OVID
年代:1993
数据来源: OVID
|
26. |
Meetings Calendar |
|
Arteriosclerosis and Thrombosis: A Journal of Vascular Biology,
Volume 13,
Issue 12,
1993,
Page 1926-1926
Preview
|
PDF (76KB)
|
|
ISSN:1049-8834
出版商:OVID
年代:1993
数据来源: OVID
|
|