|
11. |
Hypogammaglobulinemia and Reduced Numbers of B-Cells in Children With Myelodysplastic Syndrome |
|
Journal of Pediatric Hematology/Oncology,
Volume 23,
Issue 2,
2001,
Page 122-125
Kleebsabai Srivannaboon,
Mary Conley,
Elaine Coustan-Smith,
Winfred Wang,
Preview
|
PDF (59KB)
|
|
摘要:
BackgroundImmunodeficiency in pediatric patients with myelodysplastic syndrome (MDS) has not been described. We report the clinical course of three children with MDS, hypogammaglobulinemia, and reduced numbers of B-cells and B-cell precursors.ObservationsThree patients with recurrent infection who were younger than 1-year-old had MDS of the refractory anemia (RA) subtype diagnosed. All had reduced numbers of circulating B-cells and hypogammaglobulinemia. In two patients, cytogenetic studies revealed a monosomy 7 karyotype and bone marrow studies showed decreased numbers of CD34+ progenitor cells and CD19+ B-cells. Both patients had prolonged courses (7 yrs 10 mos and 6 yrs 9 mos) characterized by recurrent infection and slowly progressive pancytopenia. Both received allogeneic bone marrow transplantation (BMT). The third patient had normal cytogenetic studies and a normal number of CD34+ progenitors but decreased CD19+ B-cells in the bone marrow. She had a stable course with refractory anemia over the course of 7 years.ConclusionsPediatric patients with MDS may have hypogammaglobulinemia and reduced numbers of B-cells. These findings do not preclude a relatively stable and prolonged clinical course. Children with newly diagnosed MDS should have an immunologic evaluation in addition to their hematologic assessment.
ISSN:1077-4114
出版商:OVID
年代:2001
数据来源: OVID
|
12. |
Bilateral Breast Relapse in Acute Myelogenous Leukemia |
|
Journal of Pediatric Hematology/Oncology,
Volume 23,
Issue 2,
2001,
Page 126-129
Philip Monteleone,
David Steele,
Alice King,
Stanley Konefal,
John Kelleher,
Preview
|
PDF (216KB)
|
|
摘要:
We present the case of an 11.5-year-old girl with M1 acute myelogenous leukemia (AML) who had isolated extramedullary relapse develop in both breasts 12 months after diagnosis and 7 months off chemotherapy. She received further chemotherapy, focal radiation therapy, then underwent a matched, unrelated bone marrow transplant and continues in remission 37 months later. Review of the literature revealed 10 cases in other children younger than 21-years-old with AML and breast involvement. These cases are summarized, and potential pathophysiologic mechanisms of spread are discussed. Breast involvement in AML is rare in children. However, regular breast examinations should be performed as part of routine follow-up in all girls with AML.
ISSN:1077-4114
出版商:OVID
年代:2001
数据来源: OVID
|
13. |
Primary Central Nervous System Lymphoma in Childhood Presenting as Progressive Panhypopituitarism |
|
Journal of Pediatric Hematology/Oncology,
Volume 23,
Issue 2,
2001,
Page 130-133
Miriam Silfen,
James Garvin,
Arthur Hays,
Harold Starkman,
Gaya Aranoff,
Lenore Levine,
Neil Feldstein,
Brian Wong,
Sharon Oberfield,
Preview
|
PDF (720KB)
|
|
摘要:
We report a 15-year-old boy who had isolated central diabetes insipidus initially diagnosed at age 11 years. A brain magnetic resonance imaging (MRI) was normal at the time. At age 12 years, growth hormone (GH) testing was performed because of a decline in linear growth rate and demonstrated GH deficiency. After a repeat normal brain MRI, GH therapy was begun. Three years later, hormonal testing revealed prepubertal gonadotropins and low testosterone levels, free thyroxine index, and morning cortisol levels. Repeat brain MRI demonstrated a 9-mm enhancing lesion in the region of the pituitary stalk. The pathologic diagnosis was that of a high-grade malignant B-cell lymphoma, suggestive of Burkitt lymphoma. Growth hormone therapy has not been associated with an increased incidence of lymphoma. This report underscores the need for vigilance in follow-up brain imaging and hormonal evaluation in children with diabetes insipidus, especially those with evolving anterior hormone deficiencies.
ISSN:1077-4114
出版商:OVID
年代:2001
数据来源: OVID
|
14. |
Temporary Response of Localized Intracranial Mast Cell Sarcoma to Combination Chemotherapy |
|
Journal of Pediatric Hematology/Oncology,
Volume 23,
Issue 2,
2001,
Page 134-138
Philipp Guenther,
Angela Huebner,
Stephan Sobottka,
Volker Neumeister,
Gerhard Weissbach,
Horst Todt,
Reza Parwaresch,
Preview
|
PDF (769KB)
|
|
摘要:
Cerebral involvement of systemic mastocytosis and intracranial sarcoma of myelogenic origin are well known entities. An 8-year-old girl with an isolated cerebral mast cell tumor is presented. Specific histopathologic stains were used to confirm the diagnosis detecting immunophenotype and proliferative activity. Treatment with irradiation, intrathecal cytarabine, and interferon-&agr;2b did not induce regression whereas polychemotherapy did. Systemic combination chemotherapy led to marked transient tumor regression in this proliferating mast cell sarcoma in an unusual intracranial location.
ISSN:1077-4114
出版商:OVID
年代:2001
数据来源: OVID
|
15. |
Smooth Muscle Tumor Developing in an Immunocompromised Child After Therapy for Leukemia |
|
Journal of Pediatric Hematology/Oncology,
Volume 23,
Issue 2,
2001,
Page 139-141
Bénédicte Brichard,
Christiane Vermylen,
Serge Gosseye,
Jean Otte,
Guy Cornu,
Preview
|
PDF (130KB)
|
|
摘要:
We report a 5.5-year-old boy who underwent autologous peripheral blood stem cell transplantation for high-risk acute lymphoblastic leukemia and who had two abdominal masses develop 6 months later. Macroscopically complete resection of the abdominal tumors was performed and revealed a well-differenciated leiomyosarcoma. Smooth muscle tumors, benign or malignant, are increasingly recognized in children with various immunodeficiencies; the association with acute lymphoblastic leukemia is rarely described.
ISSN:1077-4114
出版商:OVID
年代:2001
数据来源: OVID
|
16. |
Tumor Lysis Syndrome in an Infant With Langerhans Cell Histiocytosis Successfully Treated Using Continuous Arteriovenous Hemofiltration |
|
Journal of Pediatric Hematology/Oncology,
Volume 23,
Issue 2,
2001,
Page 142-144
Tang-Her Jaing,
Chuen Hsueh,
You-Lin Tain,
Iou-Jih Hung,
Shao-Hsuan Hsia,
Chun-Chieh Kao,
Preview
|
PDF (1356KB)
|
|
摘要:
Langerhans cell histiocytosis (LCH) is an enigmatic disease usually occurring in children. Tumor lysis syndrome (TLS) is a clinical syndrome associated with severe metabolic derangement and oliguric acute renal failure. In this report, we present the clinical course of an infant with advanced LCH who had TLS develop after chemotherapy. Treatment with continuous arteriovenous hemofiltration resulted in effective control of serum uric acid, potassium, creatinine, phosphorus, and blood urea nitrogen levels in the blood.
ISSN:1077-4114
出版商:OVID
年代:2001
数据来源: OVID
|
|