ISSN:0951-7367    

出版商:OVID    

年代:1997

数据来源: OVID

ISSN:0951-7367    

出版商:OVID    

年代:1997

数据来源: OVID

摘要:

In the past year there has been a continued accumulation of data showing regional functional and structural (in older patients) abnormalities in depression.The desired links between altered structure, function and neurochemistry remain elusive but a refined dissection of brain-behaviour relationships is emerging and radiotracers in development will allow a more precise description of the neurochemistry of the depressed state.

ISSN:0951-7367    

出版商:OVID    

年代:1997

数据来源: OVID

摘要:

In the past year, a further seven sites were linked to bipolar illness.Increasingly, it is recognized that mood disorders are multigenic, with only a few families showing determinant genes. Recent studies concentrated on multigenomic linkage studies of genetically isolated pedigrees but future research may be better served by association studies and multicentre co-operation.

ISSN:0951-7367    

出版商:OVID    

年代:1997

数据来源: OVID

摘要:

Neuroendocrine aspects of mood disorders are showing a definite shift from studies that attempt to assess the responsivity of monoamine receptors, especially noradrenaline and 5-hydroxytryptamine, to studies that focus on the primary neuroendocrine stress system, namely, the hypothalamic-pituitary-adrenal axis. Recent research has helped to delineate the subtle changes that take place in this axis in depression, together with the disturbances that may result from such risk factors as maternal deprivation or sexual abuse.

ISSN:0951-7367    

出版商:OVID    

年代:1997

数据来源: OVID

摘要:

The choice of antidepressant is largely governed by its side-effect profile. The predictable and idiosyncratic adverse effects of tricyclic antidepressants, selective serotonin re-uptake inhibitors, monoamine oxidase inhibitors and atypical antidepressants are discussed. Information on the newer agents, such as citalopram, milnacipran, mirtazapine, nefazodone and venlafaxine, is included.

ISSN:0951-7367    

出版商:OVID    

年代:1997

数据来源: OVID

摘要:

The newer antidepressants have fewer side effects than older antidepressants, and are more expensive.We review cost-effectiveness literature comparing newer with older antidepressants, comprising one prospective, four retrospective, and 15 simulation studies. Methodologic issues limit the conclusions that can be drawn from most of these studies. Additional research is needed before it will be possible to consider the question of whether newer antidepressants are cost effective from a societal perspective. From a healthcare system perspective, the limited evidence available tends to suggest that routine first-line treatment with newer antidepressants at current prices may not be cost-effective for the initial and maintenance treatment durations recommended by current practice guidelines. More prospective research is needed before substantial confidence may be placed in this conclusion.

ISSN:0951-7367    

出版商:OVID    

年代:1997

数据来源: OVID

摘要:

Mental disorders are not only common in the general population but are also one of the most prevalent group of conditions seen in primary care populations.The growing awareness of the need to organize services at the primary care level has resulted in a large number of studies of the general population and those attending primary care. The general population studies show that majority of the ill people are not getting treatment. Of those attending primary care, 3-35% are suffering from depressive disorders, with a median value of 10%. Special population groups have higher prevalence rates. Another emerging issue is the comorbidity of anxiety disorders with depressive disorders, alcohol and drug abuse and physical and mental disorders. There is growing recognition of the burden of untreated depression on the individuals and community. Research is also emphasizing the role of social factors as causes. A number of innovative programmes of care and training materials for the primary care personnel have been developed both in developed and developing countries.

ISSN:0951-7367    

出版商:OVID    

年代:1997

数据来源: OVID

摘要:

The main subject of this survey is the discrepancy between the low prevalence of major depression in old age and the high prevalence of minor depression and depressive symptoms, as well as the high incidence of late suicide.It is tentatively explained by the emergence of a new vulnerability to depression, in which physical illness and brain dysfunction gain in importance over genetic and/or personality factors.

ISSN:0951-7367    

出版商:OVID    

年代:1997

数据来源: OVID

ISSN:0951-7367    

出版商:OVID    

年代:1997

数据来源: OVID