摘要:

AbstractWe report a study of strontium kinetics in two patients who received89Sr therapy for disseminated osteogenic sarcoma, together with estimates of absorbed dose to the principal metastases and to bone marrow. In neither patient did tumour uptake of strontium have a significant effect on whole-body retention. In one patient, whole-body strontium kinetics agreed closely with the ICRP standard model, while in the second, retention was extremely prolonged, probably due to hypertrophic osteoarthropathy. Strontium-85 scintigraphy, surface counting and high-resolution whole-body profiles agreed in showing that in both patients tumour turnover of strontium was very rapid, with a biological half-life of only a few days. Absorbed dose to tumour was found to be comparable in magnitude to the mean bone-marrow dose. We have no reason to believe that89Sr therapy was of clinical benefit to either patient.

DOI:10.1259/0007-1285-60-711-253

出版商:The British Institute of Radiology    

年代:1987

数据来源: WILEY

摘要:

This monograph is taken from the proceedings of a National Institutes of Health consensus development conference on adjuvant chemotherapy and endocrine therapy for breast cancer. Nearly all those involved in adjuvant trials attended the meeting, which was held in Washington in September 1985. There are papers on the assessment of clinical trials, steroid hormone receptors, cell kinetics and pathology, as well as the results of some of the major trials.

DOI:10.1259/0007-1285-60-711-260-a

出版商:The British Institute of Radiology    

年代:1987

数据来源: WILEY

摘要:

AbstractLocal control of Ewing's sarcoma was analysed in a series of 67 patients treated by surgery and/or radiotherapy as well as combination chemotherapy. Radiotherapy was employed with or without surgery in 60 patients and produced an overall local control rate of 55%; complete excision of the primary lesion seemed to be beneficial. There was a marked variation in control rates depending on the site of the primary lesion: limb 85%, rib 53%, pelvis 31% and other sites 33%. Primary tumours greater than 10 cm in diameter were significantly less likely to be controlled. Using daily fractions of approximately 180 cGy, total doses in excess of 6000 cGy seem more likely to produce serious late morbidity and may not increase the local control rate. No cases of second malignancy arising in irradiated tissue have been observed to date, but one patient developed acute lymphoblastic leukaemia.

DOI:10.1259/0007-1285-60-711-261

出版商:The British Institute of Radiology    

年代:1987

数据来源: WILEY

摘要:

AbstractThe total-body irradiation (TBI) technique at St Bartholomew's Hospital has been developed to improve dose homogeneity within the patient. Using a standard 6 MV linear accelerator in an orthodox-sized treatment room, the midpoint doses in head, neck, shoulders, mid-mediastinum, pelvis, knees and ankles are ±5% of that of the umbilicus in our current technique. This homogeneity has been achieved by a four-field technique, a reproducible patient set-up, careful use of a new bolus material and an additional beam-flattening filter mounted near the machine head. In addition, thermoluminescent dosimetric data collected at a test irradiation before TBI are used to influence field weightings and further improve dosimetry. This individualised and empirical TBI technique has dosimetric advantages over theoretical TBI dosimetric considerations in reducing dose gradients within the patient. These advantages are discussed.

DOI:10.1259/0007-1285-60-711-269

出版商:The British Institute of Radiology    

年代:1987

数据来源: WILEY

摘要:

AbstractA mathematical model for optimal scheduling of total-body irradiation (TBI) in the treatment of leukaemia is described. A survey of the radiosensitivities of human leukaemic cells indicate that they are highly radiosensitive with little fraction size dependence (medianD0= 0.74 Gy; medianDq= 0.14Gy). These properties, when considered alongside the high repair capacity of lung, suggest that TBI schedules of the “accelerated hyperfractionation” type are optimal. The antileukaemic effects of alternative schedules, chosen to be isoeffective for lung damage to a reference schedule of 6 × 2 Gy in 3 days, were compared. A modestly hyperfractionated schedule of 10 fractions of 1.3–1.5 Gy in 5 days has theoretical advantages while retaining practicality of clinical administration.

DOI:10.1259/0007-1285-60-711-279

出版商:The British Institute of Radiology    

年代:1987

数据来源: WILEY

摘要:

This booklet is fifth in a series dealing with the measurement of performance of diagnostic X-ray systems. It covers those aspects of performance which are specific to conventional tomographic equipment, namely the position, orientation and thickness of the cut “plane” and assessment of the tomographic movement. Spatial resolution and the performance of masking and coning devices are also included, but more general topics such as X-ray tubes, films and screens are dealt with in other reports in the series.

DOI:10.1259/0007-1285-60-711-284-c

出版商:The British Institute of Radiology    

年代:1987

数据来源: WILEY

摘要:

In 1959 Prader et al described for the first time an association of vitamin D-resistant hypophosphataemic rickets with a giant-cell granuloma. Removal of this tumour, located in a rib, led to complete healing of the rickets. Since then such tumours, usually of mesenchymatous origin, have been found in a number of patients with rickets or osteomalacia and the condition has become known under various names such as tumour rickets, oncogenic rickets and tumour-induced hypophosphataemic rickets (or osteomalacia, when it occurs in adults) (Ryan&Reiss, 1984). This condition should be distinguished from X-linked or congenital hypophosphataemic vitamin D-resistant rickets. Marked hypophosphataemia resulting from reduced renal tubular reabsorption of phosphate is the common finding in both conditions and although there are clinical differences between them the diagnosis can sometimes be difficult.Here we describe a patient with congenital hypophosphataemic rickets and a bone lesion which had all the radiological features of a tumour but which proved to be a secondary feature of the disease.

DOI:10.1259/0007-1285-60-711-285

出版商:The British Institute of Radiology    

年代:1987

数据来源: WILEY

摘要:

Superior mesenteric artery (SMA) trunk aneurysms are very uncommon. The last reported incidence was one in 12000 consecutive autopsies (Lucke&Rea, 1921). Aneurysms of its branches are also rare; as far as we are aware, only 40 cases have been mentioned in the literature up to 1980.A case of an aneurysm of the superior mesenteric artery trunk suggested by real-time ultrasound and confirmed by angiography is presented. To our knowledge this is the first case published in which the diagnosis was reached by ultrasound and fine-needle aspiration.

DOI:10.1259/0007-1285-60-711-287

出版商:The British Institute of Radiology    

年代:1987

数据来源: WILEY

摘要:

Dysplasia epiphysealis hemimelica is a developmental disorder of childhood in which there is a symmetrical cartilaginous overgrowth of one or more epiphyses or of a tarsal or carpal bone. The disorder is usually limited to the medial or lateral half of a single extremity and the lesion is microscopically indistinguishable from an osteocartilaginous exostosis. The disorder was first described and called tarsomegaly by Mouchet and Belot in 1926. The purpose of this paper is to report a patient in which the disease involves the ulna. This is very rare.

DOI:10.1259/0007-1285-60-711-288

出版商:The British Institute of Radiology    

年代:1987

数据来源: WILEY

摘要:

Ultrasonography is of proven value in the diagnosis of the acute abdomen in children, notably intussusception and acute appendicitis.This report describes an unusual case of acute, primary, multiple gastric ulcers in a child. Ultrasonography was used in the establishment of the correct diagnosis and in subsequent follow-up.An 11-year-old boy was admitted to our hospital because of sudden onset of severe, epigastric pain preceded by 2 days of diarrhoea and vomiting. On admission, the abdomen was soft, but tender in the upper part. Laboratory tests showed 7100/mm3leucocytes and haemoglobin 11.6 g/dl with haematocrit 49.3%.

DOI:10.1259/0007-1285-60-711-290

出版商:The British Institute of Radiology    

年代:1987

数据来源: WILEY