ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1985.tb04293.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

Previous studies have shown that pretreatment of skin with beta2‐adrenoceptor stimulants antagonizes anti‐human IgE elicited wheal and flare reactions in atopic and non‐atopic subjects. This experimental system was employed to further study the hypothesis that atopic disease and bronchial asthma unrelated to atopy might be associated with a beta‐adrenoceptor defect. Eight patients with extrinsic and 10 patients with intrinsic asthma deprived of oral bronchodilator treatment and corticosteroids for at least a week, and in a clinically stable condition, 10 patients with extrinsic rhinitis and on no treatment, as well as age and sex matched healthy control subjects showed almost identical dose‐response relations for the inhibitory effect of intradermally injected terbutaline (0.25–100 ng), on anti‐IgE elicited skin reactions. In four asthmatic patients the inhibitory effect of terbutaline did not change following a treatment period with oral terbutaline and theophylline. The data do not support the presence of a cutaneous mast cell beta2‐adrenoceptor defect in patients with atopy or bronchial asthma unr

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1985.tb04151.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1985.tb04294.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1985.tb04295.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1985.tb04164.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

The hypothesis of cyclooxygenase derivates of arachidonic acid as putative mediators of late phase skin reactions (LPR) was evaluated by studying the effect of indomethacin and naproxen on anti‐IgE elicited skin reactions in healthy volunteers. Indomethacin 50 mg t.i.d., 48 h prior to and up to 24 h following challenge with anti‐IgE 1/3300 (v/v), produced a slight attenuation of the flare response and a 35% inhibition of the LPR (P<0.05) at 1‐24 h as compared with placebo (n = 11). Naproxen, 250 mg, b.i.d. showed analogous anti‐LPR effect (n = 4, P<0.05). Intradermally (i.d.) injected indomethacin, 75 μg (7 × 10−3mol/1), attenuated the flare and LPR to anti‐IgE 1/330 at 1‐6 h (n = 12, P<0.01). Indomethacin, oral and i.d., enhanced the LPR to various dilutions of anti‐IgE in 30% of the individuals. The results suggest that prostaglandins and thromboxanes participate in the development of an

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1985.tb04152.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1985.tb04296.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

Abstract.The forecasting process includes several aspects. The scientific aspects include (i) a priori observations, like statistics of weather attributes during recent years, variation of earlier atmospheric pollen amounts, and general correlations between weather factors and pollen frequencies. (ii) The present‐day observations are made closer to the flowering season, and they include e.g. the development of the present and forecasted weather, the development of the flower buds, and information obtained from other countries. The practical aspects include effective television, radio and newspaper service, necessary education and information, rapid data analysis and transfer systems, and good national and international cooperatio

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1985.tb04297.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

Killed and live influenza virus vaccines were given to asthmatics and healthy subjects to investigate symptoms and alterations in their respiratory performance after vaccination. Polyvalent killed influenza virus vaccine was given to 16 asthmatics and live attenuated influenza virus vaccine to 23 asthmatics and 21 healthy subjects. Fourteen of the 16 asthmatics vaccinated with the killed vaccine displayed a significant rise in serum antibody level as measured by a single radial haemolysis in gel (SRH test). 11 of the 23 asthmatics and 14 of the 21 healthy subjects vaccinated with the live attenuated vaccine displayed a significant rise in the SRH test. Among the subjects with no measurable initial antibodies and with a significant rise in the SRH test, one asthmatic vaccinated with the killed vaccine experienced symptoms of common cold with fever and dyspnoea 1 week after vaccination. Three asthmatics and four healthy subjects vaccinated with live attenuated vaccine experienced mild symptoms, mainly rhinorrhoea, cough and sore throat 2 to 3 days after vaccination. No alterations in specific airway conductance in asthmatics or in healthy subjects were observed. We conclude that both killed and live attenuated influenza virus vaccines are tolerated well by asthmatics and appear to be safe for asthma patients.

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1985.tb04153.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1985.tb04298.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY