摘要:

In 6 normal subjects and 6 patients with allergic rhinitis, nasal response to insumation of paf‐acether (paf, platelet‐activating factor), lyso‐paf and histamine was evaluated. Nasal challenge with paf, at doses of 300 and 600 nM, induced nasal obstruction, associated with an increase in nasal airway resistances, measured by antherior passive rhinomanometry. Maximum increase in nasal airway resistance was observed at 30 min after challenge (mean percent change + 481 with 600 nM paf;P<0.05). Other symptoms induced by paf insumation were rhinorrhea (6 out of 12 subjects), itching (8 out of 12), sneezing (4 out of 12) and a burning sensation (6 out of 12). No differences were observed between normal and rhinitic subjects, concerning nasal sensitivity to paf. Neither nasal symptoms nor changes in nasal airway resistance were observed after nasal challenge with lyso‐paf (300 and 600 nM); by contrast, histamine (100 nM) induced sneezing, nasal obstruction, itching and rhinorrhea in all the studied subjects, associated with an increase in nasal airway resistance (maximum 5 min after challenge; percent change + 358;P<0.02). Nasal effects of paf were not mediated by histamine, since no increase in histamine levels was observed in nasal washings following paf insufflation. We conclude that paf may have pathogenetic relevance in allergic r

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1991.tb04363.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

We present a non‐atopic 85‐year‐old woman, with a late‐onset recidivant tongue angio‐edema due to pomegranate intake, as proven by a double blind oral challenge test. This is the first case ever reported about adverse reaction to pomegranate. We have been unable to demonstrate an IgE‐mediated mechanism (prick test, histamine release test and RAST with pomegranate were all negative). We emphasize the importance of clinical history and oral challenge test in the diagnosis of f

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1991.tb04364.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

Scratch tests (SCT) with powdered commercial spices were performed in 70 patients with positive skin tests to birch and/or mugwort pollens and celery. Positive SCT to aniseed, fennel, coriander and cumin ‐ all from the same botanical family (Apiaceae) as celery ‐were observed in more than 24 patients. Spices from unrelated families (red pepper, white pepper, ginger, nutmeg, cinnamon) elicited positive immediate skin test reactions only in three of 11 patients. Specific serum IgE to spices (determined in 41 patients with positive RAST to celery) up to class 3 were seen especially in patients with celery‐mugwort or celery‐birch‐mugwort association, and concerned various botanical families. Celery‐birch association pattern was linked to positive reactions (RAST classes 1–2) to spices from the Apiaceae family only.CLINICAL ASPECTSAllergy to spices is often observed in celery‐allergic patients. In cases with the mugwort‐celery association pattern several high RAST values (up to class 3) were seen to various spices from Apiaceae as well as from unrelated botanical families (celery‐mugwort‐spices association). This sensitization can be of clinical importance, as anaphylactic reactions to spices in food are well documented. The birch‐celery association pattern gave some positive RAST results of classes 1–2 to the spices from the Apiaceae family only ‐ suggesting cross‐reactivity between Apiaceae and Betulaceae, probably

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1991.tb04365.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1991.tb04366.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY