ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1983.tb01599.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

Thirteen out of 28 persons (14 men and 14 women) employed in a company which imports, prepares and distributes plant products used in spices and as ingredients in so‐called health food, had developed work‐related symptoms in the form of rhinitis, conjunctivitis, asthma, itch or urticaria. The symptoms occurred in connection with specific work operations, especially in the grinding and packaging of buckwheat. Seven out of 25 examined persons (28%) had at least one positive allergy test (prick test or RAST) against buckwheat. Furthermore, one person had positive RAST against extract form cas5tor‐oil bean. The correlation between positive allergy tests and work‐related symptoms is significant. Fourteen persons were also patch tested. All were negative except one person who had a positive patch test against nickel. The nickel allergy was diagnosed before this study was done and had no relation to the work. The levels of airborne dust in the breathing zones of the workers when they performed dust‐forming work were around and below 5 mg/m3. When buckwheat flour was packaged, the airborne dust levels were about 1–2 mg/m3. Thus, exposure to comparatively low levels of buckwheat dust may induce a definite risk of rapidly ensuing allergy. It is also obvious that persons without atopic stigmata, such as an earlier history of allergy or the occurrence of allergic diseases in relatives, risk becoming allergic. A conclusion is that health food could be a danger, when it

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1983.tb01600.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

Fourteen adults and 10 children with active atopic dermatitis entered this double blind cross‐over study of oral disodium cromoglycate (DSCG) (adults 200 mg qid, children 100 mg qid) compared with placebo. Oral DSCG and placebo were given for 6 weeks in random order. According to the investigators' assessments of eczema, significant differences between active and placebo were found after 6 weeks' treatment. DSCG being favoured (P<0.05). No differences were detected in the investigators' assessment of lichenization and overall disease. No significant. Results form food allergic patients were similar to those from non‐food allergic patients. Two patients reported possible side effects of arthralgia and urticaria respectively. There were no treatment effects on serum IgE values or any other laboratory d

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1983.tb01601.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

Skin sensitivity to apple, carrot and potato, clinically related to birch pollinosis was investigated. Different skin test techniques using fresh fruit were compared. A simple prick test (SPI) technique with a lancet piercing the apple peel just before pricking the skin was shown to be the most practical and to give reproducible results. The allergenic activity in apple was found to be heat labile and deteriorated during storage at room temperature, Apple, carrot, potato, hazelnut and birch reactivity was transferable in Prausnitz‐Küstner test like IgE antibodies. SPT reactivity to fresh material from apple, carrot and potato was investigated in 174 children of whom 128 suffered from pollen allergy. Positive SPT results were obtained almost exclusively in children who were SPT positive to a birch pollen extract. Children who noticed clinical symptoms when eating apple, raw carrot or potato were found to have a significantly larger SPT reaction than children with a negative histo

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1983.tb01602.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

AN automated particle counting immunoassay (PACIA) for measurement of blocking antibodies (antigen neutralizing capacity) against timothy grass pollen extract in sera from desensitized allergies is described.Latex particles coated with E(ab')2‐anti‐timothy are agglutinated by timothy. Serum containing anti‐timothy antibodies inhibits the agglutination. Non‐agglutinated particles are counted in a modified Auto Counter. Nineteen of 20 sera from timothy allergies who had undergone immunotherapy with purified timothy extract for 30 weeks, showed significant agglutination‐inhibition. None of 42 normal human sera gave significant inhibition. The inhibiting antibody could be removed by absorption with protein A and was thus of non‐ IgE nature, i.e. blocking antibody. The results obtained correlated statistically significantly with those found with a double‐antibody method (rS= 0.62,n= 20,t= 3.35,P<0.01) and with the cumulated dosage of timothy allergen extract administered to the individual patient (rS= 0.56,n= 20,t= 2.87,P<0.02). Between‐assay coefficient of variation was from 6.4% to 18.3%. The capacity is 40 samples per hour. The method has also been applied to measurement of blocking antibodies to boney bee

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1983.tb01603.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

A crossed radioimmunoelectrophoretic method was developed for detection of honey bee venom specific IgG antibodies in patient sera. At the serum concentration 1/200 the contrast between specific binding and background was the most favourable. The detection limit was fairly low, approximately 30 kU/1 (IgG RAST units). A reference system based on the reference kits in Phadebas IgG‐RAST® was elaborat

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1983.tb01604.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

In order to evaluate whether children can be taught the efficient use of a pressurized terbutaline aerosol with a tube spacer 71 children were given careful instruction in aerosol inhalation technique according to the manufacturer's instructions. Inhalation technique, was assessed as being efficient when a child achieved an increase of more than 19% in FEV110 min after taking two puffs of terbutaline (each puff = 0.25 mg). After instruction about 37% of children aged 5–7 years and about 80% of children over 7 year were efficient in inhalation technique. Inhalation through the nose after actuation into the mouth accounted for about 50% of treatment failures, with the problem being more frequent in the younger age group. When this error was corrected about 83% of the children were efficient in the technique. Coordination problems and too rapid inspiration after actuation were also common errors. The findings stress the importance of checking all children's inhalation technique before prescribing inhalation therapy. Careful instruction was not enough. The possibility of nasal inhaling should be borne in mind when looking for causes of treatment failur

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1983.tb01605.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

During a 21‐year period in Denmark a total of 26 deaths were caused by wasp or bee stings (according to the National Health Service). The deaths might be classified, with some overlapping, as caused by either anaphylactic/anaphylactoid shocks (between 65% and 80%), suffocation after stings in the airways (about 15%) or preexisting diseases, especially arteriselerotic heart disease (approx 20%). Characteristically, in most persons with shock reactions uncosciousness and death occurred very shortly after the sting (within 45 min), while the interval between sting and death was longer (30 min to a couple of hours) when death was caused by suffocation.In more than 21 of the 26 cases it seemed reasonable to assume the insect allergymighthave contributed to the fatal outcome. Six of these cases had a previous history of abnormal reactions to insect venom, thus only a small group would have benefited from the prophylactic effect of hyposensitisation. There was no known previous history of reactions to insect stings in the other cases, but it is likely that more than six persons had had severe reactions to insect stings on other occasions.Presumably many deaths where insect stings have been involved – though not verified as causal – are classified as inexplicable or accidental, thus the real number of deaths caused by wasp or bee strings could be substantially greater. Consequently hyposensitisation after severe insect sting reaction of verified allergic genesis can still be ad

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1983.tb01606.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

Phytohaemagglutinin (PHA) skin test (diameter of induration 24 h following intradermal injection of 1.0 (μg purified PHA) was carried out on 23 patients with exacerbated atopic asthma and 28 patients with exacerbated non‐atopic asthma. Preselected adult patients had either not previously been treated with systemic corticosteroids or steroid therapy had been suspended for at least 3 months. Nearly all non‐atopic asthma patients and patients with atopic asthma previously treated with corticosteroids showed increased reactions to PHA. Patients with atopic asthma not earlier treated with corticosteroids demonstrated normal responses. None of the asthmatics showed a negative PHA reaction. Administration of single depot doses of corticosteroids produced decreased reactivity to PHA in nearly all patients. These results suggest that neither atopic nor non‐atopic asthma is in itself associated with impaired PHA skin reactivity but that changes in this reactivity are largely due to the corticosteroid therapy administered to these patients. In relation to PHA reactivity certain effects of this therapy may persist for as long as 3 months after its ces

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1983.tb01607.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

In this study the maximal mid‐expiratory flow (MMEF) was compared with forced expiratory volume in 1sec (FEV1) by a spirometric investigation of healthy children and children with slight bronchial obstruction. We found that the reproducibility of MMEF was good in both healthy nd asthmatic children and that both methods had the same ability to detect abnormality before inhalation of a beta2‐receptor agonist had the same inhalation the discriminatory power was greater for FEV1than for MMEF and we therefore prefer FEV11in estimating bronchial obstruction in child

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1983.tb01608.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY