ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1985.tb02665.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

Ten patients with frequent attacks of non‐hereditary angioedema were treated with tranexamic acid or placebo in a double blind manner, each period lasting 3 months. During the tranexamic acid period nine patients became symptom‐free, or substantially improved, while one was unaffected (P<0.05). In four patients itching was a major accompanying complaint which was relieved in three. Diarrhoea and abdominal discomfort were more pronounced during tranexamic acid treatment (P<0.05), but only necessitated dose reduction in one patient. Four years later contact was obtained with eight of the nine responders and six were still taking tranexamic acid regularly, while in two patients the attacks were so infrequent that the drug was not taken regula

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1985.tb02666.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

Slow‐reacting substance of anaphylaxis (SRS‐A) is an important factor mediating bronchoconstriction in asthma. We developed a guinea pig model for SRS‐A‐mediated bronchoconstriction induced by antigen inhalation. Using this model, we investigated the effect of N‐(3′, 4′‐dimethoxycinnamoyl) anthranilic acid (N‐5′), a new anti‐allergic drug, on the bronchoconstriction. FPL 55712 inhibited most of the bronchoconstriction induced by antigen inhalation. N‐5′inhibited the antigen‐induced bronchoconstriction in a dose‐dependent fashion. Intraperitoneal administration of 200 mg/kg N‐5′was effective for 40 min after antigen inhalation, while the effect of 60 mg/kg lasted only 7 min. On the other hand, 200 mg/kg N‐5′showed no inhibitory effect on the bronchoconstriction caused by direct inhalation of leukotriene C4, a component of SRS‐A. These findings indicate that one of the anti‐allergic actions of N‐5′is due to in

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1985.tb02667.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

The influence of cyclosporin A (CyA) on human basophil histamine release inducedin vitroby specific antigen, anti‐IgE, calcium ionophore A23187, or concanavalin A (Con A) was studied. CyA inhibited the release induced by these four stimulators. It is suggested that the drug acts directly on the target cell, since similar effect was obtained with isolated peritoneal rat mast cells. The basophil histamine release was not changed by a non‐immunosuppressive cyclosporin deriv

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1985.tb02668.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

In order to screen for mould allergy, extracts of five common atmospheric moulds (Cladosporium, Alternaria, Penicillium, Aspergillus and Mucor) from various manufacturers were investigated in 130 patients (5–60 years old) with clinical symptoms indicating possible mould allergy. The patients were screened by skin prick test (SPT) and radioallergosorbent test (RAST). SPT seemed to be more sensitive than RAST as a diagnostic screening procedure (80% positive reactions to one or more species compared to 50%). With a partially purified, standardized preparation ofCladosporium herbarummore positive reactions were obtained than with crude extracts without evidence of any unspecific reactions. The difference between commercial and standardized extracts is most probably a result of a variation of both the biological potency of allergenic determinants and the allergenic composition. A considerable number of negative RAST reactions with standard discs were found in patients with positive skin reactions to partially purifiedCladosporium, but RAST seemed to be more sensitive than SPT with the other commercial mould extracts. Based on the screening, a very convincing tendency to IgE‐reactivity to other moulds was found in patients reacting toCladosporium, the most common cause of mould allergy. The results confirm the inadequacy of most mould extracts used in diagnostic procedures and strengthen the value of using standardized extra

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1985.tb02669.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

The production of IgE and IgG protein by human peripheral blood mononuclear cells in culture has been examined. Cells obtained from 18 grass‐sensitive donors during the grass, pollen season and From 11 atopic dermatitis patients (total serum IgE levels>960 ng/ml). spontaneously produced significant amounts of IgE but not IgG with time. Similar results were obtained using B‐cell enriched preparations from both groups. Cells from 16 non‐atopic donors had mean levels of pre‐formed IgE similar to those of grass pollen‐sensitive donors, but there was no increase in culture IgE with time, Treatment of mononuclear cells with pokeweed mitogen did not influence the production of IgE but markedly increased the amount of IgE synthesized by non‐atopic and atopic donr cells Slight, but significant in crease in culture IgE. but not IgG. were seen following a 7‐day lymphoblastoid B‐cell line, Raji, Treatment of cells with 50 HA units of inøluenza A/Hong Kong/1/68 (H3N2) virus or with 0.02% v/v (240 IU/ml) of a purified β‐interferon preparation did not alter

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1985.tb02670.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

In an attempt to study the role of lymphokines in asthma, lymphocytes from asthmatic patients were stimulatedin vitrowith skin test‐positive allergen (dust mite) or with non‐specific mitogen‐phytohaemagglutinin for 4h, then washed carefully and cultured alone for 16h. Cell‐free supernatants were subsequently collected and applied in the basophil histamine release testin vitroand in bronchial provocation test and skin prick testin vivo. Supernatant of non‐stimulated lymphocytes from asthmatic patients released significant amounts of histamine from basophils. Stimulation of lymphocytes with specific allergen or phytohamagglutinin augmented the supernatant‐induced histamine release. Lymphocyte supernatants from the majority of patients also induced bronchoconstriction and elicited skin wheal and flare reac

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1985.tb02671.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

In a group of aspirin‐sensitive asthmatics we studied skin weal and flare responses to intradermal injections of compound 48/80 and histamine during oral aspirin (ASA) provocation and after ASA “desensitisation”. During provocation (bronchospasm accompanied by naso‐ocular symptoms) the mean weal area after compound 48/80 increased to about 42.4% (P<0.05). Neither the threshold (provocative) doses of ASA nor 600 mg ASA, when given after ASA‐desensitisation, significantly influenced the weal reactions to compound 48/80 (mean changes of area were –1.8% and –16.5% respectively). Aspirin did not change flare reactions to compound 48/80 and weal and flare reactions to histamine on any of the three study occasions. Initial (pre‐aspirin) weal reactions to compound 48/80 after desensitisation to the threshold ASA doses were significantly reduced, but after desensitisation to 600 mg ASA were significantly increased as compared with the reactions before. These data suggest that ASA‐“desensitisation” may influence the skin reactivity to non‐specific mast cell degranulating stimulus in A

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1985.tb02672.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

Bronochial challenge with serotonin creatinine in phosphate buffer was performed in 20 stable asthmatics. In contrast to some earlier studies we observed no changes in FEV1or FVC 0 and 2 min after provocation with increasing conecntrations of serotonin (maximal conecntration 20 mg/ml). In the first eight patients the PC20histamine was 0.125–0.65 mg/ml, performed on a separate day. In three other asthmatics serotonin chloride 20 mg/ml did not affect lung function or produce any subjective symptoms. Serotonin can not be used to evaluate non‐specific bronchial hyperreactivity in asthmat

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1985.tb02673.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

Book reviewed in this articleBurkstein, D. A.&Strunk, R. C.(eds.): Manual of clinical problems in asthma, allergy and related disorders. Little, Brown and Company, Boston/Toronto.Lessof, M. H.(ed.): Allergy, Immunological and clinical aspects.

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1985.tb02674.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY