摘要:

Ten acute attacks were managed in nine patients with hereditary angioedema by means of the infusion of a C1 INH concentrate produced on large scale. No side effects were observed.

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1983.tb01590.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

The concentration of house‐dust mites (Dermatophagoidesspp.) was investigated for four seasons in three locations in each of 50 Danish apartments. Simultaneously the absolute humidity was recorded and the previously known correlation between mite counts and indoor humidity was confirmed. It appeared, however, that apartments which had a low absolute indoor humidity in the winter period (due to low household load of water vapour) did not contain noticeable concentrations of house‐dust mites in the summer and autumn despite the fact that the indoor absolute humidity in these apartments could be high enough to allow for a high peak‐population of mites. Because of this it is suggested that in a temperate climate avoidance measures against house‐dust mites should be supplemented at least by a drying out period in the winter, when this process is convenient to perform because of the low outdoor absolute h

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1983.tb01591.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

To evaluate the effect of preventive measures 46 patients, all allergic to house‐dust mites (Dermatophagoidesspp.), were randomly allocated to a study and a control group. According to the patients' subjective recordings of symptom score and use of medicine, compared with the control group, the study group had improved. There was, however, no improvement when comparing the objective recordings of morning and evening peak flow and use of medicine, and it is concluded that the preventive measures in this programme are not very effective for patients allergic to house‐dust mites. The reduction in indoor humidity in the study group was limited and, as a high indoor humidity is the cause of huge populations of house‐dust mites in homes, it is emphasized that future programmes of preventive measures should focus more on damp problems, particularly those related to bad housing constru

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1983.tb01592.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

Dog dander and hair (DDH) specific IgA, IgG and IgE antibodies from serum samples Of 202 asthmatic children, and in nasal secretion from 4 to 15 years were measured by enzyme‐linked immunosorbent assay. The results were compared with clinical history, and with allergy test (skin prick test, provocation test and RAST) using the same DDH extract. A blood sample for thein vitrolymphocyte stimulation test was obtained from 40 children, and a nasal secretion sample for analysis of the local DDH‐specific IgA, IgG and IgE antibody levels was collected form 35 of them. In children of dog‐keeping families, higher serum levels of DDH‐specific antibodies, especially IgE antibodies, were observed if the dog had been in the home already during the first years of the child's life. The serum levels of DDH‐specific antibodies, however, did not correlate with the degree of the present exposure to dogs. The serum levels of DDH‐specific or total IgE, or with the results of skin prick or provocation test. The serum levels of DDH‐specific IgA were highest in children who were subjectively most sensitive to dogs. Nasal levels of DDH‐specific IgE correlated positively with serum specific IgE levels. The correlation was weaker between nasal and serum titers of specific IgG, and not significant between nasal and serum IgA antibody levels, Specific IgE antibody levels were higher, while specific IgA and IgG antibody levels were lower, in nasal secretion form subjects with nasal symptoms on contact with dogs, when compared with subjects with other complaints (asthma, conjunctival or skin reactions). DDH‐specific IgG levels correlated negatively with specific IgE level in the nasal secretion from subjects with a positive provocation test result, while the correlation was positive in subjects with a negative provocation test. Thein vitrolymphocyte response to DDH did not correlate with the results of allergy test, or with the levels of DDH‐specific antibodies in serum or

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1983.tb01593.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

The proliferative response of T lymphocyte cultured with autologous non‐T lymphocyte is known as the autologous mixed lymphocyte reaction (AMLR). In AMLR. Both helper and suppressor functions are generated. In this investigation we have examined I cell proliferative responses in AMLR in 12 patients with bronchia asthma 10 patients with allergic rhinitis, and 10 patients with atopic dermatitis and compared that with simultaneously with bronchial asthma is significantly higher than that of health normals. However, AMRL response in patients with allergic rhinitis or atopic dermatitis is comparable to controls. Mechanisms for increased AMLR in patients with bronchial asthma are discusse

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1983.tb01594.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

The presence of cow's milk specific antibodies of immunoglobulin E and G4 classes were studied in 47 children with a positive clinical history of cow's milk allergy. The children were challenged with cow's milk orally. The clinical diagnosis was verified by immediate reactions in 25 patients while 22 had late reactions or were provocation test negative in spite of the clinical history. There was no relation between levels of cow's milk specific IgG4 antibodies and provocation test result, i.e. neither with immediate or late reactions. Total IgF. Was elevated above + 1 SD for age in 31 41 tested patients. Of these, 29 had immediate type reactions to cow's milk wheat flour and/or egg white, while only two of 10 children with IgE of less than +1 SD had a demonstrable allergy to any of these foods. The sensitivity was 80%. Specific IgE antibodies to cow's milk were demonstrated in 11 of 14 children with immediate reactions and in three of 15 who were provocation test negative or had only late reactions. This means a sensitivity of 79% and a specificity of 80%. At least had only late reactions. This means a sensitivity of 79% and a specificity of 80%. At least one of the four patients with specific IgE but negative provocation test result had earlier shown an immediate reaction when challenged with cow's milk indicating that the specific IgE antibodies were not truly “false” positive reactions but a consequence of previous allergy. Our results confirm an association between elevated total serum IgE and food allergy and an association between positive RAST to cow's milk and positive provocations in young children. We did not find any evidence for specific IgE‐1 antibodies playing a role in these pat

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1983.tb01595.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

Glococorticoids were previously considered not to affect the immediate allergic reaction. However, in a nasal allergen challenge, an inhibitory effect on the nasal symptoms induced at the challenge has been shown to occur in patients treated with a recently developed Glucocorticoid, budesonide, for 1 week prior to the challenge. This treatment was also found to reduce tissue histamine levels in the nasal mucosa. Mast cells in the mucosa were therefore studied with a view to finding out whether this reduction could be due to a reduction of mast cells. A double‐blind study was performed in 14 asymptomatic patients. Nasal biopsies were made before and after I week's treatment with either budesonide or placebo. The number of mast cells was counted in two Epon sections after the specimens has undergone specific staining with toluidine blue. No quantitative or qualitative morphological changes in the mast cells were found as a result of treatmen

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1983.tb01596.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

Antigen 22 (ag‐22) in hen's egg white, previously shown to be one of the major allergens in the egg white, was partially purified by combining biochemical separation techniques and quantitative immunoelectrophoretic methods. The molecular weight of ag‐22 was found to be approximately 78,000 using analytical ultracentrifugation and pI was determined to be 6, 1, which is appropriate with the values of ovotransferrin. It was concluded that ag‐22 is identical with ovotransferrin. The ability of ovotransferrin to react in the human IgE‐system was demonstratedin vivoandin vitro, by means of skin prick tests and crossed radioimmunoelectrop

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1983.tb01597.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

It is known that workers in the pharmaceutical industry, and nurses, can become sensitized and develop allergic respiratory symptoms by handling bulk laxatives containing Ispaghula powder. Fifteen individuals allergic to Ispaghula were challenged with a commercially available Ispaghula product and three other products manufactured in a way to make them less dusty. The results show that the use of products with smaller amounts of airborne particles results in a lower incidence of symptoms and thus probably reduces the potential occupational risk of sensitization to the Ispaghula allergen.

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1983.tb01598.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY