ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1995.tb01210.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1995.tb01211.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

In order to assess the association between atopy and cancer risk, a cohort of 6593 skin‐prick‐tested patients was established. Among atopic subjects, no overall increased cancer risk was found, but the incidence of both breast cancer (standardized incidence ratio (SIR) 2.50, 95% CI 1.01–5.16) and malignant lymphomas (SIR 4.40, 95% CI 1.20–11.3) was significantly enhanced. Atopic subjects with asthma showed a decreased overall cancer risk (SIR 0.73, 95%, CI 0.27–1.60), as compared with the other asthmatic subjects (SIR 1.46, 95% CI 1.03–2.04). The cancer risk for subjects with rhinitis was near unity (SIR 1.11), irrespective of whether the subjects were atopic or not. An almost significant risk increase for cancer was observed among subjects with urticaria (SIR 1.70, 95% CI 0.99–2.80). Our results support neither the original hypothesis of an overall cancer protective effect of atopy, nor that of an opposite effect; rather, they strengthen the view that the association between atopic diseases and canc

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1995.tb01212.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

Serum IgA and IgE levels were studied in the postnatal period in 21 infants having a paternal heredity of atopic disease. Three different sampling techniques were used, aspirated cord blood (CB), gravity‐collected cord blood, and capillary collected blood at 4–5 days of age. Significant differences among the three sampling techniques were recorded for IgA (P<0.01), but not for IgE. The IgA levels decreased from birth to 4–5 days of age in 90% (19/21) of the infants (P<0.01). The corresponding decrease in IgE levels was 20%. This postnatal difference in the frequency of decreasing/increasing IgA and IgE levels was significant (P<0.05). An analysis of CB IgA to detect maternal contamination of CB was found to be of questionable value, since only 50% (2/4) of the cases with an elevated CB‐IgA level could be considered contaminated. The results of this study further emphasize that aspiration of CB and capillary collection of blood at 4–5 days of age are the best sampling techniques to avoid contamination. The general finding that paternal heredity had no significant influence on infant IgE contrasts with the strong influence of maternal heredity. Further studies will show whether the explanation lies in genetic or transplacental factors, or in both kinds o

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1995.tb01213.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

Although bronchopulmonary manifestations are rare in inflammatory bowel diseases (IBD), subclinical abnormalities have been described in up to 50% of cases. The pathophysiology of these abnormalities remains unknown. However, a latent inflammation of the bronchial mucosa secondary to the inflammation of the intestinal mucosa has been suggested. This subclinical inflammation may lead to increased bronchial responsiveness. We studied the bronchial responsiveness in 38 inflammatory bowel disease (IBD) patients, using the methacholine test. Bronchial hyperresponsiveness was defined by a PC20M<16 mg/ml. Twenty‐four healthy controls were also studied. There was no significant difference in baseline FEV1between IBD patients and controls. However, there was a significantly greater fall in FEV1in the IBD patients at the concentrations of methacholine tested. The frequency of bronchial hyperresponsiveness was significantly higher in the IBD population (45%) than in controls (17%;P<0.03). Atopy, defined by skin test, was more common in IBD patients (42%) than in controls (21%). Even when only nonatopic subjects were considered, the frequency of bronchial hyperresponsiveness was significantly higher in IBD patients (41%) than in controls (5%;P<0.02). Thus, subclinical bronchial hyperresponsiveness is common in IBD, and may be considered a further extraintestinal manifestatio

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1995.tb01214.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

Sera of atopic individuals with predominant sensitization to either tree pollen (TAs) or tree and grass pollens (TGAs) as well as of nonatopic subjects (NAs) were analyzed for IgE, IgG, and IgG4 antibodies specific for grass pollen allergens. Of 600 atopic individuals with serum IgE antibodies specific for birch pollen allergens, 54% also had serum IgE antibodies specific for grass pollen. The mean titers of IgG antibodies specific for grass pollen proteins were about 10 times higher in the sera of TGAs than those in the TAs and NAs. SDS‐PAGE immunoblotting analysis of grass pollen proteins using sera of TGAs, TAs, and NAs with respect to the binding of these proteins with IgE and IgG antibodies in these sera exhibited a similar pattern of variation. Quantitation by enzyme immunoassay of the antibody binding to a recombinant grass pollen allergen, rKBG8.3, further demonstrated that elevated IgG antibody levels in TGAs are mainly due to a broader range of specificities, and not to high specific binding to the individual protein. Statistically significant correlation was found between IgE and IgG4 antibodies specific for the Kentucky bluegrass (KBG) extract, but not for the isolated recombinant allergen. These results indicate that the grass pollens elicit a complex array of antibody specificities in both atopics and nonatopics, and that the profile of antibodies specific to the pollen extract and pure allergens differs, suggesting that single grass allergens may be inadequate for replacing grass pollen extracts for immunotherap

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1995.tb01215.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

Fixed drug eruption (FDE) caused by oxicams is very rare. There are few reports of FDE induced by piroxicam, and this explains why cross‐sensitivity among oxicams (piroxicam, tenoxicam, and droxicam) has been studied in only one patient. The patch test on residual lesions has lately been used by some authors in FDE diagnosis with variable results. We describe two cases of piroxicam‐caused FDE and demonstrate cross‐sensitivity among piroxicam, tenoxicam, and droxicam in both of them. One patient had residual lesions and the patch test was useful for diagnosis and cross‐sensitization studies. The second patient had no residual lesions, and the patch test was negative on normal but previously affected skin; therefore, the study was performed by single‐blind controlled oral

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1995.tb01216.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

We observed two cases of maculopapular eruption occurring 12–72 h after the administration of aminocaproic acid (ACA). Patch tests performed with ACA were positive. Clinical and allergologic patterns suggest the type IV mechanism of hypersensitivity. We present what we believe are the first two cases described of hypersensitivity to this dru

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1995.tb01217.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

Human seminal plasma anaphylaxis (HSPA) is rare but may be life‐threatening. The antigen or antigens involved in these reactions reside in a glycoprotein fraction of human seminal plasma (HSP). We report a woman who experienced HSPA. Literature on the subject is reviewe

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1995.tb01218.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

We aimed to determine whether the nasal provocation test (NPT) with allergen could be used as a diagnostic test in asthmatic children with or without allergic rhinitis, and whether it had any effects on pulmonary function tests and arterial oxygen saturation (SaO2) values. Therefore, 25 asthmatic outpatients sensitive toDermatophagoides pteronyssinus(Dp), aged 6–17 years, 12 having allergic rhinitis, and 10 nonatopic children as a control group were challenged intranasally with solution containing Dp extract by administration of a total dose of 800–1000 AU to both nasal cavities. Before the test and 10 min and 20 min after the administration of the allergen intranasally, the nasal expiratory peak flow (NEPF), pulmonary function tests, and SaO2were measured. In the NPT, a decrease of 20% or more in NEPF and occurrence of nasal symptoms were considered to be positive. NPT was positive in all the asthmatic patients with or without allergic rhinitis, while all the children in the control group had a negative test. Compared to values prior to the test, values of FEV1, (forced expiratory volume in 1 s) and SaO2showed no statistically significant decrease, and no clinically significant asthmatic reaction was observed in any of the groups. Our study suggests that in asthmatic children with or without allergic rhinitis, the NPT with allergen is a simple, safe, and useful diagnostic t

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1995.tb01219.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY