ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1989.tb02230.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

To examine the influence of the histamine chloride challenge test on the bronchoalveolar lavage cell population, lavage fluid from 15 subjects was collected 24 h after the histamine test, and was compared with the lavage fluid from a reference group of 25 subjects. Inhaled histamine is commonly used to quantitate non‐specific bronchial responsiveness. Increase in airway responsiveness after exposure to ozone or allergen is associated with airway inflammation. Bronchoalveolar lavage, has therefore become a valuable tool in the study of bronchoalveolar cells and mediators in subjects with asthma and bronchial hyperresponsiveness. The total cell number and differential cell counts in bronchoalveolar lavage fluid 24 h after inhalation challenge test with histamine‐chloride were studied. There was a significant increase in lymphocytes, mast cells and neutrophils after histamine test. The conclusion was that inhaled histamine‐chloride can induce an inflammatory cell response in the lung. Thus the histamine‐chloride test should not be performed before bronchoalveolar

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1989.tb02231.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

The helper/suppressor T cell ratio, as defined by monoclonal antibodies, was significantly higher in hay fever sufferers compared with controls (P<0.05), but only during or shortly after the pollen season. This was due to a reduction in the suppressor subset, which returned to control values in the winter. There was no significant difference in the non‐specific concanavalin A‐induced suppressor cell function compared with controls. The mean summer value was significantly lower than the winter value (P<0.05), but we cannot be sure that this was not the result of changes in laboratory conditions. No relationship was found between T cell subsets or suppressor cell function and total or specific IgE levels, or between T cell subsets and suppressor cell function. Our findings suggest that in hay fever, reduction in suppressor cell numbers and function is a secondary phenome

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1989.tb02232.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

The efficacy of hyposensitization with standardised extract ofDermatophagoides pteronyssinus (D. pteronyssinus)conjugated to alginate and containing known amounts of antigen P1 (Conjuvac®) was tested in a double blind, placebo controlled, multi‐centre study in 66 adult patients with perennial rhinitis. Patients received 11 weekly injections of increasing concentrations of Conjuvac containing from 56 × 101to 448 × 103IUD. pteronyssinusor placebo injections of the alginate diluent to some of which 5 μg of histamine has been randomly added This was followed by 15 monthly injections of Conjuvac or placebo. The severity of nasal blockage, sneezing and rhinorrhoea was recorded twice daily in a diary and visual analogue assessments (VAS) made at each clinic visit. Nasal provocation testing (NPT) was performed with increasing concentrations of the same extract ofD. pteronyssinusas used in the hyposensitization injections, and changes in nasal airways resistance measured by passive anterior rhinomanometry. VAS was recorded and NPT was performed on entry to the study and after the fifth, ninth and final monthly injection. Conjuvac injections were well tolerated. Large local reactions (>5 cm) occurred within 30 min in only 1% of patients but later in 23%. No systemic reactions or anaphylaxis occurred within 30 min of injections, but urticaria or worsening of asthma and rhinitis was reported later in 3% of patients. A significant improvement in nasal obstruction occurred in the Conjuvac compared to the placebo treated group (P<0.01) and there was significant increase in the percentage of patients able to tolerate provocation with the highest concentrations ofD. pteronyssinusextract after nine and 15 maintenance injections of Conjuvac compared to the placebo (P0.02,P<0.001). Patient use of additional therapy decreased sooner in the Conjuvac treated group but was minimal in both groups after 5 months of the

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1989.tb02233.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

The occurrence of allergy was studied in 224 patients with verified acute maxillary sinusitis by means of an allergy questionnaire, skin testing, and nasal smears. Allergy was found in 56 patients (25%), In addition, allergy was considered probable in 14 patients (6.5%). The corresponding percentages in the control group were 16.5 and 3, respectively. The difference is statistically significantP<0.05). However, the frequency of allergy is lower in the present series than in those previously reported on chronic sinusitis. There were no differences between allergic and non‐allergic patients in the number of prior acute sinusitis episodes or of previously performed sinus irrigations. Bacteriological and radiological findings did not differ significantly between the group

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1989.tb02234.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

Circulating immune complexes (CIC) were determined from dog‐allergic asthmatic children (n= 35) receiving immunotherapy with dog dander and hair extract. The results from CIC are expressed in SDU (standard deviation units) and presented as follows: pretreatment results (n= 20), rush results (n= 11), mid‐schedule results (n= 20), maintenance results (n= 15) and the results of the placebo‐treated group (n= 12). The results of the placebo‐treated group (n= 12) and those of the untreated atopic (n= 12) and non‐atopic (n= 14) were controls. CIC levels were analysed by means of KgB‐ELISA (conglutinin binding enzyme linked immunosorbent assay), C1qB‐ELISA (C1q‐binding enzyme linked immunososrbent assay), RFb‐ELISA (rheumatoid factor binding enzyme linked immunosorbent assay) and by PIPA (platelet 125J‐labelled staphylococcal protein‐A test). The CIC level determined by KgB‐ELISA in dog‐allergic asthmatic children was higher than that of the atopic controls (P<0.05) already before the onset of the hyposensitization. During conventional hyposensitization with dog dander and hair the CIC level remained the same as before treatment. On day 5 of rush hyposensitization the mean level of CIC showed no increase when compared with the pretreatment values. A statistically significant correlation (P<0.01) was observed between the dog dander and hair‐specific IgG antibodies and the CIC level measured by KgB‐ELISA during the maintenance period of conventional immunotherapy. The samples of sera to measure this correlation were collected before the injection of allergen and after 2 weeks of injection during maintenance treatment. In general, the treatment was well tolerated in all groups. As expected, immediate reactions after injections were seen during rush hyposensitization. No long‐lasting or late reactions were observed, nor any correlation between adverse reactions and the level of CIC. Mild local reactions were seen during conventional depot hyposensitization. No clinical adverse effects were observed that could have been associated with occasio

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1989.tb02235.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

Guinea pigs inbred for their ability to develop respiratory anaphylaxis to experimental antigens have been used for comparison of different forms of immunotherapy (IT). Passive, active and combined (immune complexes between antigen and specific IgG) IT were compared with placebo. The bronchial reactivity of the animals to the antigen was monitored regularly before, during (35 weeks) and after IT (20 weeks). Animals treated with passive IT did not improve clinically. Active and combined IT abolished most symptoms within 7 weeks of treatment. During the post‐treatment period, animals from both groups surprisingly recovered their original sensitivity to inhalation of the antige

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1989.tb02236.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

The relation between platelet counts (PCT) and IgE was studied in cord blood from 136 European newborns. PCT was significantly lower (P= 0.0014) when cord‐IgE was superior to 1.20 IU/ml (n= 29; 245,000/μl) than when it was inferior to this value (n= 107; 284,080/μl) which resulted in a significant negative Spearman rank correlation between PCT and cord‐IgE (P= 0.002; rs=−0.25). A follow‐up by questionnaire in 97 of the newborns revealed that those newborns who had developed definite atopy within 18 months of age had significantly (P= 0.002) lower PCT at birth (n= 8; 196,000/μl) than those free of atopic symptoms (n= 61; 286,000/μl). Further newborns to atopic mothers (n= 23; 245,000/μl) had significantly (P= 0.014) lower PCT than newborns to non‐atopic mothers (n= 74; 286,000/μl). The lowest PCT was recorded when both the mother was atopic and the newborn had developed definite or probable atopy by the age of 18 months (n= 7; 175,000/μl) as compared to atopy alone in mothers (n= 16; 276,000/μl;P= 0.005), to atopy alone in infants (n= 9; 281,000/μ1;P= 0.005) and to non‐atopic infants of non‐atopic mothers (n= 65; 286,000/μl;P= 0.0007). Significantly (P= 0.03) lower PCT amongst boys (n= 49; 259,000/μl) compared with girls (n= 48; 294,000/μl) was attributed to the higher incidence of elevated cord‐IgE and infant atopy among boys. These findings were limited to PCT, since the erythrocyte count, hematocrit and hemoglobin concentration in cord blood did not significantly (P>0.10) differ in any of these groups. Paternal atopy and atopy in siblings did not influence PCT, neither did maternal smoking or drug intake (progesterone and β‐mimetics) during pregnancy. These data as a whole are compatible with a direct or indirect role for platelets and their mediators in immediate hypersensitivity reactions. We speculate that a low PCT in cord blood of newborns reflects an on‐going intra‐uterine sensitization and therefore it might be a complementary parameter to family history and cord‐IgE in predicting newbo

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1989.tb02237.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

A boy and a girl, 10 weeks and 3 years of age, respectively, were admitted to our department with low temperature, dry cough, fatigue and weight loss. In both patients pulmonary X‐rays showed diffuse, bilateral, micronodular infiltrations, and sparse signs of fibrosis. Serum IgG and blood eosinophils were abnormally high. After a stay in hospital for 3 weeks, the patients recovered slowly. However, after a few days at home, they were readmitted with the same symptoms. Family histories revealed that the children lived on farms with huge grain magazines and dryers, where moist grain and straw were stored. Massive amounts of mould spores were cultured from the residential areas, and, in addition, the male patient had an elevated titer toMicropolyspora faeniand the female patient, elevated titers toThermoactinomyces vulgaris, Micropolyspora faeni, Aspergillus fumigatusandAlternaria alternans.The patients and their families moved from the farms and, for approximately a year, have been without lung symptoms. Farmer's disease in infants and small children is extremely rare. However, the incidence may be increasing due to the tendency in latter years to decentralize grain dryers and store moist grain and straw in big magazines, often close to residential area

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1989.tb02238.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

We report on a patient with occupational asthma caused by iroko. BPT induced an early and late response with a long recovery period, and absence of inhibition on pretreatment with cromoglycate and beclomethasone. Three months after leaving his job, the patient was symptom‐free, but non‐specific bronchial hyperreactivity was still demonstra

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1989.tb02239.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY