ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1979.tb01561.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1979.tb01562.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Crossed immunoelectrophoresis (CIE) of a commercial house‐dust extract revealed 43 immunoprecipitates.Rocket immunoelectrophoresis with 106 different allergen extracts from animal hair and dander, feathers, fungi, pollen, foodstuffs, textiles and house‐dust mites showed the presence of precipitating antibodies in the rabbit anti‐house‐dust serum against antigens from 34 of the extracts.Crossed immunoelectrophoresis with the addition of antigen, and crossed line immunoelectrophoresis (CLIE) with these 34 allergen extracts, as well as crossed immunoelectrophoresis with intermediate gel containing rabbit antibodies against nine human serum proteins, allowed the identification of 14 antigens in the house‐dust extract. These antigens were shown to originate from house‐dust mites, hair and dander from various animals, fungi, feathers, human hair and dander, and human ser

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1979.tb01563.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Levels of airway's hyperreactivity, as indexed by methacholine and histamine thresholds, were determined for hospitalized asthmatic patients using the serial concentration, constant‐breath method. Airways hyperreactivity was categorized into tow and high based on a split of the sample of subjects tested. These categories were unrelated to pulmonary function measurements obtained throughout hospitalization. Patients having high airways hyperreactivity to histamine or methacholine were admitted for intensive inpatient care at a younger age, had an earlier age of onset, and had asthma of longer duration than patients having low airways hyperreactivity. These latter results suggested that relatively greater airways hyperreactivity is more likely to be associated with early onset of the illnes

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1979.tb01564.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Twenty‐two adults with extrinsic bronchial asthma were examined with 26 different allergens from five groups: house dust + mite (30 BP), animal dandruff (30 BP), pollen (12 BP), mould fungi (11 BP), and feather + cotton (10 BP). The same allergen batch was used for each allergen extract in all analyses.Based on the results of the single analyses: case history (CH), intracutaneous test (ST), RAST, histamine release from basophil leucocytes (HR), and the results of the analysis combinations and the “true diagnosis” bronchial provocation (BP), the sensitivity and specificity (SE and SP) were calculated and shown graphically. An evaluation of the diagnostic reliability of the single analyses and analysis combinations was then possible.Generally, HR was the best individual analysis with very few false positive values and false negative values, followed by RAST, ST, and CH. None of them was able to predict allergy for feather + cotton. Otherwise, BP was positive when HR and RAST reached scores 2 and 3 with the exception of RAST for animal dandruff. As regards ST, we had to reach score 3 in order to predict positive BP. CH would only provide the diagnosis with a maximum score in the pollen group. BP was positive in any analysis combination resulting in score 6 or more. ST appeared to be the most sensitive of the individual analyses. Alt the patients with ST score 0 showed negative BP for all allergen groups, whereas a corresponding sensitivity for HR score 0 was only achieved with animal dandruff, and for RAST score 0 for pollen only.In spite of the new analyses, BP is in many cases necessary if a definite diagnosis is req

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1979.tb01565.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

The influence of artificially generated atmospheric ions is studied in 15 patients with bronchial asthma. A slight but significant (at 5% level) improvement in the lung function was demonstrated in nine patients during positive as well as negative ion exposure, but the patients’ subjective votings of the air quality did not show any changes due to ion exposure. No change in the histamine threshold of the airways in six patients with bronchial asthma was demonstrated during exposure to ions. Further controlled studies with electro‐aerosols are nee

ISSN:0105-4538    

DOI:10.1111/j.1398-9995.1979.tb01566.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY