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1. |
Preface |
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Journal of Electron Microscopy Technique,
Volume 14,
Issue 2,
1990,
Page 89-89
Douglas L. Schmucker,
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ISSN:0741-0581
DOI:10.1002/jemt.1060140202
出版商:Wiley Subscription Services, Inc., A Wiley Company
年代:1990
数据来源: WILEY
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2. |
Foreword |
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Journal of Electron Microscopy Technique,
Volume 14,
Issue 2,
1990,
Page 90-91
Hans Popper,
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PDF (157KB)
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ISSN:0741-0581
DOI:10.1002/jemt.1060140203
出版商:Wiley Subscription Services, Inc., A Wiley Company
年代:1990
数据来源: WILEY
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3. |
Fine structure and function of hepatocytes during development |
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Journal of Electron Microscopy Technique,
Volume 14,
Issue 2,
1990,
Page 92-105
Shinsuke Kanamura,
Kazuo Kanai,
Jun Watanabe,
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摘要:
AbstractThis paper reviews the fine structure and function of hepatocytes during fetal and postnatal development. Bile canaliculi develop to a mature appearance during perinatal and early postnatal periods, while bile secretory function is immature at birth and develops during the postnatal period. The rough endoplasmic reticulum is prominent and remains unchanged in amount during development, and the Golgi complex is large from early stages of fetal life. The smooth endoplasmic reticulum (SER) appears shortly before birth and increases in quantity to the adult level after birth. In mouse hepatocytes, Sv (area per unit cytoplasmic volume) of SER increases in perivenular cells between 1 and 10 days of age, although it remains low in periportal cells. Similarly, Sv of total ER increases in both periportal and perivenular cells between 1 and 5 days of age and then becomes greater in perivenular than periportal cells. This suggests that the postnatal increase in the drug‐metabolizing capacity occurs predominantly in perivenular hepatocytes. SER proliferates after phenobarbital (PB) administration in both perivenular and periportal cells in 3‐, 5‐, and 10‐day‐old mice, and predominantly in perivenular cells in 20‐day‐old and adult mice. Thus the conspicuous proliferation of SER in perivenular hepatocytes after PB administration, characteristic of adult liver, becomes manifest during postnatal development. In mouse hepatocytes, Vv (volume per unit cytoplasmic volume) of mitochondrial matrix and peroxisomes and Sv of mitochondrial inner membrane and cristae increase in both periportal and perivenular cells between birth and 10 days of age. Then, Vv of mitochondrial matrix remains unchanged in periportal cells but decreases in perivenular cells. In general, the process of postnatal hepatocyte differentiation appears to include several phases of development; cell organelles develop during the early postnatal period, subsequently the cells undergo both functional and structural heterogeneity, and the late postnatal period after weaning is the time for a marked increase
ISSN:0741-0581
DOI:10.1002/jemt.1060140204
出版商:Wiley Subscription Services, Inc., A Wiley Company
年代:1990
数据来源: WILEY
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4. |
Hepatocyte fine structure during maturation and senescence |
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Journal of Electron Microscopy Technique,
Volume 14,
Issue 2,
1990,
Page 106-125
Douglas L. Schmucker,
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摘要:
AbstractAging is accompanied by a myriad of changes in cell structure, function, and composition. The fact that much of the information concerning age‐related alterations in cellular morphology is qualitative precludes meaningful correlations with biochemical changes in order to enhance data interpretation. The mammalian liver has been subjected to both qualitative and quantitative evaluations of hepatocyte structure as a function of aging, i.e., development, maturation, and senescence. Although these data are characterized by considerable variability and, in some instances, blatant contradictions, there exists sufficient agreement in several parameters to permit a consensus in the inbred rat model. Certainly the volume of individual hepatocytes increases with age, and many of the organelle compartments reflect this change. While old rats exhibit a high incidence of polyploidy, there is no definitive evidence to demonstrate a concomitant increase in the binuclear hepatocyte index. Several specific hepatocellular organelles undergo changes in their relative volume or surface area that appear to correlate with functional alterations. The volume density of the lysosomal compartment enlarges significantly during senescence and is accompanied by increased activities of several constituent hydrolases. The hepatic concentration of smooth‐surfaced endoplasmic reticulum declines markedly with aging, as does the yield of liver microsomes and the activities of several microsomal enzymes, e.g., mono‐oxygenases and glucose‐6‐phosphatase. However, the responses of the majority of hepatocyte organelles to aging is varied and inconsistent based on the limited data currently
ISSN:0741-0581
DOI:10.1002/jemt.1060140205
出版商:Wiley Subscription Services, Inc., A Wiley Company
年代:1990
数据来源: WILEY
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5. |
Heterogeneity of glycogen distribution in hepatocytes |
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Journal of Electron Microscopy Technique,
Volume 14,
Issue 2,
1990,
Page 126-139
Robert R. Cardell,
Emma Lou Cardell,
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ISSN:0741-0581
DOI:10.1002/jemt.1060140206
出版商:Wiley Subscription Services, Inc., A Wiley Company
年代:1990
数据来源: WILEY
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6. |
Hepatocellular processing of endocytosed proteins |
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Journal of Electron Microscopy Technique,
Volume 14,
Issue 2,
1990,
Page 140-151
Susan Jo Burwen,
Albert L. Jones,
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ISSN:0741-0581
DOI:10.1002/jemt.1060140207
出版商:Wiley Subscription Services, Inc., A Wiley Company
年代:1990
数据来源: WILEY
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7. |
Morphology, ultrastructure, and function of hepatocytes during liver drug metabolism |
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Journal of Electron Microscopy Technique,
Volume 14,
Issue 2,
1990,
Page 152-174
C. F. A. Van Bezooijen,
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ISSN:0741-0581
DOI:10.1002/jemt.1060140208
出版商:Wiley Subscription Services, Inc., A Wiley Company
年代:1990
数据来源: WILEY
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8. |
Rapid Communication. A Micro‐sample critical point drying device for small SEM and TEM specimens |
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Journal of Electron Microscopy Technique,
Volume 14,
Issue 2,
1990,
Page 175-176
Gregory W. Strout,
Scott D. Russell,
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ISSN:0741-0581
DOI:10.1002/jemt.1060140209
出版商:Wiley Subscription Services, Inc., A Wiley Company
年代:1990
数据来源: WILEY
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9. |
A high resolution SE‐I SEM assessment of diimidoester fixed chimpanzee sperm |
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Journal of Electron Microscopy Technique,
Volume 14,
Issue 2,
1990,
Page 177-178
Robert P. Apkarian,
Leona G. Young,
Kenneth G. Gould,
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PDF (236KB)
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ISSN:0741-0581
DOI:10.1002/jemt.1060140210
出版商:Wiley Subscription Services, Inc., A Wiley Company
年代:1990
数据来源: WILEY
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10. |
Masthead |
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Journal of Electron Microscopy Technique,
Volume 14,
Issue 2,
1990,
Page -
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PDF (131KB)
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ISSN:0741-0581
DOI:10.1002/jemt.1060140201
出版商:Wiley Subscription Services, Inc., A Wiley Company
年代:1990
数据来源: WILEY
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