摘要:

AbstractAdvances in newer techniques for high sensitivity sequence analysis of polypeptides coupled with improvements in solid phase synthesis procedures have led to systematic analyses of structure‐activity relations in parathyroid hormone. Twenty‐five amino acids at the amino terminus of the 84 amino acid peptide suffice for biological expression of hormonal actions on kidney and bonein vivoandin vi

ISSN:0021-2148    

DOI:10.1002/ijch.197400052

出版商:WILEY‐VCH Verlag    

年代:1974

数据来源: WILEY

摘要:

AbstractAnalysis of the structure‐function relationships of ACTH and the melanotropins of the pituitary gland indicates that a tetrapeptide segment common to the structures of these hormones is involved in eliciting such diverse biological actions as stimulation of adrenal steroidogenesis, lipolysis and melanin dispersion. The structural features of the hormones around the common peptide segment serve to distinguish between receptors in the different target tissues and ensure relative specificity of function of such closely related molecules as ACTH and α‐MSH. Although the mammalian adrenal cortical cell and the amphibian melanocyte appear to be stimulated by the same peptide segment, it can be inferred that there are significant differences in the structural features of the receptors in the two cell types even in the region of interaction with the peptide segment. The evolutionary interrelationships of these hormones as well as their specific receptors are also discu

ISSN:0021-2148    

DOI:10.1002/ijch.197400053

出版商:WILEY‐VCH Verlag    

年代:1974

数据来源: WILEY

摘要:

AbstractThe periodic collagen‐like polytripeptide (Pro‐Gly‐Pro)nis immunogenic in several species of animals. Antibodies to this polymer are specific to the unique collagen‐like conformation of the immunogen. There is an immunological cross‐reactivity between (Pro‐Gly‐Pro)nand natural collagens in several systems, and it is possible to induce an autoimmune response to collagen by means of the synthetic polymer. The ordered polymer (Pro‐Gly‐Pro)nas well as collagen are thymus‐independent antigens, whereas the random polymer (Pro66, Gly34)nand gelatin a

ISSN:0021-2148    

DOI:10.1002/ijch.197400054

出版商:WILEY‐VCH Verlag    

年代:1974

数据来源: WILEY

摘要:

AbstractSnake venoms (bungarotoxin, cobratoxin), frog poisons (histrionicotoxin, batrachotoxin and atelopidtoxin), and fish toxins (tetrodotoxin, saxitoxin) permit selective inhibition of receptors and ion transport mechanisms in electrogenic membranes. Selective ion binding mechanisms are exemplified by the sodium and lithium complexes of antamanide, the naturally occurring cyclic decapeptide from the mushroomAmanita phalloides.

ISSN:0021-2148    

DOI:10.1002/ijch.197400055

出版商:WILEY‐VCH Verlag    

年代:1974

数据来源: WILEY

ISSN:0021-2148    

DOI:10.1002/ijch.197400001

出版商:WILEY‐VCH Verlag    

年代:1974

数据来源: WILEY