摘要:

AbstractReaction of a 6‐methylmercaptopurine with methyl iodide in an aprotic solvent gives only a single methylation product. Both the 7‐ and the 9‐methyl derivatives are alkylated at N‐3. 3‐Methyl‐6‐methylmetcaptopurine is attacked at N‐7, while the 1‐methyl isomer is substituted at position 9. The course of the latter reaction depends markedly on the reaction conditions, as in the presence of an alkali carbonate alkylation takes place at N‐7. The mechanism of these methyl

ISSN:0021-2148    

DOI:10.1002/ijch.196500044

出版商:WILEY‐VCH Verlag    

年代:1965

数据来源: WILEY

摘要:

AbstractA Friedel‐Crafts reaction of 2,8‐dimethoxynaphthalene with β‐methyltricarballylic acid anhydride (I) gave the ketoacid (IId), which upon catalytic hydrogenation and cyclization with hydrogen fluoride afforded the tricyclic ketone (V). Addition of methyl acrylate yielded the tetracyclic ester (VI), which was dehydrated and then decarboxylated at carbon 15. The reactions could be controlled to produce either the 17α‐ or the 17β epimers (IX) and (X). Their hydrogenation furnished the 14β, 17α‐ and 14α, 17β isomers (XII) and (XIb), respectively. The latter was transformed into the 17β‐acet

ISSN:0021-2148    

DOI:10.1002/ijch.196500045

出版商:WILEY‐VCH Verlag    

年代:1965

数据来源: WILEY

摘要:

AbstractAn easy synthesis of 6‐methoxy equilenin derivatives is described starting with 7α‐bromo‐6‐ketoestradiol 17‐acetate (Va). The resulting 6‐hydroxyequilenin dimethyl ether (VIIIa) was transformed into 17β‐acetamido‐3,6‐dimethoxy‐1,3,5(10), 6,8‐estrapentaene (IXd), the racemic form (XIIId) of which was made from the totally synthetic compounds (Xa) and (XIa), Also the D‐antipode (XXI) of 3,6‐dimethoxy‐176 ‐acetyl‐1,3,5(10), 6,8‐estrapentaene was synthesized from (VIIIa) and compared with its racemic form (XIa). Treatment of the estrapentaene (VIb) with sodium and isopropanol afforded the ketone (XVIb) which was

ISSN:0021-2148    

DOI:10.1002/ijch.196500046

出版商:WILEY‐VCH Verlag    

年代:1965

数据来源: WILEY

ISSN:0021-2148    

DOI:10.1002/ijch.196500047

出版商:WILEY‐VCH Verlag    

年代:1965

数据来源: WILEY

ISSN:0021-2148    

DOI:10.1002/ijch.196500048

出版商:WILEY‐VCH Verlag    

年代:1965

数据来源: WILEY

ISSN:0021-2148    

DOI:10.1002/ijch.196500049

出版商:WILEY‐VCH Verlag    

年代:1965

数据来源: WILEY

ISSN:0021-2148    

DOI:10.1002/ijch.196500043

出版商:WILEY‐VCH Verlag    

年代:1965

数据来源: WILEY