摘要:

AbstractConversion of 2‐amino‐6‐methyl(II), 2‐methylamino‐6,9‐dimethyl (III) and 6‐methyl‐8‐trifluoromethylpurine(IV) into their 6‐trichloromethyl analogs was achieved with sulfuryl chloride in trifluoroa

ISSN:0021-2148    

DOI:10.1002/ijch.196400002

出版商:WILEY‐VCH Verlag    

年代:1964

数据来源: WILEY

摘要:

AbstractThe potent tryponocidal drug, ethidium bromide was found to exert an inhibitory effect on the synthesis of ribonucleotides from preformed purines in rabbit red blood cells. The inhibition was much more pronounced with reticulocytes than with mature erythrocytes. The same compound showed little if any effect on the de novo synthesis of purine nucleotides in reticulocytes.The major biochemical lesion induced by ethidium bromide was reflected in a decline of the intracellular ATP content. The ATP decay was attributable to the deleterious action of the drug on the mitochondrial respiration and oxidative phosphorylation. The preferential blockage of the nucleotide formation from exogenously supplied purines appears to be determined by the high demand of this system for ATP supply owing to its vigorous activity contrasting with the slow rate of the de novo biosynthetic pathway.Our data do not support the hypothesis of Kandaswamy and Henderson (Biochim. Biophys. Acta, 61: 86, 1962) postulating the separate existence and metabolism of two biosynthetically distinct pools of purine ribonucleotides.

ISSN:0021-2148    

DOI:10.1002/ijch.196400003

出版商:WILEY‐VCH Verlag    

年代:1964

数据来源: WILEY

摘要:

AbstractThe reduction of Ag+in aqueous solution by atomic hydrogen produced in an electrodeless high frequency discharge was studied. The apparent rate constant of the reduction of Ag+by hydrogen atoms k= 5.105litre·mole−1·sec−1. A reaction mechanism was derived which correlates the present results with those of Littman, Carr and

ISSN:0021-2148    

DOI:10.1002/ijch.196400004

出版商:WILEY‐VCH Verlag    

年代:1964

数据来源: WILEY

摘要:

AbstractSmall amounts of lithium were separated from large amounts of sodium, potassium, calcium and magnesium ions. The separation was performed by a cation exchange chromatographic method. Amberlite IR‐120 was used as cation exchanger and a mixture of methanol (9 volumes)‐hydrochloric acid (1 volume) was employed as eluent. The separation was quantitative, lithium was eluted first and the effluents containing lithium were free from other cations. In the effluent, lithium was determined by a flame photometric proced

ISSN:0021-2148    

DOI:10.1002/ijch.196400005

出版商:WILEY‐VCH Verlag    

年代:1964

数据来源: WILEY

摘要:

Abstract4‐Fluoroindole(VIII) has been prepared by a five‐step synthesis from 2‐fluoro‐6‐nitrotoluene (III). (VIII) has been converted into a number of N,N‐dialkylated 4‐fluo

ISSN:0021-2148    

DOI:10.1002/ijch.196400006

出版商:WILEY‐VCH Verlag    

年代:1964

数据来源: WILEY

ISSN:0021-2148    

DOI:10.1002/ijch.196400007

出版商:WILEY‐VCH Verlag    

年代:1964

数据来源: WILEY

ISSN:0021-2148    

DOI:10.1002/ijch.196400008

出版商:WILEY‐VCH Verlag    

年代:1964

数据来源: WILEY

ISSN:0021-2148    

DOI:10.1002/ijch.196400009

出版商:WILEY‐VCH Verlag    

年代:1964

数据来源: WILEY

ISSN:0021-2148    

DOI:10.1002/ijch.196400010

出版商:WILEY‐VCH Verlag    

年代:1964

数据来源: WILEY

ISSN:0021-2148    

DOI:10.1002/ijch.196400001

出版商:WILEY‐VCH Verlag    

年代:1964

数据来源: WILEY