ISSN:0021-2148    

DOI:10.1002/ijch.196800072

出版商:WILEY‐VCH Verlag    

年代:1968

数据来源: WILEY

摘要:

AbstractChemical conversions of 6‐(3‐methyl‐2‐butenylamino)purine, 2iP, and 6‐(3‐methyl‐3‐butenylamino)purine, 3iP, to common products have been effected. A number of compounds related to these isomers and their ribosides have been synthesized, including 6‐(3‐hydroxy‐3‐methylbutylamino)‐9‐β‐D‐ribofuranosylpurine, 6‐(3‐chloro‐3‐methylbutylamino)purine, 6‐(3, 4‐dihydroxy‐3‐methylbutylamino) purine, and 6‐(3,4‐dihydroxy‐3‐methylbutylamino)‐9‐β‐D‐ribofuranosylpurine, and the cytokinin activities have been compared in the tobacco bioassay. The effect of 4‐hydroxyl substitution on the side chain has been noted. Diagnostic fragm

ISSN:0021-2148    

DOI:10.1002/ijch.196800073

出版商:WILEY‐VCH Verlag    

年代:1968

数据来源: WILEY

摘要:

AbstractThe acylation of N‐monosubstituted benzimidazoles with various acid chlorides in ethyl acetate — aqueous bicarbonate mixture was investigated. The reaction, which leads to the fission of the imidazole ring, was found to be strongly dependent on the substitution on both the benzimidazole and the acid chloride used. Electron withdrawing groups in the benzimidazoles were found to facilitate the reaction. Carbobenzoxy chloride and ort ho substituted benzoyl chloride gave the highest yields of the fission products. The carbobenzoxylation and benzoylation of unsubstituted, 2‐monosubstituted and 1,2‐disubstituted benzimidazoles were also inves

ISSN:0021-2148    

DOI:10.1002/ijch.196800074

出版商:WILEY‐VCH Verlag    

年代:1968

数据来源: WILEY

摘要:

AbstractCis and trans forms of 2‐amino‐3(4, 5, and 6)‐methoxybenzaldoximes were separated chromatographically and distinguished by their spectra. The trans‐isomers, with triethyl orthoformate, gave 5(6, 7, or 8)‐methoxyquinazoline‐3‐oxide whereas appropriate cis‐isomers gave 7‐ or 9‐methoxy‐3,1,4‐benzoxadiazepine. The structures of the bicyclic products were confirme

ISSN:0021-2148    

DOI:10.1002/ijch.196800075

出版商:WILEY‐VCH Verlag    

年代:1968

数据来源: WILEY

摘要:

AbstractIn 7‐benzyl‐6‐mercaptopurine the benzylic methylene resonates at a lower magnetic field compared to other N‐benzyl groups and can be easily characterized. This deshielding effect is attributed to the magnetic anisotropy of the carbon6‐sulphur bond. In trifluoroacetic acid a slow proton‐exchange is observed for 1‐and 3‐benzyl‐6‐mercaptopurines but not f

ISSN:0021-2148    

DOI:10.1002/ijch.196800076

出版商:WILEY‐VCH Verlag    

年代:1968

数据来源: WILEY

摘要:

AbstractThe synthesis of 1,2‐disubstituted perhydropyridazine‐3,6‐diones in high yield is described. The reaction of succinic anhydride and 1,2‐dialkylhydrazines leads to N,N′‐dialkyl‐3‐carboxypropionhydrazides which are converted to 1,2‐dialkylperhydropyridazine‐3,6‐diones in refluxing xylene or polyphosphoric acid. The reaction of 1,2‐diarylhydrazines with 3‐carbomethoxypropionyl chloride and hydrolysis of the resulting N,N′‐diaryl‐3‐carbomethoxypropionhydrazides yields N,N′‐diaryl‐3‐carboxypropionhydrazides. Cyclization of these acid‐hydrazides in thionyl chloride at low temperature affords the corresponding 1, 2‐diarylperhydropyridazine‐3,6‐diones. The alkylation of 1,2‐dipropyl‐perhydropyridazine‐3,6‐dione in various base‐s

ISSN:0021-2148    

DOI:10.1002/ijch.196800077

出版商:WILEY‐VCH Verlag    

年代:1968

数据来源: WILEY

摘要:

AbstractThe synthesis of various 6‐mono‐ and 5,6 dihalogeno‐uracils is described. It is shown by ultraviolet absorption spectral comparisons in aqueous solutions that the neutral species of all synthesized compounds exist in the dilactam form. The monoanions are formed by loss of a proton from N‐1. pKavalues and ultraviolet absorption spectra are reported and the influence of the different halogen substituents are on these properties di

ISSN:0021-2148    

DOI:10.1002/ijch.196800078

出版商:WILEY‐VCH Verlag    

年代:1968

数据来源: WILEY

摘要:

AbstractThe polarographic oxidation of 2, 5‐diaminopyrimidine (IV) and 4,5‐diaminopyrimidine (V) at the rotating Pt microelectrode in aqueous buffered solutions was studied. The effects of varying concentrations, temperature, pH, buffer concentration, rate of rotation of electrode and rate of scanning of potential were determined. The limiting currents are diffusion controlled and proportional to concentration up to 1 × 10−3M for (IV) and 2 × 10−4M for (V). The overall reaction is irreversible and probably involves two electrons per molecule to give an unstable product with a quinonimine structure. The dependence of E½ on pH in the anodic polarography of twelve more polyamino‐ and aminohydroxy‐pyrimidines was determined. Hückel type MO calculations were carried out for the pyrimidines and the energies calculated for the highest occupied MOs were correlated

ISSN:0021-2148    

DOI:10.1002/ijch.196800079

出版商:WILEY‐VCH Verlag    

年代:1968

数据来源: WILEY

摘要:

AbstractThe synthesis of a number of antibacterial 3,5‐disubstituted pyrazoles and isoxazoles starting from beta‐diketones and a hydrazine or hydroxylamine respectively is described. A furyl or 5‐nitrofuryl group was always one of the substituents. The nitration of the furan ring could be performed at any

ISSN:0021-2148    

DOI:10.1002/ijch.196800080

出版商:WILEY‐VCH Verlag    

年代:1968

数据来源: WILEY

摘要:

AbstractNε‐(6‐purinoyl)‐L‐lysine has been prepared by acylation of L‐lysine copper complex or Nα‐carbobenzoxy‐L‐lysine with 6‐trichloromethylpurine followed by the removal of the protecting group. β‐(5‐uracilyl)‐DL‐alanine has been prepared by condensation of 5‐chloro‐methyluracil with diethyl acetamidomalon

ISSN:0021-2148    

DOI:10.1002/ijch.196800081

出版商:WILEY‐VCH Verlag    

年代:1968

数据来源: WILEY