摘要:

Since distomer impurity in the compendia enantiomer may indicate the lack of careful purification or an ability of racemization, the control of enantiomeric purity has growing significance. Although α1- acid - glycoprotein (AGP) stationary phase was applied for the separation of a number of drug enantiomers, it was hardly used for testing of enantiomer purity.

ISSN:1082-6076    

DOI:10.1080/10826079808003597

出版商:Taylor & Francis Group    

年代:1998

数据来源: Taylor

摘要:

A sensitive and rapid high-performance liquid chromato-graphic method using UV detection, has been developed for the analysis of meropenem in plasma. This involved a single liquid-solid extraction on Isolute C18-EC column in the presence of an internal standard (ceftazidime). Analysis was performed by isocratic elution with a mobile phase consisting of 0.01 M acetate buffer pH 4.8 containing 15% (v/v) methanol, with UV detection at 296 nm. The limit of quantitation of the assay was 0.125 mg/L. The method was applied to a pharmacokinetic study in rats receiving 100 mg/kg by IV route with a good accuracy (94–101%) and precision (less than 13%).

ISSN:1082-6076    

DOI:10.1080/10826079808003598

出版商:Taylor & Francis Group    

年代:1998

数据来源: Taylor

ISSN:1082-6076    

DOI:10.1080/10826079808003599

出版商:Taylor & Francis Group    

年代:1998

数据来源: Taylor

ISSN:1082-6076    

DOI:10.1080/10826079808003600

出版商:Taylor & Francis Group    

年代:1998

数据来源: Taylor

ISSN:1082-6076    

DOI:10.1080/10826079808003601

出版商:Taylor & Francis Group    

年代:1998

数据来源: Taylor

ISSN:1082-6076    

DOI:10.1080/10826079808003602

出版商:Taylor & Francis Group    

年代:1998

数据来源: Taylor