摘要:

AbstractNeurologic complications, including both the acute and chronic forms of inflammatory demyelinating polyradku‐loneuropathy (IDP) are becoming more prevalent among patients with the acquired immunodeficiency syndrome (AIDS) and AIDS‐related‐complex (ARC). Although the etiology of the above radicuioneuropathies is not known, an autoimmune process has been postulated. Plasmapheresis has been reported to be of benefit in both the acute and chronic forms of these neuropathies. In this report we describe the use of plasmapberesis in the treatnient of a patient with ARC and the acute relapsing form of IDP. The treatment consisted of an intensive canne of plasmapheresis following his initial presentation and after an acute relapse which occurred several weeks after his initial presentation. Both the initial presentation and relapse involved respiratory compromise necessitatig intubation and mechanical ventilation. In both instances marked clinical improvement was achieved after initiation of plasmapheresis. Thus, plasmapheresis may have a rote in the management of acute relxpsing IDP associated with human immunodeficiency virus infe

ISSN:0733-2459    

DOI:10.1002/jca.2920040402

出版商:John Wiley&Sons, Inc.    

年代:1988

数据来源: WILEY

摘要:

AbstractCentrifugal devices for donor plasmapheresis that collect platelets as a by‐product have recently been introduced. The platelet yield ranges from 1.2 to 2 × 1011per collection, and the collection time exceeds 50 minutes. An attempt to increase yields and to reduce the procedure time was carried out at our center, taking advantage of the Dideco Eccentriplate (Dideco spa. Mirandola, Italy). Within 30 minutes, 510 ml of plasma were collected along with 3.3 × 1011platelets. The shift of donors from whole blood to plasma and platelet donation generated a progressive decrease in red‐cell availability. In order to maintain plasma and platelet production without affecting the erythrocyte production, a technique was developed that allows the collection of 3.68 × 1011platelets, 250 ml of plasma, and 225 ml of packed red blood cells with a hematocrit of 66.5%. The mean procedure time was 31.6 minutes; 2,671 ml of blood were processed at flow rates of 85–100 ml/minute. The cellular cross contamination of the platelet concentrates was 1.76 × 108(leukocytes) and 2.23 × 108(erythrocytes). Although me procedure was carried out in a selected group of donors, the technical experience has strongly modified our procedure for platelet and plasma

ISSN:0733-2459    

DOI:10.1002/jca.2920040403

出版商:John Wiley&Sons, Inc.    

年代:1988

数据来源: WILEY

摘要:

AbstractPopulations exposed to repetitive needle puncture (such as hemodialysis patients, insulin‐dependent diabetics, and parenteral drug abusers) are at increased risk for nasal carriage ofStophylococcus aurais. These groups appear to have increased susceptibility to serious staphylococcal infection as well. We performed a microbiologie survey on a group of patients receiving regular, long‐term therapeutic apheresis for my asthenia gravis (MG), and compared the rate of nasal staphylococcal carriage with that found in control groups of MG patients not receiving apheresis and ambulatory general medical patients without known risk factors for staphylococcal carriage. Medical records were reviewed for episodes of significant staphyiococcal infection occurring since commencement of apheresis. NasalS. auraiscarriage was found in 9/29 (31%) apheresis patients, 8/30 (27%) MG controls, and 8/30 (27%) general medical controls. No significant difference in frequency of apheresis was noted between carriers and noncarriers. A single episode ofS. aureusbacteremia occurred in 95 patient‐years of apheresis therapy. We conclude that therapeutic apberesis for MG does not increase the risk of staphylococcal carriage, and mat serious infection is infre

ISSN:0733-2459    

DOI:10.1002/jca.2920040404

出版商:John Wiley&Sons, Inc.    

年代:1988

数据来源: WILEY

摘要:

AbstractIn an open trial of cryofiltration in rheumatoid arthritis at our institution, 19 patients received 464 treatments; the intensive schedule of ten treatments in 5 weeks was completed in 14 of the 19, and excellent to good clinical response was achieved in ten of these. The combined results demonstrated significant reductions in Ritchie index, morning stiffness, and 50‐foot walk time in the intensive treatment period, as well as significant increases in hand grip strengths. In the maintenance treatment period treatment frequency was individually selected and at less frequent intervals. Changes in clinical parameters were notably less. Although significant correlations were observed between the percent change in clinical parameters and the percent change in biochemical and hematolog‐ical parameters, no consistent pattern was found. The favorable results of this trial and other uncontrolled trials has led to a two‐center double‐blind controlled trial of cryofiltration in rheumatoid arthritis that is now in p

ISSN:0733-2459    

DOI:10.1002/jca.2920040405

出版商:John Wiley&Sons, Inc.    

年代:1988

数据来源: WILEY

摘要:

AbstractOrgan donation is usually limited to solid tissues; paradoxically, organ donors undergoing expiant are often transfused in preparation for or during surgery. This practice increases the requirement for blood and adds immunological and infectious risks for both recipients and donors of grafts. We have investigated the possibility of supporting an expiant with intraoperative blood salvage and, in the case of a cadaver donor, at the end of the operation, salvaging blood for potential use in the graft recipient. This preliminary report describes the technique and the results obtained in two procedures. The volume of red cells with a hematocrit of 55% obtained from the two donors was 2,090 and 1.180 ml, respectively. These components were employed for the transfusion support of the organ recipients.

ISSN:0733-2459    

DOI:10.1002/jca.2920040406

出版商:John Wiley&Sons, Inc.    

年代:1988

数据来源: WILEY

ISSN:0733-2459    

DOI:10.1002/jca.2920040407

出版商:John Wiley&Sons, Inc.    

年代:1988

数据来源: WILEY

ISSN:0733-2459    

DOI:10.1002/jca.2920040408

出版商:John Wiley&Sons, Inc.    

年代:1988

数据来源: WILEY

ISSN:0733-2459    

DOI:10.1002/jca.2920040409

出版商:John Wiley&Sons, Inc.    

年代:1988

数据来源: WILEY

ISSN:0733-2459    

DOI:10.1002/jca.2920040410

出版商:John Wiley&Sons, Inc.    

年代:1988

数据来源: WILEY

摘要:

AbstractA method has been developed using phthalate oils to quality control units of young red cells (neocytes). Neocytes prepared by the NEOCEL system have a mean young red cell enrichment of 90% with only 3.4% less than 80%. Neocytes prepared in a Wood cell processor have an average enrichment of 81 % with 27% less than 75%. Based on a 12 month period, the patients as a group have received an average of 14% fewer transfusions and an 18% decrease in red cells per kg/yr as compared to frozen red cells.

ISSN:0733-2459    

DOI:10.1002/jca.2920040411

出版商:John Wiley&Sons, Inc.    

年代:1988

数据来源: WILEY