摘要:

AbstractTreatment by low density lipoprotein (LDL) apheresis using dextran sulfate columns (DSC) leads to hemostasis alterations with prolonged activated partial thromboplastin time (APTT) of more than 120 seconds. In order to explain this hypocoagulability, we studied hemostasis parameters both in patients and in the extracorporeal circulation (ECC). Hemostasis changes are first related to unfractionated heparin (UFH)—needed to avoid circuit coagulation—which leads to high residual heparinemia in the patient (more than 3 times the recommended level for therapeutic use). Second, the hypocoagulability is induced by a coagulation factor decrease (primarily factors V, VIH, and X) mainly due to an adsorption mechanism on dextran sulfate. Studies on samples from column inflow, outflow, and eluate confirm this mechanism. Low molecular weight heparin (LMWH) can be used in LDL apheresis on DSC without major changes in lipid removal or coagulation factors compared to UFH. The benefit of using LMWH is to reduce residual heparinemia into the therapeutic range. © 1993 Wiley‐Lis

ISSN:0733-2459    

DOI:10.1002/jca.2920080302

出版商:John Wiley&Sons, Inc.    

年代:1993

数据来源: WILEY

摘要:

AbstractThe influence of the continuous‐flow automated blood cell separator, Fenwal CS‐3000, on blood coagulation and the fibrinolytic system in blood donors was studied. Blood samples were taken from the collection line of donors undergoing extracorporeal circulation, before and after platelet pheresis. Of the molecular markers, prothrombin fragment‐Fl + 2 (PFI + 2) markedly increased from 0.8 ± 0.3 to 2.9 ± 2.0 nM/ml (P<.004), thrombin antithrombin III complex (TAT) also markedly increased from 2.6 ± 1.3 to 56.0 ± 24.0 μg/L (P<.001), fibrinopeptide A (FPA) increased slightly from 0.8 ± 0.9 to 3.8 ± 4.2 μg/L (P<.05), and α2‐plasmin inhibitor (α2‐PI) decreased slightly from 95 ± 8 to 91 ± 9% (P<.05). In one donor with the highest level of PFI + 2, TAT, FPA, and plasmin inhibitor complex after platelet pheresis, protein C, protein S, C4b‐binding protein, ATIII, plasminogen, α2‐PI, and coagulation factors were decreased. In blood donors undergoing platelet pheresis using the continuous‐flow automated blood cell separator, Fenwal CS‐3000, a hypercoagulable state was observed. Changing the materials of the plastic disposables to a more thromboresistant material may prevent the hypercoagulable state in donors induced by platelet pheresis using the blood cell sep

ISSN:0733-2459    

DOI:10.1002/jca.2920080303

出版商:John Wiley&Sons, Inc.    

年代:1993

数据来源: WILEY

ISSN:0733-2459    

DOI:10.1002/jca.2920080304

出版商:John Wiley&Sons, Inc.    

年代:1993

数据来源: WILEY

摘要:

AbstractA review of where we are as a society after 10 years into the HIV epidemic: how this information will influence public policy over the next 10 years and what factors will influence policy. © 1993 Wiley‐Liss, I

ISSN:0733-2459    

DOI:10.1002/jca.2920080305

出版商:John Wiley&Sons, Inc.    

年代:1993

数据来源: WILEY

摘要:

AbstractMajor questions have been raised concerning an individual's risk for contracting HIV infection when they come into contact with a patient who has AIDS in the home and/or workplace. Specific concerns are addressed and guidelines are reviewed. © 1993 Wiley‐Liss, I

ISSN:0733-2459    

DOI:10.1002/jca.2920080306

出版商:John Wiley&Sons, Inc.    

年代:1993

数据来源: WILEY

摘要:

AbstractThe status of clinical drug trials is reviewed along with how these experimental protocols have influenced treatment for HIV and AIDS. © 1993 Wiley‐Liss, I

ISSN:0733-2459    

DOI:10.1002/jca.2920080307

出版商:John Wiley&Sons, Inc.    

年代:1993

数据来源: WILEY

摘要:

AbstractWorld geographic patterns of HIV infection are discussed. Various parameters such as age, route of transmission, exposure, culture, and geographical influences are addressed. Future trends for HIV infection and development of AIDS and associated disorders such as non‐Hodgkin's lymphoma are suggested and strategies are suggested to reduce the impact of this epidemic. © 1993 Wiley‐Liss,

ISSN:0733-2459    

DOI:10.1002/jca.2920080308

出版商:John Wiley&Sons, Inc.    

年代:1993

数据来源: WILEY

摘要:

AbstractRemarks are offered on the future of the HIV‐infected individual, the system's ability to care for more HIV‐infected individuals, and our global ability to maintain our efforts to fight this disease. © 1993 Wiley‐Lis

ISSN:0733-2459    

DOI:10.1002/jca.2920080309

出版商:John Wiley&Sons, Inc.    

年代:1993

数据来源: WILEY

ISSN:0733-2459    

DOI:10.1002/jca.2920080310

出版商:John Wiley&Sons, Inc.    

年代:1993

数据来源: WILEY

ISSN:0733-2459    

DOI:10.1002/jca.2920080311

出版商:John Wiley&Sons, Inc.    

年代:1993

数据来源: WILEY