摘要:

Little work has been performed on the serum response of various carotene isomers. The present study was carried out to examine the serum response of all-trans and 9-cis isomers of beta-carotene (BC) using frequent blood sample collections at early time points.Serum responses of all-trans BC and a mixture of BC isomers containing 80% 9-cis BC were studied in 15 men by measuring the serum concentrations of BC at 1, 3, 5, 7, 9, 12, and 24 hours after a single large oral dose of all-trans BC or 9-cis BC.The serum response to an oral dose of all-trans BC (120 mg) significantly increased from baseline at 24 hr (p<0.004). After an oral dose of a mixture of BC isomers (120 mg, 80% 9-cis BC), the peak concentration of 9-cis BC was significantly greater that baseline values (p<0.016).Increases in serum all-trans BC levels, in part, may be due to greater intestinal absorption, whereas the inability to measure a significant increase in the concentration of 9-cis BC may indicate poor absorption, isomerization to all-trans BC, or a very rapid tissue uptake.

ISSN:0731-5724    

DOI:10.1080/07315724.1996.10718639

出版商:Routledge    

年代:1996

数据来源: Taylor

摘要:

To investigate relationships between serum lipid profiles, milk consumption and lifestyle, in a Japanese population.A cross-sectional study in 12,610 Japanese men aged 30 to 69 years. Serum total-cholesterol (TC), HDL-cholesterol (HDLC), LDL-cholesterol (LDLC), TC/HDLC ratio, and triglycerides (TG) were determined. Milk consumption was classified into“Yes”(3553 men) and“No”(9057 men) groups by a self-administered questionnaire“Do you drink a glass of cow's milk (180 to 200 mL) or more everyday?”. Five variables (age, body mass index, habitual exercise, and smoking and drinking habits) were considered confounding factors for the serum lipids.Regardless of age, the“Yes”group had higher levels of serum TC, HDLC and LDLC than the“No”group except for one comparison (HDLC in 50 to 54 year old group). The differences in serum TC (p<0.001), HDLC (p<0.001) and LDLC (p<0.001) between the two groups were significant by ANOVA. However, milk consumption had no significant relations to serum TC/HDLC ratio or TG level. Multivariate models including the five confounding factors confirmed these results, and indicated that the“Yes”group had higher adjusted means of serum TC by 0.079 mmol/L (+1.5%, 5.280 vs. 5.201 mmol/L, p<0.001), HDLC by 0.018 mmol/L (+1.4%, 1.260 vs. 1.242 mmol/L, p<0.01), and LDLC by 0.066 mmol/L (+2.0%, 3.382 vs. 3.316 mmol/L, p<0.001) than the“No”group.Milk consumption is part of a lifestyle related to hypercholesterolemia in the Japanese.

ISSN:0731-5724    

DOI:10.1080/07315724.1996.10718640

出版商:Routledge    

年代:1996

数据来源: Taylor

ISSN:0731-5724    

DOI:10.1080/07315724.1996.10738026

出版商:Routledge    

年代:1996

数据来源: Taylor

ISSN:0731-5724    

DOI:10.1080/07315724.1996.10738027

出版商:Routledge    

年代:1996

数据来源: Taylor

ISSN:0731-5724    

DOI:10.1080/07315724.1996.10718641

出版商:Routledge    

年代:1996

数据来源: Taylor

ISSN:0731-5724    

DOI:10.1080/07315724.1996.10718642

出版商:Routledge    

年代:1996

数据来源: Taylor

ISSN:0731-5724    

DOI:10.1080/07315724.1996.10738028

出版商:Routledge    

年代:1996

数据来源: Taylor

ISSN:0731-5724    

DOI:10.1080/07315724.1996.10738029

出版商:Routledge    

年代:1996

数据来源: Taylor