摘要:

Zinc (Zn) determinations were performed on blood plasma and red cells, liver, heart, adrenals, and spleen of spontaneously hypertensive (SHR) and control normotensive (WKY) male rats, 20 weeks of age. SHR revealed higher red cell (p = 2×10(−5)) and heart (p = 0.007) Zn levels than WKY rats. The water content of organs was the same in the two strains. When compared with published data, these results suggest an association between high cell Zn levels and hypertension, the meaning of which is briefly discussed.

ISSN:0731-5724    

DOI:10.1080/07315724.1990.10720390

出版商:Routledge    

年代:1990

数据来源: Taylor

摘要:

The role of dietary polyunsaturated fats in the prevention of human vascular disease has not been defined, but population and intervention studies have suggested that omega-3 fatty acids (FAs) from marine lipids may have a number of potentially beneficial effects. Eicosanoids are extremely potent autacoids made from polyunsaturated fatty acids and have effects on many vascular parameters, so that the physiological effects of dietary supplementation with polyunsaturated fats are often attributed to alterations in endogenous eicosanoid production. Few studies have attempted to correlate in vivo eicosanoid synthesis and functional effects during such dietary maneuvers, however. This article reviews the relationship between dietary polyunsaturates and endogenous eicosanoid synthesis in man, with particular emphasis on recent studies of the effects of omega-3 FAs. Data on omega-3 FAs and platelet-vascular interactions, blood pressure, and vascular reactivity in human subjects are also summarized, with interpretation of recent work addressing a number of controversial points. A discussion of the significance and future direction of such investigations concludes that further clinical trials in selected patient groups are warranted.

ISSN:0731-5724    

DOI:10.1080/07315724.1990.10720391

出版商:Routledge    

年代:1990

数据来源: Taylor

摘要:

It has previously been shown that fish oil supplementation, compared to olive oil, reduces plasma fibrinogen. Presented here are the results of a randomized, double-blind, crossover controlled trail that compared the effects of dietary n-3 and n-6 fatty acid supplementation on plasma fibrinogen levels in 10 patients with hyperlipoproteinemia types IIb or IV. Plasma fibrinogen levels showed statistically significant reductions during both the fish oil and corn oil treatment periods. Other variables related to hemostasis which showed no significant changes from baseline included tissue plasminogen activator activity and inhibitor, protein C antigen, antithrombin III activity, bleeding time, and platelet counts. These data confirm the two previous reports that fish oil supplementation is associated with reductions in plasma fibrinogen levels, thereby modifying a potential nonlipid risk factor for cardiovascular disease. Unlike previous reports, however, n-6 polyunsaturated fatty acids were also associated with significant reductions in fibrinogen levels. Therefore, it is premature to conclude that the fibrinogen-lowering effects of dietary fish oil are unique to n-3 polyunsaturated fatty acids.

ISSN:0731-5724    

DOI:10.1080/07315724.1990.10720392

出版商:Routledge    

年代:1990

数据来源: Taylor

摘要:

Cord clamping at birth leads to interruption of calcium (Ca) supply to the fetus. After birth, neonatal parathyroid hormone (PTH) secretion appears stimulated by hypocalcemia, with serum PTH increasing after birth and peaking at 24 hours of age. This rise in PTH presumably leads to bone resorption and Ca release. We theorize that bone formation may also be affected and that a serum marker of bone formation, serum osteocalcin (OC) concentrations, will decrease postnatally. OC is synthesized by osteoblasts and its serum concentrations are believed to reflect bone formation. We measured serum ionized Ca (iCa), PTH, and OC in cord blood and at 2 and 24 hours in 26 neonates born after uncomplicated pregnancies, labors, and deliveries. Serum iCa (mg/dl) decreased from 5.79 +/−0.06 (cord, means +/−SEM) to 5.31 +/−0.05 (2 hr), then to 4.89 +/−0.05 (24 hr) (p less than 0.05). Serum PTH (microliter Eq/ml) increased from 35.9 +/−4.3 (cord) to 41.7 +/−4.0 (2 hr) (p = 0.1), and to 50.3 +/−4.6 (24 hr) (p less than 0.01). Serum OC (ng/ml) decreased from 55.1 +/−10.6 (cord), to 12.4 +/−4.3 (2 hr) (p less than 0.01), then remained stable at 12.7 +/−1.9 (24 hr). The change (cord minus 24 hr) in OC correlated inversely with the change in PTH over the first 24 hours of age (r = -0.42. p = 0.03). Therefore, there is a sudden decrease in an index of bone formation (i.e., serum OC) in the first 24 hours of life in which rising serum PTH may have had an impact.(ABSTRACT TRUNCATED AT 250 WORDS)

ISSN:0731-5724    

DOI:10.1080/07315724.1990.10720393

出版商:Routledge    

年代:1990

数据来源: Taylor

ISSN:0731-5724    

DOI:10.1080/07315724.1990.10720394

出版商:Routledge    

年代:1990

数据来源: Taylor

ISSN:0731-5724    

DOI:10.1080/07315724.1990.10738159

出版商:Routledge    

年代:1990

数据来源: Taylor

ISSN:0731-5724    

DOI:10.1080/07315724.1990.10738160

出版商:Routledge    

年代:1990

数据来源: Taylor

ISSN:0731-5724    

DOI:10.1080/07315724.1990.10720395

出版商:Routledge    

年代:1990

数据来源: Taylor

ISSN:0731-5724    

DOI:10.1080/07315724.1990.10738161

出版商:Routledge    

年代:1990

数据来源: Taylor

ISSN:0731-5724    

DOI:10.1080/07315724.1990.10720396

出版商:Routledge    

年代:1990

数据来源: Taylor