摘要:

We evaluated the differential effects of feeding two very-low-calorie diets upon the fractions of plasma and urinary carnitine in obese females. Ten subjects received either diet D1, a 420 kcal/day formula diet, or diet D2, a 500-600 kcal/day meat/fish/poultry diet. Plasma and urinary carnitine levels were determined at the start of the study. After 1 month, plasma carnitine levels were obtained; at 2 months, both plasma and urinary carnitine levels were obtained. Subjects receiving diet D2 showed significantly higher levels of plasma total carnitine over the course of the study (p less than 0.05). Plasma short-chain acylcarnitine esters increased and free carnitine declined significantly in both groups during the study period. Subjects receiving D1 excreted significantly less urinary carnitine than those receiving D2. We conclude that long-term ingestion of very-low-calorie diets causes alterations in plasma carnitine metabolism.

ISSN:0731-5724    

DOI:10.1080/07315724.1990.10720378

出版商:Routledge    

年代:1990

数据来源: Taylor

摘要:

An animal study was conducted to examine the effects of alcohol consumption on placental transfer of zinc during late gestation. Throughout pregnancy, rat dams were fed a nutritionally adequate diet with 30% of total kcal as alcohol. On days 18 and 21 of pregnancy, zinc-65 was injected subcutaneously into the dams and the dams were killed 24 hours later; tissues were removed for analyses. Maternal serum, liver, kidney, and heart zinc decreased with gestational age while total fetal zinc increased. Neither the decrease in maternal organ zinc nor fetal accretion were affected by alcohol consumption. Placental zinc concentration also declined with developmental age and was not influenced by alcohol consumption. The decrease in placental zinc was accompanied by a decrease in zinc associated with 4-10-kD proteins of placental cytosol. Our results suggest that zinc flux during late rat gestation is a well-regulated process that is not influenced by alcohol consumption. Coordination of the transfer apparently is influenced by maternal blood concentration of zinc, placental zinc-binding proteins, and fetal demand for zinc.

ISSN:0731-5724    

DOI:10.1080/07315724.1990.10720379

出版商:Routledge    

年代:1990

数据来源: Taylor

ISSN:0731-5724    

DOI:10.1080/07315724.1990.10720380

出版商:Routledge    

年代:1990

数据来源: Taylor