ISSN:0731-5724    

DOI:10.1080/07315724.1989.10738130

出版商:Routledge    

年代:1989

数据来源: Taylor

摘要:

Canola oil is a newly marketed vegetable oil for use in salads and for cooking that contains 55% of the monounsaturated fatty acid; oleic acid, 25% linoleic acid and 10% alpha-linolenate [polyunsaturated fatty acid (PUFA)], and only 4% of the saturated fatty acids (SFAs) that have been implicated as factors in hypercholesterolemia. It is expressed from a cultivar of rapeseed that was selectively bred from old varieties in Canada to be very low in erucic acid–a fatty acid suspected to have pathogenic potential in diets high in the original rapeseed oil in experimental animals. Canola oil is free of those problems. It is the most widely consumed food oil in Canada, and has been approved for Generally Recognized as Safe (GRAS) status by the Food and Drug Administration (FDA) of the United States Department of Health and Human Services. The fatty acid composition of canola oil is consistent with its use as a substitute for SFAs, in meeting the dietary goals recommended by many health associations: an average diet containing about 30% of calories as fat made up of less than 10% SFAs, 8-10% PUFAs in a ratio of linoleic to linolenic acids between 4:1 and 10:1, the remainder being monounsaturated fatty acids. No single oil meets these current recommendations for ratios of PUFA/monounsaturated/polyunsaturated fatty acid ratios as the sole source of cooking and salad oil.

ISSN:0731-5724    

DOI:10.1080/07315724.1989.10720311

出版商:Routledge    

年代:1989

数据来源: Taylor

摘要:

The potentially beneficial blood pressure (BP)-lowering effects of marine omega-3 polyunsaturated fatty acids (omega-3-PUFAs) remain controversial. The objective of this qualitative and quantitative (meta-analysis) analysis was to evaluate the results of all available randomized controlled trials that studied the effect of omega-3-PUFAs on BP response. A comprehensive search of the English literature from 1970 to 1988 disclosed only six randomized controlled investigations out of 22 published reports. Four of these were evaluable and therefore eligible for this analysis. Of these, only one evaluated hypertensive subjects. In two trials, there were statistically significant reductions in BP; the one reporting an investigation of hypertensive subjects showed the greatest reduction. Using established methodologic criteria, the quality of each report was evaluated by independent observers. Following this appraisal, the outcomes of each investigation were reanalyzed and pooled using a meta-analysis. There was no statistically significant difference between the omega-3-PUFA groups and the control groups, possibly because of failure to include hypertensive subjects in all but one trial. Despite the positive effects in two studies, little scientifically valid evidence is available to demonstrate a significant BP-lowering effect of omega-3-PUFAs. Areas needing more attention in future research are identified and methods to improve study designs are suggested.

ISSN:0731-5724    

DOI:10.1080/07315724.1989.10720312

出版商:Routledge    

年代:1989

数据来源: Taylor

摘要:

This experiment was conducted to determine the relationships between modest changes in dietary linoleate, blood pressure (BP) response, and levels of eicosanoid synthesis in humans. Products of eicosanoids which appear in blood were measured in urine: PGI2, 6-keto-PGF1 alpha (KPGI2); TXA2, (TXB2); PGF2 alpha, 13,14-dihydro-15-keto-PGF2 alpha, (MPGF2 alpha). Twenty-three adult men were fed controlled diets having 25 energy percent fat, and having P/S ratios of either 0.3 (low-PUFA) or 1.0 (high-PUFA), for a total of 12 weeks, with a switchover between P/S ratios at 6 weeks. The results showed that, under the conditions of this study, BP was significantly reduced by reducing dietary fat intake from about 37 to 25 energy percent. However, no further effects on BP were produced by increasing the P/S ratio from 0.3 to 1.0. KPGI2 excretion was significantly lowered on both controlled diets as compared to the self-selected (SS) diet. However, MPGF2 alpha was lowered only on the low-PUFA diet as compared to the self-selected diet. No significant decrease in TXB2 excretion was observed. Both MPGF2 alpha and KPGI2 excretion were positively correlated with urine volume and sodium excretion. On the SS diet, but not on the controlled diets, MPGF2 alpha excretion was negatively correlated with plasma linoleate and positively correlated with stearate. On the low-PUFA diet, MPGF2 alpha excretion increased with the intake of linoleate, while, on the high-PUFA diet, it decreased. This may have been due to the limited amounts of linoleate available in the low-PUFA diet (3.2-3.4 energy percent) as compared to that in the high-PUFA diet. Both KPGI2 and MPGF2 alpha excretion were positively correlated with systolic and diastolic BP. These results suggest that the amount of dietary linoleate is an important factor in the regulation of prostaglandin synthesis in humans.

ISSN:0731-5724    

DOI:10.1080/07315724.1989.10720313

出版商:Routledge    

年代:1989

数据来源: Taylor

摘要:

Associations among serum lipids (total cholesterol, LDL-cholesterol, HDL-cholesterol, and triglycerides) and levels of serum zinc (S-Zn), serum copper (S-Cu), and their ratio were analyzed in 3373 3-, 6-, 9-, 12-, 15-, and 18-year-old Finnish girls and boys. S-Zn was positively related to total cholesterol, HDL-cholesterol, and LDL-cholesterol; S-Cu related negatively to HDL-cholesterol. Obesity did not affect these relationships. The few exceptionally high lipid levels found were not associated with very low or high S-Zn or S-Cu. S-Zn and S-Cu were related to serum lipids; causality between the variables, however, remains to be studied.

ISSN:0731-5724    

DOI:10.1080/07315724.1989.10720314

出版商:Routledge    

年代:1989

数据来源: Taylor

摘要:

The increase in cardiac disease [fatal and nonfatal myocardial infarction (MI), and sudden death] in the post-war years in Norway, after the much lower incidence during the war, that coincided with high and low fat intakes, respectively, led to a trial in Oslo to determine whether lowering dietary fat intake would favorably influence occurrence of coronary heart disease (CHD). Dietary modification, which lowered serum cholesterol of men who had suffered a first-time MI, showed decreased reinfarction incidence and cardiac deaths as compared with a comparable group of controls. Another study of normotensive high-risk men (on the basis of serum cholesterol and smoking habits) showed that dietetic measures can be useful in preventing CHD.

ISSN:0731-5724    

DOI:10.1080/07315724.1989.10720315

出版商:Routledge    

年代:1989

数据来源: Taylor