摘要:

To see whether relative differences in the glycemic responses to different foods were similar in insulin-dependent (IDDM) and non-insulin-dependent diabetic patients (NIDDM) we determined the glycemic index (GI) of a total of 20 foods and mixed test meals in groups of IDDM and NIDDM volunteers. The mean GI values ranged from 32 in NIDDM and 41 in IDDM (pearled barley) to 105 in NIDDM and 111 in IDDM (bread with cheese and tomato). The correlation between the mean GI values in IDDM and NIDDM was highly significant (r = 0.927, p less than 0.001). The mean GI values for 15 of the 20 test meals was greater in IDDM than in NIDDM (mean of GI for all 20 foods, 76 in IDDM compared with 68 in NIDDM, p less than 0.005). However, the difference in GI between IDDM and NIDDM was t statistically significant for 19 of the 20 individual test meals. Greater within-individual variability of glycemic responses in IDDM probably accounts for the slightly greater mean GI value seen in IDDM compared with NIDDM. The addition of 32 g cheddar cheese to four foods which were also fed without cheese had no significant effect on the GI in NIDDM (mean GI of 68 without cheese compared with 72 for the meals with cheese), but had a small effect in IDDM where the mean GI was increased from 72 to 87 (p less than 0.05). However, despite small increases in glycemic response to foods with added cheese, the relative differences between foods were unaffected by the addition of cheese in both IDDM and NIDDM. It is concluded that mean GI values for foods are very similar in IDDM and NIDDM patients.

ISSN:0731-5724    

DOI:10.1080/07315724.1987.10720191

出版商:Routledge    

年代:1987

数据来源: Taylor

摘要:

Plasma vitamin E levels and age have been positively correlated up to the sixth decade of life. Since antioxidants protect biomembranes in vivo against oxidative damage, it has been hypothesized that free radical scavengers such as vitamin E may have protective effects against aging. In the present study, plasma vitamin E and lipids were determined in 95 healthy volunteers [mean age (+/−S.D.) 55.9 +/−24.5 yr]. Special attention was focused on vitamin E status in the elderly: 23 individuals were older than 80 years. A significant age effect (p less than 0.005) was observed for both vitamin E and cholesterol, both being increased in the middle-aged group (40-59 yr) and decreased in the elderly (greater than or equal to 80 yr). Since a high plasma cholesterol represents a major risk factor for ischemic heart disease, decreasing levels of plasma cholesterol with advancing age in a healthy population-sample appears to be the result of negative selection. Plasma vitamin E concentration was correlated (p less than 0.001) with total cholesterol, triglyceride, and total lipid. Since vitamin E is mainly transported by plasma lipoproteins, these strong correlations suggest that changes in vitamin E should be considered as an epiphenomenon of altered plasma transport capacity. The determination of plasma vitamin E is therefore a poor indicator of the real tissue vitamin E activity.

ISSN:0731-5724    

DOI:10.1080/07315724.1987.10720192

出版商:Routledge    

年代:1987

数据来源: Taylor

摘要:

Essential hypertension (EHT) is one of the most common risk factors for cerebrovascular and cardiovascular disease (CVD), which in turn are among the most common causes of death and disability in developed countries. Drug treatment of EHT has proven effective in lessening the risk of CVD, but has attendant risk of side effects, some of which are of risk to the CV system. Thus, increasing attention is being paid to non-drug treatment of EHT, which includes changing the daily intake of such electrolytes as sodium (Na), potassium (K), calcium (Ca), and magnesium (Mg). Decreasing Na intake to control blood pressure (BP) is well established. On the basis of epidemiologic and experimental studies, increasing K and/or Mg intakes, and increasing of decreasing Ca intakes, have each been proposed to have beneficial effects of BP. Presented here is a review of the background data supporting the rationale for adding Mg to the anti-hypertensive regimen. There is evidence that Mg can exert a favorable effect in EHT, particularly when used in combination with K during diuretic therapy.

ISSN:0731-5724    

DOI:10.1080/07315724.1987.10720194

出版商:Routledge    

年代:1987

数据来源: Taylor

摘要:

Magnesium balance, and plasma and urinary levels, were studied in spontaneously hypertensive (SHR), Wistar Kyoto (WKY) and in Wistar (WI) rats. We found few differences in the measured parameters between WKY and WI rats, but the SHR rat which similarly maintained Mg balance has lower plasma Mg levels and less urinary Mg excretion. These abnormalities could favor establishment or maintenance of hypertension.

ISSN:0731-5724    

DOI:10.1080/07315724.1987.10720195

出版商:Routledge    

年代:1987

数据来源: Taylor

摘要:

Six normal volunteers consumed high protein, high carbohydrate, and high fat isocaloric diets on a metabolic ward for 10 days each. On the high protein diet, serum creatinine, BUN, albumin, and total protein exceeded the normal range in from one to four subjects; the increases were directly related to the percentage of calories derived from protein (R = 0.82, 0.62, and 0.73 respectively; all p less than 0.01). Fasting serum glucose was higher on the high protein diet than on the high fat diet (p less than 0.01); values on the high carbohydrate diet were intermediate. Fasting serum glucose was not significantly related to the percentage of either total carbohydrates or simple carbohydrates in the diet. Within the range of diets frequently ingested in the United States, laboratory values can vary significantly and can exceed the normal ranges in healthy individuals. These variations may mislead clinicians and lead to further unnecessary tests.

ISSN:0731-5724    

DOI:10.1080/07315724.1987.10720196

出版商:Routledge    

年代:1987

数据来源: Taylor

摘要:

Zinc deficiency in children with chronic renal failure may be due to inadequate intake or excessive losses. To determine the effect of dialysate solute type and concentration on the net absorption or loss of zinc from the peritoneal cavity, six CAPD patients ages 9-19 years were dialyzed with 1.3% and 2.3% amino acid-containing dialysis solutions and 2.5% and 4.25% glucose-containing solutions on four separate occasions. Zinc contamination of the initial effluent dialysis solutions was quite high (17.1 +/−7.7 micrograms/dl) but did not differ between the four solutions. Significantly higher zinc retention was documented with the glucose-containing dialysis solutions compared to the amino acid-containing solutions (99.8 +/−32.7 vs. 28.3 +/−51.3 micrograms, 2.5% G vs 1.3% AA, p less than 0.01; 146.0 +/−112.6 vs. 23.0 +/−84.3, 4.25% G vs 2.3% AA, p less than .01). Although the mechanism is unclear, results of this study confirm in children that there is significant net absorption of zinc from glucose containing dialysis solutions at both high and low glucose concentrations. Thus, CAPD does not contribute to zinc depletion. Solute concentration did not affect net zinc absorption; thus it appears that movement of zinc across the peritoneum is dependent on solute type (amino acid or glucose) and independent of the osmolality.

ISSN:0731-5724    

DOI:10.1080/07315724.1987.10720197

出版商:Routledge    

年代:1987

数据来源: Taylor

摘要:

A homosexual youth presented with undiagnosed acute cryptosporidial cholecystitis, a fever of 102.8 degrees F and a WBC of 3500/mm3. This was preceded by several months of watery diarrhea and 20% weight loss. Following cholecystectomy, G-I function was maintained by efficient esophageal aspiration of swallowed air, with simultaneous immediate duodenal feeding of elemental diet. He absorbed 160 g amino acids and 4200 kcal, and was safely self-sufficient when discharged 26 hours postoperatively. Reappearance of the persistent cryptosporidial enteritis was followed by diagnoses of the offending organism and the associated AIDS. He failed to respond to specific spiramycin therapy, and 8 months after cholecystectomy he succumbed to pneumocystis carinii pneumonia. For this malnourished and particularly vulnerable patient, preservation of postoperative G-I function and its exploitation for enteral support may have been essential to enhance“immune competence”and lead to a remarkably smooth and rapid recovery.

ISSN:0731-5724    

DOI:10.1080/07315724.1987.10720198

出版商:Routledge    

年代:1987

数据来源: Taylor

摘要:

Isolated hearts from rats subjected to high and low dietary Mg for 4 weeks were perfused with buffers containing 0.8 and 0.3 mM Mg, these values reflecting the plasma Mg concentrations on the two intakes. After a 20 min period of subtotal, global ischemia the recovery values of cardiac function were significantly lower in hearts from Mg-depleted rats perfused with 0.3 mM Mg, whereas the control values of cardiac function of the two groups were nearly identical before the ischemic episode. An additional group of hearts from Mg depleted rats perfused with 0.8 mM Mg did not present higher values of post-ischemic cardiac function compared to those perfused with 0.3 mM Mg. Rats fed a low dietary Mg had lower concentrations of Mg in plasma, bone and skeletal muscle, but not in the heart. The only myocardial electrolyte difference was a higher Na in the low dietary Mg group. It is concluded that an acquired extracellular Mg deficiency may reduce the myocardial tolerance to ischemia. The rapid restoration to high extracellular Mg in a prolonged Mg deficiency state did not improve the myocardial tolerance to an immediate ischemic episode.

ISSN:0731-5724    

DOI:10.1080/07315724.1987.10720199

出版商:Routledge    

年代:1987

数据来源: Taylor

ISSN:0731-5724    

DOI:10.1080/07315724.1987.10720200

出版商:Routledge    

年代:1987

数据来源: Taylor

ISSN:0731-5724    

DOI:10.1080/07315724.1987.10737927

出版商:Routledge    

年代:1987

数据来源: Taylor