摘要:

AbstractA general method for combining information from similar experiments is illustrated in the case where two independent experiments are designed to estimate a dose‐response curve. By accounting for variability across experiments, the proposed method avoids inferential pitfalls such as extended forms of Simpson's paradox. The validity of the method is supported by seven fundamental assumptions about data from replicated experiments. In contrast, an example indicates that failing to reject a preliminary test of equal distributions is inadequate justification for pooling data from two experiments. Methods that account for the variability across experiments in terms of known covariates are also discusse

ISSN:0323-3847    

DOI:10.1002/bimj.4710300402

出版商:WILEY‐VCH Verlag    

年代:1988

数据来源: WILEY

摘要:

AbstractSuppose that independent experiments each indicate general qualitative results, such as higher than normal incidence rates of tumors for exposed populations. This paper suggests methods for amalgamating the qualitative results from several such experiments into a more quantitative form, such as a dose‐response relationship. The methods are designed to be robust both to systematic bias in one of the experiments and also to procedural variability across experiments. Data from four rodent experiments with tolazamide are used to illustrate the method

ISSN:0323-3847    

DOI:10.1002/bimj.4710300403

出版商:WILEY‐VCH Verlag    

年代:1988

数据来源: WILEY

摘要:

AbstractThe problem of estimatingM, the number of classes in a population, is formulated as an occupancy problem in whichNitems are drawn fromMurns. Under the assumption of a uniform distribution for the number of classes in the population, the sufficient statistic forM, which is the number of distinct classes observed, does not depend upon the number of repetitions in the sample. Point and interval estimates ofMare developed using maximum likelihood and the method of moments. Both techniques give rise to the same basic equation which requires a simple iterative solution. These same techniques are used in the more general situation in which the classes can be further subdivided according to type.

ISSN:0323-3847    

DOI:10.1002/bimj.4710300404

出版商:WILEY‐VCH Verlag    

年代:1988

数据来源: WILEY

摘要:

AbstractArobusttwo‐sample Studentt‐type procedure based on symmetrically censored samples proposed by Tiku (1980, 1982a, b) is studied from the Bayesian point of view. The effect of asymmetric censoring on this procedure is investigated and a good approximation to its posterior distribution in this case is worked out. An illustrative example is also presen

ISSN:0323-3847    

DOI:10.1002/bimj.4710300405

出版商:WILEY‐VCH Verlag    

年代:1988

数据来源: WILEY

ISSN:0323-3847    

DOI:10.1002/bimj.4710300406

出版商:WILEY‐VCH Verlag    

年代:1988

数据来源: WILEY

摘要:

AbstractIn multiple assays a ‘Standard’ preparation is compared in a single assay with two or more ‘Test’ preparations (Finney, 1978, ch. 11). In addition to the estimation of the relative potency of the ‘Test’ preparations the question arises as to simultaneous confidence limits, or else a joint confidence region for these relative potencies. This paper compares a joint confidence region using a LR statistic with separate limits based on Fieller's theorem.These results are presented in an Example on a multiple assay of two tuberculin preparations A, B compared with a Standard one (data of Wadley, Finney, 1978,

ISSN:0323-3847    

DOI:10.1002/bimj.4710300407

出版商:WILEY‐VCH Verlag    

年代:1988

数据来源: WILEY

ISSN:0323-3847    

DOI:10.1002/bimj.4710300408

出版商:WILEY‐VCH Verlag    

年代:1988

数据来源: WILEY

摘要:

AbstractIn many practical situations the experiment is conducted using a block design, and it is desired to estimate a given set of contrasts with variances none of which is greater than a corresponding set of specified variances: In the present paper the form of the intra‐block matrix of a design is, therefore, derived for such situations. Usefulness of the results given is illustrated with the help of examples. The construction of two‐plot block designs is shown to be particularly straightforw

ISSN:0323-3847    

DOI:10.1002/bimj.4710300409

出版商:WILEY‐VCH Verlag    

年代:1988

数据来源: WILEY

摘要:

AbstractThe positive ascertainment of location differences in a multivariate comparison of two or more groups gives rise to the question for the contribution of the single variables or of subsets of variables to the multivariate difference. In this paper two methods are proposed to accomplish the original multivariate test by tests in variable subsets or in single variables using a closed test procedure and Holm's procedure, respectively. Both control the multiple level of the whole procedure.

ISSN:0323-3847    

DOI:10.1002/bimj.4710300410

出版商:WILEY‐VCH Verlag    

年代:1988

数据来源: WILEY

摘要:

AbstractThe paper deals with discrete‐time regression models to analyze multistate‐multiepisode failure time data. The covariate process may include fixed and external as well as internal time dependent covariates. The effects of the covariates may differ among different kinds of failures and among successive episodes. A dynamic form of the logistic regression model is investigated and maximum likelihood estimation of the regression coefficients is discussed. In the last section we give an application of the model to the analysis of survival time after breast cancer operat

ISSN:0323-3847    

DOI:10.1002/bimj.4710300411

出版商:WILEY‐VCH Verlag    

年代:1988

数据来源: WILEY